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A9AXH8 (A9AXH8_HERA2) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3 HAMAP MF_01815
EC=2.3.1.180 HAMAP MF_01815
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III HAMAP MF_01815
Beta-ketoacyl-ACP synthase III HAMAP MF_01815
Gene names
Name:fabH HAMAP MF_01815
Ordered Locus Names:Haur_0744
OrganismHerpetosiphon aurantiacus (strain ATCC 23779 / DSM 785) [Complete proteome] [HAMAP]
Taxonomic identifier316274 [NCBI]
Taxonomic lineageBacteria › Chloroflexi › Herpetosiphonales › Herpetosiphonaceae › Herpetosiphon

Protein attributes

Sequence length328 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity. HAMAP MF_01815

Catalytic activity

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2. HAMAP MF_01815

Pathway

Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01815 SAAS SAAS013747

Subunit structure

Homodimer By similarity. HAMAP MF_01815 SAAS SAAS013747

Subcellular location

Cytoplasm By similarity HAMAP MF_01815 SAAS SAAS013747.

Domain

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH By similarity. HAMAP MF_01815

Sequence similarities

Belongs to the FabH family. HAMAP MF_01815

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region253 – 2575ACP-binding By similarity HAMAP MF_01815

Sites

Active site1121 By similarity HAMAP MF_01815
Active site2521 By similarity HAMAP MF_01815
Active site2821 By similarity HAMAP MF_01815

Sequences

Sequence LengthMass (Da)Tools
A9AXH8 [UniParc].

Last modified January 15, 2008. Version 1.
Checksum: 2B09FD08D0B1DC37

FASTA32834,970
        10         20         30         40         50         60 
MNAAITGWGR YAPDRVLTNQ ELEQIVDTND EWIQSRTGIQ RRHIVAEGQA TSDMSARAAR 

        70         80         90        100        110        120 
IALDKAGVKP EELDLIVVAT TSPDLLLPST AALVQTKLGA INAGVMDMNA ACCGFLYALS 

       130        140        150        160        170        180 
AVTAMIRGGG VGKVLLCGAE TISPFLNWQD RNTCVIFGDA AGAVILEATE QERGLQSYKL 

       190        200        210        220        230        240 
GAIPDTAELL WIKAGATLYP ATHERLDQSE QYIQMNGSEV FKHAVRSMVD SSLHVLNQVG 

       250        260        270        280        290        300 
KTPADVQLVV PHQANLRIIE AVAKRLNVSM DQVFVNIQEY GNTSAATLPV AIAEAADAGR 

       310        320 
MQPGDTILLT AFGGGLTWAS GVLVWGGK

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References

[1]"Complete sequence of chromosome of Herpetosiphon aurantiacus ATCC 23779."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Kim E., Bryant D.A., Richardson P.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 23779 / DSM 785.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000875 Genomic DNA. Translation: ABX03392.1.
RefSeqYP_001543520.1. NC_009972.1.

3D structure databases

ProteinModelPortalA9AXH8.
ModBaseSearch...

Protein-protein interaction databases

STRINGA9AXH8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5732467.
GenomeReviewsGene locus Haur_0744 in contig CP000875_GR.
KEGGhau:Haur_0744.
PATRIC22118433. VBIHerAur93466_0762.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG649927.
OMAKEIGAIN.

Family and domain databases

HAMAPMF_01815. FabH.
[Tree]
InterProIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
KOK00648.
PfamPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMSSF53901. Thiolase-like. 1 hit.
TIGRFAMsTIGR00747. FabH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA9AXH8_HERA2
AccessionPrimary (citable) accession number: A9AXH8
Entry history
Integrated into UniProtKB/TrEMBL: January 15, 2008
Last sequence update: January 15, 2008
Last modified: December 14, 2011
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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