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A9AN09 (A9AN09_BURM1) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Serine hydroxymethyltransferase 2 HAMAP MF_00051
Short name=SHMT 2 HAMAP MF_00051
Short name=Serine methylase 2 HAMAP MF_00051
EC=2.1.2.1 HAMAP MF_00051
Gene names
Name:glyA EMBL BAG46817.1
Synonyms:glyA2 HAMAP MF_00051
Ordered Locus Names:Bmul_3546, BMULJ_04971
OrganismBurkholderia multivorans (strain ATCC 17616 / 249) [Complete proteome] [HAMAP]
Taxonomic identifier395019 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length424 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Interconversion of serine and glycine By similarity. RuleBase RU000585 HAMAP MF_00051

Catalytic activity

5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. RuleBase RU000585 HAMAP MF_00051

Cofactor

Pyridoxal phosphate By similarity. RuleBase RU000585 HAMAP MF_00051

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_00051

One-carbon metabolism; tetrahydrofolate pathway. RuleBase RU000585

Subunit structure

Homotetramer By similarity. HAMAP MF_00051

Subcellular location

Cytoplasm By similarity HAMAP MF_00051.

Sequence similarities

Belongs to the SHMT family. RuleBase RU004104 HAMAP MF_00051

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Amino acid modifications

Modified residue2341N6-(pyridoxal phosphate)lysine By similarity HAMAP MF_00051

Sequences

Sequence LengthMass (Da)Tools
A9AN09 [UniParc].

Last modified January 15, 2008. Version 1.
Checksum: 1CB3C6D7532578DB

FASTA42445,541
        10         20         30         40         50         60 
MSNTQSFFSQ PLAERDAPVR SAILKELERQ QSQVELIASE NIVSRAVLEA QGSVLTNKYA 

        70         80         90        100        110        120 
EGYPGKRYYG GCEFADEVEA LAIDRVKKIF NAGYANVQPH SGAQANGSVM LALAKPGDTV 

       130        140        150        160        170        180 
LGMSLDAGGH LTHGAKPALS GKWFNAVQYG VNRDTMRIDY DQVEELAQQH KPSLIIAGFS 

       190        200        210        220        230        240 
AYPRALDFAR FRAIADSVGA KLMVDMAHIA GVIAAGRHAN PVEHAHVVTS TTHKTLRGPR 

       250        260        270        280        290        300 
GGFVLTNDEE IAKKINSAVF PGLQGGPLMH VIAGKAVAFG EVLQPDFKTY IDNVLANAQA 

       310        320        330        340        350        360 
LGEVLKAGGV DLVTGGTDNH LLLVDLRPKG LKGAQVEQAL ERAGITCNKN GIPFDTEKPT 

       370        380        390        400        410        420 
ITSGIRLGTP AGTTRGFGVA EFREIGRLIL EVFDALRANP EGDAATEQRV RREIFALCER 


FPIY

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References

[1]"Complete genome sequence of Burkholderia multivorans ATCC 17616."
Ohtsubo Y., Yamashita A., Kurokawa K., Takami H., Yuhara S., Nishiyama E., Endo R., Miyazaki R., Ono A., Yano K., Ito M., Sota M., Yuji N., Hattori M., Tsuda M.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 17616 EMBL BAG46817.1 and ATCC 17616 / 249.
[2]"Complete sequence of chromosome 2 of Burkholderia multivorans ATCC 17616."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Tiedje J., Richardson P.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 17616 / 249.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000869 Genomic DNA. Translation: ABX17230.1.
AP009386 Genomic DNA. Translation: BAG46817.1.
RefSeqYP_001583522.1. NC_010086.1.
YP_001949353.1. NC_010805.1.

3D structure databases

ProteinModelPortalA9AN09.
SMRA9AN09. Positions 12-389.
ModBaseSearch...

Protein-protein interaction databases

STRINGA9AN09.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5770078.
6362071.
GenomeReviewsGene locus BMULJ_04971 in contig AP009386_GR.
Gene locus Bmul_3546 in contig CP000869_GR.
KEGGbmj:BMULJ_04971.
bmu:Bmul_3546.
PATRIC19172081. VBIBurMul203716_6076.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG301263.
OMAIFNAGYA.
ProtClustDBPRK13034.

Family and domain databases

HAMAPMF_00051. SHMT.
[Tree]
InterProIPR015424. PyrdxlP-dep_Trfase_major_dom.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR001085. Ser_HO-MeTrfase.
IPR019798. Ser_HO-MeTrfase_PLP_BS.
[Graphical view]
Gene3DG3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
KOK00600.
PANTHERPTHR11680. Gly_HO-Metrfase. 1 hit.
PfamPF00464. SHMT. 1 hit.
[Graphical view]
PIRSFPIRSF000412. SHMT. 1 hit.
SUPFAMSSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
PROSITEPS00096. SHMT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA9AN09_BURM1
AccessionPrimary (citable) accession number: A9AN09
Entry history
Integrated into UniProtKB/TrEMBL: January 15, 2008
Last sequence update: January 15, 2008
Last modified: January 25, 2012
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info