A9ANA1 (GCH4_BURM1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GTP cyclohydrolase folE2
EC=3.5.4.16

Gene names

Name:	folE2
Ordered Locus Names:	Bmul_4819, BMULJ_03697

Organism

Burkholderia multivorans (strain ATCC 17616 / 249) [Complete proteome] [HAMAP]

Taxonomic identifier

395019 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex › Burkholderia multivorans

Protein attributes

Sequence length	269 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Converts GTP to 7,8-dihydroneopterin triphosphate By similarity. HAMAP-Rule MF_01527
Catalytic activity	GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_01527
Pathway	Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_01527
Sequence similarities	Belongs to the GTP cyclohydrolase IV family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	7,8-dihydroneopterin 3'-triphosphate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	GTP cyclohydrolase I activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 269	269	GTP cyclohydrolase folE2 HAMAP-Rule MF_01527		PRO_0000372024
Sites
	Site	154	1	May be catalytically important By similarity

Sequences

	Sequence		Length	Mass (Da)
	A9ANA1 [UniParc]. Last modified January 15, 2008. Version 1. Checksum: B98650930DFE6AF9	FASTA	269	30,105
	10 20 30 40 50 60 MNQMNPAFVM PDVQSTVDTR QIPIQRVGVK AVRHPLTVLT ESGDVQPTVG VWNLDVRLPA 70 80 90 100 110 120 EQKGTHMSRF VALLEENRAP LTIERFRAMI ASMLEKLEAE AGRIEVTFPY FVNKTAPVSG 130 140 150 160 170 180 VQSLLDYEVT LAGESRNGDT RLFLKVLVPV TSLCPCSKKI SQYGAHNQRS HVTIDAELAA 190 200 210 220 230 240 DVPVEALIRI AEEEASCELW GLLKRPDEKF VTERAYENPK FVEDLVRDVA ARLDADARIV 250 260 AYVLEAENFE SIHNHSAYAL IERDKRHAA

References

[1]

"Complete sequence of chromosome 2 of Burkholderia multivorans ATCC 17616." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Tiedje J., Richardson P. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 17616 / 249.

[2]

"Complete genome sequence of Burkholderia multivorans ATCC 17616." Ohtsubo Y., Yamashita A., Kurokawa K., Takami H., Yuhara S., Nishiyama E., Endo R., Miyazaki R., Ono A., Yano K., Ito M., Sota M., Yuji N., Hattori M., Tsuda M. Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 17616 / 249.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000869 Genomic DNA. Translation: ABX18490.1. AP009386 Genomic DNA. Translation: BAG45569.1.
RefSeq	YP_001584782.1. NC_010086.1. YP_001948105.1. NC_010805.1.
3D structure databases
ProteinModelPortal	A9ANA1.
SMR	A9ANA1. Positions 21-265.
ModBase	Search...
Protein-protein interaction databases
STRING	395019.Bmul_4819.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABX18490; ABX18490; Bmul_4819. BAG45569; BAG45569; BMULJ_03697.
GeneID	5768810. 6362073.
KEGG	bmj:BMULJ_03697. bmu:Bmul_4819.
PATRIC	19169454. VBIBurMul203716_4764.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1469.
HOGENOM	HOG000280679.
KO	K09007.
OMA	INMYVDL.
ProtClustDB	PRK13674.
Enzyme and pathway databases
BioCyc	BMUL395019:GIYO-3695-MONOMER.
UniPathway	UPA00848; UER00151.
Family and domain databases
Gene3D	3.10.270.10. 1 hit.
HAMAP	MF_01527_B. GTP_cyclohydrol_B.
InterPro	IPR022838. GTP_cyclohydrolase_FolE2. IPR003801. GTP_cyclohydrolase_FolE2/MptA. IPR002042. Uricase. [Graphical view]
Pfam	PF02649. GCHY-1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCH4_BURM1

Accession

Primary (citable) accession number: A9ANA1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 5, 2009
Last sequence update:	January 15, 2008
Last modified:	May 1, 2013
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program