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Protein

Oxygen-dependent choline dehydrogenase

Gene

betA

Organism
Burkholderia multivorans (strain ATCC 17616 / 249)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.UniRule annotation

Catalytic activityi

Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: betaine biosynthesis via choline pathway

This protein is involved in step 1 of the subpathway that synthesizes betaine aldehyde from choline (cytochrome c reductase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Oxygen-dependent choline dehydrogenase (betA)
This subpathway is part of the pathway betaine biosynthesis via choline pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes betaine aldehyde from choline (cytochrome c reductase route), the pathway betaine biosynthesis via choline pathway and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei474Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi7 – 36FADUniRule annotationAdd BLAST30

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein, NAD

Enzyme and pathway databases

UniPathwayiUPA00529; UER00385

Protein family/group databases

CAZyiAA3 Auxiliary Activities 3

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent choline dehydrogenaseUniRule annotation (EC:1.1.99.1UniRule annotation)
Short name:
CDHUniRule annotation
Short name:
CHDUniRule annotation
Alternative name(s):
Betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
Short name:
BADHUniRule annotation
Gene namesi
Name:betAUniRule annotation
Ordered Locus Names:Bmul_3536, BMULJ_04981
OrganismiBurkholderia multivorans (strain ATCC 17616 / 249)
Taxonomic identifieri395019 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
Proteomesi
  • UP000008815 Componenti: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001333231 – 566Oxygen-dependent choline dehydrogenaseAdd BLAST566

Proteomic databases

PRIDEiA9AMZ9

Interactioni

Protein-protein interaction databases

STRINGi395019.BMULJ_04981

Structurei

3D structure databases

ProteinModelPortaliA9AMZ9
SMRiA9AMZ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GMC oxidoreductase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CZ6 Bacteria
COG2303 LUCA
HOGENOMiHOG000139600
KOiK00108
OMAiGWDYAHC
OrthoDBiPOG091H04UT

Family and domain databases

Gene3Di3.50.50.60, 4 hits
4.10.450.10, 2 hits
HAMAPiMF_00750 Choline_dehydrogen, 1 hit
InterProiView protein in InterPro
IPR011533 BetA
IPR036188 FAD/NAD-bd_sf
IPR027424 Glucose_Oxidase_domain_2
IPR012132 GMC_OxRdtase
IPR000172 GMC_OxRdtase_N
IPR007867 GMC_OxRtase_C
PANTHERiPTHR11552:SF157 PTHR11552:SF157, 1 hit
PfamiView protein in Pfam
PF05199 GMC_oxred_C, 1 hit
PF00732 GMC_oxred_N, 1 hit
PIRSFiPIRSF000137 Alcohol_oxidase, 1 hit
SUPFAMiSSF51905 SSF51905, 2 hits
TIGRFAMsiTIGR01810 betA, 1 hit
PROSITEiView protein in PROSITE
PS00623 GMC_OXRED_1, 1 hit
PS00624 GMC_OXRED_2, 1 hit

Sequencei

Sequence statusi: Complete.

A9AMZ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTREYDYII CGAGSAGNVL ATRLTEDPNV TVLLLEAGGP DYRFDFRTQM
60 70 80 90 100
PAALAYPLQG RRYNWAYETD PEPHMDNRRM ECGRGKGLGG SSLINGMCYI
110 120 130 140 150
RGNALDYDNW ATHQGLENWT YLDCLPYFKK AETRDIGPND YHGGDGPVSV
160 170 180 190 200
TTSKPGVNPL FEAMVEAGVQ AGYPRTEDLN GYQQEGFGPM DRTVTPKGRR
210 220 230 240 250
ASTARGYLDQ AKTRPNLEIV THALADRILF DGKRASGVTY LRGNERATAH
260 270 280 290 300
ARREVLVCSG AIASPQLLQR SGVGPGAWLK ELDIPIVLDL PGVGQNLQDH
310 320 330 340 350
LEMYIQYECK EPVSLYPALK WWNQPKIGLE WMLNGTGLGA SNHFEAGGFI
360 370 380 390 400
RTRDDDPWPN IQYHFLPVAI NYNGSNAIEM HGFQAHVGSM RSPSRGRVKL
410 420 430 440 450
RSRDPNAHPS ILFNYMAEAL DWREFRDAIR ATREIMRQPA LDRYRGRELN
460 470 480 490 500
PGADLKSDKE LDAFVRARAE TAFHPSCSCK MGYDDMAVVD NEGRVHGLEG
510 520 530 540 550
LRVVDASIMP IITTGNLNAP TIMIAEKIAD KIRGRKPLER ANVPYFVANG
560
APARNVAKAV RQPETV
Length:566
Mass (Da):62,958
Last modified:January 15, 2008 - v1
Checksum:i1D3CFF0E9E050550
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000869 Genomic DNA Translation: ABX17220.1
AP009386 Genomic DNA Translation: BAG46827.1
RefSeqiWP_006406015.1, NC_010805.1

Genome annotation databases

EnsemblBacteriaiABX17220; ABX17220; Bmul_3536
BAG46827; BAG46827; BMULJ_04981
KEGGibmj:BMULJ_04981
bmu:Bmul_3536

Similar proteinsi

Entry informationi

Entry nameiBETA_BURM1
AccessioniPrimary (citable) accession number: A9AMZ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: January 15, 2008
Last modified: May 23, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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