Reviewed, UniProtKB/Swiss-Prot A9AW17 (HUTI_HERA2)

Names and origin

Protein names

Recommended name:
    Imidazolonepropionase
    EC=3.5.2.7
Alternative name(s):
    Imidazolone-5-propionate hydrolase

Gene names

Name:	hutI
Ordered Locus Names:	Haur_0607

Organism

Herpetosiphon aurantiacus (strain ATCC 23779 / DSM 785) [Complete proteome] [HAMAP]

Taxonomic identifier

316274 [NCBI]

Taxonomic lineage

Bacteria › Chloroflexi › Herpetosiphonales › Herpetosiphonaceae › Herpetosiphon

Protein attributes

Sequence length	427 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	(S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate + H2O = N-formimidoyl-L-glutamate + H+. HAMAP MF_00372
Cofactor	Binds 1 zinc or iron ion per subunit By similarity.
Pathway	Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 3/3. HAMAP MF_00372
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the hutI family.

Ontologies

Keywords
Biological process	Histidine metabolism
Cellular component	Cytoplasm
Ligand	Iron Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine catabolic process to glutamate and formamide Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	imidazolonepropionase activity Inferred from electronic annotation. Source: HAMAP iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 427	427	Imidazolonepropionase HAMAP MF_00372		PRO_1000121544
Sites
	Metal binding	78	1	Zinc or iron By similarity
	Metal binding	80	1	Zinc or iron By similarity
	Metal binding	255	1	Zinc or iron By similarity
	Metal binding	330	1	Zinc or iron By similarity
	Binding site	87	1	Substrate By similarity
	Binding site	100	1	Substrate By similarity
	Binding site	150	1	Substrate By similarity
	Binding site	183	1	Substrate By similarity
	Binding site	258	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	A9AW17-1 [UniParc]. Last modified January 15, 2008. Version 1. Checksum: 27B954844CEBAE2E	FASTA	427	45,338
	10 20 30 40 50 60 MPHADQLITN IGRLVTGPQA PLRGQQLAQL TAIDQAVVAV QAGNIVALGS QAELSAWTAD 70 80 90 100 110 120 QTIDAGGYLA IPGFVDPHTH ACYAGDRAHE FELRIKGASY SELMAAGGGI MSTVHATRAA 130 140 150 160 170 180 SKAELVAQTR PRLDQLLAHG TTTVEIKSGY GLDTATELTM LEAIAELAQT HPIGIVPTFM 190 200 210 220 230 240 GAHAIPAEYR DNPEAFVDLV VDEMLPAVAA WWQQQTIWQE PLACDIFCEN GAFSVAQSQR 250 260 270 280 290 300 ILVKAKALGF RLKLHVDEFE PLGGTPLAVE LGAISVDHLV ATPPEHIAIL ANSETVGVSL 310 320 330 340 350 360 PGTPFGLGKS QFSPARSLIE ANGILALATD CNPGTSPCES MPMAIAIACR YLRLTPAEAL 370 380 390 400 410 420 NAATVNSAFA IRQHERVGSL AVGMQADLAL LNLPDERHIG YKFGTNPVAI VIKTGRVVRR NQLHADR

References

[1]

"Complete sequence of chromosome of Herpetosiphon aurantiacus ATCC 23779." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Kim E., Bryant D.A., Richardson P. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000875 Genomic DNA. Translation: ABX03255.1.
RefSeq	YP_001543383.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5732505.
GenomeReviews	Gene locus Haur_0607 in contig CP000875_GR.
KEGG	hau:Haur_0607.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	MNMACTL.
Family and domain databases
HAMAP	MF_00372. [Tree]
InterPro	IPR006680. Amidohydro_1. IPR005920. HutI. [Graphical view]
Pfam	PF01979. Amidohydro_1. 2 hits. [Graphical view]
ProDom	PD001248. Amidohydro_like. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01224. hutI. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HUTI_HERA2

Accession

Primary (citable) accession number: A9AW17

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	January 15, 2008
Last modified:	November 3, 2009
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)