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A9AMZ9

- BETA_BURM1

UniProt

A9AMZ9 - BETA_BURM1

Protein

Oxygen-dependent choline dehydrogenase

Gene

betA

Organism
Burkholderia multivorans (strain ATCC 17616 / 249)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.UniRule annotation

    Catalytic activityi

    Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
    Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

    Cofactori

    FAD.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei474 – 4741UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi7 – 3630FADUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
    2. choline dehydrogenase activity Source: UniProtKB-HAMAP
    3. flavin adenine dinucleotide binding Source: InterPro

    GO - Biological processi

    1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein, NAD

    Enzyme and pathway databases

    BioCyciBMUL395019:GIYO-4978-MONOMER.
    UniPathwayiUPA00529; UER00385.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Oxygen-dependent choline dehydrogenaseUniRule annotation (EC:1.1.99.1UniRule annotation)
    Short name:
    CDHUniRule annotation
    Short name:
    CHDUniRule annotation
    Alternative name(s):
    Betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
    Short name:
    BADHUniRule annotation
    Gene namesi
    Name:betAUniRule annotation
    Ordered Locus Names:Bmul_3536, BMULJ_04981
    OrganismiBurkholderia multivorans (strain ATCC 17616 / 249)
    Taxonomic identifieri395019 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
    ProteomesiUP000007064: Chromosome 2, UP000008815: Chromosome 2

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 566566Oxygen-dependent choline dehydrogenasePRO_1000133323Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi395019.Bmul_3536.

    Structurei

    3D structure databases

    ProteinModelPortaliA9AMZ9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GMC oxidoreductase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2303.
    HOGENOMiHOG000139600.
    KOiK00108.
    OMAiYLQYACT.
    OrthoDBiEOG67HJQP.

    Family and domain databases

    HAMAPiMF_00750. Choline_dehydrogen.
    InterProiIPR011533. BetA.
    IPR012132. GMC_OxRdtase.
    IPR000172. GMC_OxRdtase_N.
    IPR007867. GMC_OxRtase_C.
    [Graphical view]
    PfamiPF05199. GMC_oxred_C. 1 hit.
    PF00732. GMC_oxred_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
    TIGRFAMsiTIGR01810. betA. 1 hit.
    PROSITEiPS00623. GMC_OXRED_1. 1 hit.
    PS00624. GMC_OXRED_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A9AMZ9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTREYDYII CGAGSAGNVL ATRLTEDPNV TVLLLEAGGP DYRFDFRTQM    50
    PAALAYPLQG RRYNWAYETD PEPHMDNRRM ECGRGKGLGG SSLINGMCYI 100
    RGNALDYDNW ATHQGLENWT YLDCLPYFKK AETRDIGPND YHGGDGPVSV 150
    TTSKPGVNPL FEAMVEAGVQ AGYPRTEDLN GYQQEGFGPM DRTVTPKGRR 200
    ASTARGYLDQ AKTRPNLEIV THALADRILF DGKRASGVTY LRGNERATAH 250
    ARREVLVCSG AIASPQLLQR SGVGPGAWLK ELDIPIVLDL PGVGQNLQDH 300
    LEMYIQYECK EPVSLYPALK WWNQPKIGLE WMLNGTGLGA SNHFEAGGFI 350
    RTRDDDPWPN IQYHFLPVAI NYNGSNAIEM HGFQAHVGSM RSPSRGRVKL 400
    RSRDPNAHPS ILFNYMAEAL DWREFRDAIR ATREIMRQPA LDRYRGRELN 450
    PGADLKSDKE LDAFVRARAE TAFHPSCSCK MGYDDMAVVD NEGRVHGLEG 500
    LRVVDASIMP IITTGNLNAP TIMIAEKIAD KIRGRKPLER ANVPYFVANG 550
    APARNVAKAV RQPETV 566
    Length:566
    Mass (Da):62,958
    Last modified:January 15, 2008 - v1
    Checksum:i1D3CFF0E9E050550
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000869 Genomic DNA. Translation: ABX17220.1.
    AP009386 Genomic DNA. Translation: BAG46827.1.
    RefSeqiYP_001583512.1. NC_010086.1.
    YP_001949363.1. NC_010805.1.

    Genome annotation databases

    EnsemblBacteriaiABX17220; ABX17220; Bmul_3536.
    BAG46827; BAG46827; BMULJ_04981.
    GeneIDi5769978.
    6361992.
    KEGGibmj:BMULJ_04981.
    bmu:Bmul_3536.
    PATRICi19172105. VBIBurMul203716_6088.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000869 Genomic DNA. Translation: ABX17220.1 .
    AP009386 Genomic DNA. Translation: BAG46827.1 .
    RefSeqi YP_001583512.1. NC_010086.1.
    YP_001949363.1. NC_010805.1.

    3D structure databases

    ProteinModelPortali A9AMZ9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 395019.Bmul_3536.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABX17220 ; ABX17220 ; Bmul_3536 .
    BAG46827 ; BAG46827 ; BMULJ_04981 .
    GeneIDi 5769978.
    6361992.
    KEGGi bmj:BMULJ_04981.
    bmu:Bmul_3536.
    PATRICi 19172105. VBIBurMul203716_6088.

    Phylogenomic databases

    eggNOGi COG2303.
    HOGENOMi HOG000139600.
    KOi K00108.
    OMAi YLQYACT.
    OrthoDBi EOG67HJQP.

    Enzyme and pathway databases

    UniPathwayi UPA00529 ; UER00385 .
    BioCyci BMUL395019:GIYO-4978-MONOMER.

    Family and domain databases

    HAMAPi MF_00750. Choline_dehydrogen.
    InterProi IPR011533. BetA.
    IPR012132. GMC_OxRdtase.
    IPR000172. GMC_OxRdtase_N.
    IPR007867. GMC_OxRtase_C.
    [Graphical view ]
    Pfami PF05199. GMC_oxred_C. 1 hit.
    PF00732. GMC_oxred_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
    TIGRFAMsi TIGR01810. betA. 1 hit.
    PROSITEi PS00623. GMC_OXRED_1. 1 hit.
    PS00624. GMC_OXRED_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome 2 of Burkholderia multivorans ATCC 17616."
      Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Tiedje J., Richardson P.
      Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 17616 / 249.
    2. "Complete genome sequence of Burkholderia multivorans ATCC 17616."
      Ohtsubo Y., Yamashita A., Kurokawa K., Takami H., Yuhara S., Nishiyama E., Endo R., Miyazaki R., Ono A., Yano K., Ito M., Sota M., Yuji N., Hattori M., Tsuda M.
      Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 17616 / 249.

    Entry informationi

    Entry nameiBETA_BURM1
    AccessioniPrimary (citable) accession number: A9AMZ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3