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Protein

Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene

lpxA

Organism
Burkholderia multivorans (strain ATCC 17616 / 249)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

(R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + UDP-N-acetyl-alpha-D-glucosamine = [acyl-carrier-protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetyl-alpha-D-glucosamine.UniRule annotation

Pathwayi: lipid IV(A) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine.UniRule annotation
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase (lpxA)
  2. UDP-3-O-acyl-N-acetylglucosamine deacetylase (lpxC)
  3. no protein annotated in this organism
  4. UDP-2,3-diacylglucosamine hydrolase (lpxH)
  5. Lipid-A-disaccharide synthase (lpxB)
  6. Tetraacyldisaccharide 4'-kinase (lpxK)
This subpathway is part of the pathway lipid IV(A) biosynthesis, which is itself part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine, the pathway lipid IV(A) biosynthesis and in Glycolipid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processLipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00359; UER00477

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferaseUniRule annotation (EC:2.3.1.129UniRule annotation)
Short name:
UDP-N-acetylglucosamine acyltransferaseUniRule annotation
Gene namesi
Name:lpxAUniRule annotation
Ordered Locus Names:Bmul_1269, BMULJ_01978
OrganismiBurkholderia multivorans (strain ATCC 17616 / 249)
Taxonomic identifieri395019 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
Proteomesi
  • UP000008815 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001226901 – 262Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferaseAdd BLAST262

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi395019.BMULJ_01978

Structurei

3D structure databases

ProteinModelPortaliA9AIM6
SMRiA9AIM6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the transferase hexapeptide repeat family. LpxA subfamily.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4105DAF Bacteria
COG1043 LUCA
HOGENOMiHOG000294326
KOiK00677
OMAiRECVTIN
OrthoDBiPOG091H022E

Family and domain databases

CDDicd03351 LbH_UDP-GlcNAc_AT, 1 hit
Gene3Di1.20.1180.10, 1 hit
HAMAPiMF_00387 LpxA, 1 hit
InterProiView protein in InterPro
IPR029098 Acetyltransf_C
IPR037157 Acetyltransf_C_sf
IPR001451 Hexapep
IPR018357 Hexapep_transf_CS
IPR010137 Lipid_A_LpxA
IPR011004 Trimer_LpxA-like_sf
PANTHERiPTHR43480 PTHR43480, 1 hit
PfamiView protein in Pfam
PF13720 Acetyltransf_11, 1 hit
PF00132 Hexapep, 2 hits
PIRSFiPIRSF000456 UDP-GlcNAc_acltr, 1 hit
SUPFAMiSSF51161 SSF51161, 1 hit
TIGRFAMsiTIGR01852 lipid_A_lpxA, 1 hit
PROSITEiView protein in PROSITE
PS00101 HEXAPEP_TRANSFERASES, 1 hit

Sequencei

Sequence statusi: Complete.

A9AIM6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRIHPTAIV EPGAQIDESV EIGPYAIIGP HVTIGARTTI GSHSVIEGHT
60 70 80 90 100
TIGEDNRIGH YASVGGRPQD MKYKDEPTKL VIGNRNTIRE FTTIHTGTVQ
110 120 130 140 150
DAGVTTLGDD NWIMAYVHIG HDCRVGNHVI LSSNAQMAGH VEIGDWAIIG
160 170 180 190 200
GMSGVHQFVR IGAHAMLGGA SALVQDVPPF VIAAGNKAEP HGINVEGLRR
210 220 230 240 250
RGFSPDAISA LRSAYRLLYK NGLSLEEAKT QLRELAQAGG DGDAPVNALV
260
AFIDASQRGI IR
Length:262
Mass (Da):27,873
Last modified:January 15, 2008 - v1
Checksum:iC90BBC7EC37994F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000868 Genomic DNA Translation: ABX14957.1
AP009385 Genomic DNA Translation: BAG43895.1
RefSeqiWP_006402658.1, NC_010804.1

Genome annotation databases

EnsemblBacteriaiABX14957; ABX14957; Bmul_1269
BAG43895; BAG43895; BMULJ_01978
KEGGibmj:BMULJ_01978
bmu:Bmul_1269

Similar proteinsi

Entry informationi

Entry nameiLPXA_BURM1
AccessioniPrimary (citable) accession number: A9AIM6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: January 15, 2008
Last modified: May 23, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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