A9AIL0 (A9AIL0_BURM1) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Peptide deformylase 1 HAMAP MF_00163
Short name=PDF 1 HAMAP MF_00163
EC=3.5.1.88 HAMAP MF_00163

Alternative name(s):
Polypeptide deformylase 1 HAMAP MF_00163

Gene names

Name:	def EMBL BAG43911.1
Synonyms:	def1 HAMAP MF_00163
Ordered Locus Names:	Bmul_1253, BMULJ_01994

Organism

Burkholderia multivorans (strain ATCC 17616 / 249) [Complete proteome] [HAMAP]

Taxonomic identifier

395019 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length	177 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions By similarity. HAMAP MF_00163
Catalytic activity	Formyl-L-methionyl peptide + H2O = formate + methionyl peptide. SAAS SAAS000181 HAMAP MF_00163
Cofactor	Binds 1 Fe2+ ion By similarity. HAMAP MF_00163
Sequence similarities	Belongs to the polypeptide deformylase family. RuleBase RU003335 HAMAP MF_00163

Ontologies

Keywords
Biological process	Protein biosynthesis SAAS SAAS000181 HAMAP MF_00163
Ligand	Iron HAMAP MF_00163 Metal-binding SAAS SAAS000181 HAMAP MF_00163
Molecular function	Hydrolase SAAS SAAS000181 HAMAP MF_00163 EMBL ABX14941.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	translation Inferred from electronic annotation. Source: HAMAP
Molecular function	iron ion binding Inferred from electronic annotation. Source: InterPro peptide deformylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	142	1	By similarity HAMAP MF_00163
	Metal binding	99	1	Iron By similarity HAMAP MF_00163
	Metal binding	141	1	Iron By similarity HAMAP MF_00163
	Metal binding	145	1	Iron By similarity HAMAP MF_00163

Sequences

	Sequence		Length	Mass (Da)
	A9AIL0 [UniParc]. Last modified January 15, 2008. Version 1. Checksum: A820CEB5923DD649	FASTA	177	19,861
	10 20 30 40 50 60 MIREILKMGD PRLLEVARPV DRFDTPELHE IVADMFETMH HANGAGLAAP QIGIGLQIII 70 80 90 100 110 120 FGFGSNDRYP DAPPVPETVL INPKLEYMPP DMEEGWEGCL SVPGMRGVVS RYAKVRYSGF 130 140 150 160 170 DQFGAKIDRV AEGFHARVVQ HEYDHLIGKL YPMRITDFTR FGFTEVLFPG LDPAADD

References

[1]

"Complete genome sequence of Burkholderia multivorans ATCC 17616." Ohtsubo Y., Yamashita A., Kurokawa K., Takami H., Yuhara S., Nishiyama E., Endo R., Miyazaki R., Ono A., Yano K., Ito M., Sota M., Yuji N., Hattori M., Tsuda M. Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 17616 EMBL BAG43911.1 and ATCC 17616 / 249.

[2]

"Complete sequence of chromosome 1 of Burkholderia multivorans ATCC 17616." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Tiedje J., Richardson P. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 17616 / 249.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000868 Genomic DNA. Translation: ABX14941.1. AP009385 Genomic DNA. Translation: BAG43911.1.
RefSeq	YP_001579438.1. NC_010084.1. YP_001946447.1. NC_010804.1.
3D structure databases
ProteinModelPortal	A9AIL0.
ModBase	Search...
Protein-protein interaction databases
STRING	A9AIL0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5766881. 6360064.
GenomeReviews	Gene locus BMULJ_01994 in contig AP009385_GR. Gene locus Bmul_1253 in contig CP000868_GR.
KEGG	bmj:BMULJ_01994. bmu:Bmul_1253.
PATRIC	19165823. VBIBurMul203716_2984.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG665227.
OMA	IRYEGFD.
ProtClustDB	PRK12846.
Family and domain databases
HAMAP	MF_00163. Pep_deformylase. [Tree]
InterPro	IPR000181. Fmet_deformylase. IPR023635. Peptide_deformylase. [Graphical view]
Gene3D	G3DSA:3.90.45.10. Fmet_deformylase. 1 hit.
KO	K01462.
PANTHER	PTHR10458. Fmet_deformylase. 1 hit.
Pfam	PF01327. Pep_deformylase. 1 hit. [Graphical view]
PIRSF	PIRSF004749. Pep_def. 1 hit.
PRINTS	PR01576. PDEFORMYLASE.
SUPFAM	SSF56420. Fmet_deformylase. 1 hit.
TIGRFAMs	TIGR00079. Pept_deformyl. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A9AIL0_BURM1

Accession

Primary (citable) accession number: A9AIL0

Entry history

Integrated into UniProtKB/TrEMBL:	January 15, 2008
Last sequence update:	January 15, 2008
Last modified:	January 25, 2012
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)