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A9ANA1

- GCH4_BURM1

UniProt

A9ANA1 - GCH4_BURM1

Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Burkholderia multivorans (strain ATCC 17616 / 249)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei154 – 1541May be catalytically importantUniRule annotation

    GO - Molecular functioni

    1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciBMUL395019:GIYO-3695-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
    Gene namesi
    Name:folE2UniRule annotation
    Ordered Locus Names:Bmul_4819, BMULJ_03697
    OrganismiBurkholderia multivorans (strain ATCC 17616 / 249)
    Taxonomic identifieri395019 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
    ProteomesiUP000007064: Chromosome 2, UP000008815: Chromosome 2

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 269269GTP cyclohydrolase FolE2PRO_0000372024Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi395019.Bmul_4819.

    Structurei

    3D structure databases

    ProteinModelPortaliA9ANA1.
    SMRiA9ANA1. Positions 21-265.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase IV family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1469.
    HOGENOMiHOG000280679.
    KOiK09007.
    OMAiDVQSSRD.
    OrthoDBiEOG6X6RBH.

    Family and domain databases

    HAMAPiMF_01527_B. GTP_cyclohydrol_B.
    InterProiIPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view]
    PfamiPF02649. GCHY-1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A9ANA1-1 [UniParc]FASTAAdd to Basket

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    MNQMNPAFVM PDVQSTVDTR QIPIQRVGVK AVRHPLTVLT ESGDVQPTVG    50
    VWNLDVRLPA EQKGTHMSRF VALLEENRAP LTIERFRAMI ASMLEKLEAE 100
    AGRIEVTFPY FVNKTAPVSG VQSLLDYEVT LAGESRNGDT RLFLKVLVPV 150
    TSLCPCSKKI SQYGAHNQRS HVTIDAELAA DVPVEALIRI AEEEASCELW 200
    GLLKRPDEKF VTERAYENPK FVEDLVRDVA ARLDADARIV AYVLEAENFE 250
    SIHNHSAYAL IERDKRHAA 269
    Length:269
    Mass (Da):30,105
    Last modified:January 15, 2008 - v1
    Checksum:iB98650930DFE6AF9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000869 Genomic DNA. Translation: ABX18490.1.
    AP009386 Genomic DNA. Translation: BAG45569.1.
    RefSeqiYP_001584782.1. NC_010086.1.
    YP_001948105.1. NC_010805.1.

    Genome annotation databases

    EnsemblBacteriaiABX18490; ABX18490; Bmul_4819.
    BAG45569; BAG45569; BMULJ_03697.
    GeneIDi5768810.
    6362073.
    KEGGibmj:BMULJ_03697.
    bmu:Bmul_4819.
    PATRICi19169454. VBIBurMul203716_4764.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000869 Genomic DNA. Translation: ABX18490.1 .
    AP009386 Genomic DNA. Translation: BAG45569.1 .
    RefSeqi YP_001584782.1. NC_010086.1.
    YP_001948105.1. NC_010805.1.

    3D structure databases

    ProteinModelPortali A9ANA1.
    SMRi A9ANA1. Positions 21-265.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 395019.Bmul_4819.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABX18490 ; ABX18490 ; Bmul_4819 .
    BAG45569 ; BAG45569 ; BMULJ_03697 .
    GeneIDi 5768810.
    6362073.
    KEGGi bmj:BMULJ_03697.
    bmu:Bmul_4819.
    PATRICi 19169454. VBIBurMul203716_4764.

    Phylogenomic databases

    eggNOGi COG1469.
    HOGENOMi HOG000280679.
    KOi K09007.
    OMAi DVQSSRD.
    OrthoDBi EOG6X6RBH.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci BMUL395019:GIYO-3695-MONOMER.

    Family and domain databases

    HAMAPi MF_01527_B. GTP_cyclohydrol_B.
    InterProi IPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view ]
    Pfami PF02649. GCHY-1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome 2 of Burkholderia multivorans ATCC 17616."
      Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Tiedje J., Richardson P.
      Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 17616 / 249.
    2. "Complete genome sequence of Burkholderia multivorans ATCC 17616."
      Ohtsubo Y., Yamashita A., Kurokawa K., Takami H., Yuhara S., Nishiyama E., Endo R., Miyazaki R., Ono A., Yano K., Ito M., Sota M., Yuji N., Hattori M., Tsuda M.
      Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 17616 / 249.

    Entry informationi

    Entry nameiGCH4_BURM1
    AccessioniPrimary (citable) accession number: A9ANA1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 5, 2009
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3