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Protein

Catalase-peroxidase

Gene

katG

Organism
Burkholderia multivorans (strain ATCC 17616 / 249)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei88Transition state stabilizerUniRule annotation1
Active sitei92Proton acceptorUniRule annotation1
Metal bindingi259Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:Bmul_2660, BMULJ_00578
OrganismiBurkholderia multivorans (strain ATCC 17616 / 249)
Taxonomic identifieri395019 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
Proteomesi
  • UP000008815 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003547451 – 728Catalase-peroxidaseAdd BLAST728

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki91 ↔ 218Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-244)UniRule annotation
Cross-linki218 ↔ 244Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-91)UniRule annotation

Post-translational modificationi

Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi395019.BMULJ_00578

Structurei

3D structure databases

SMRiA9AGE5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X Bacteria
COG0376 LUCA
HOGENOMiHOG000218110
KOiK03782
OMAiPEEDIYW
OrthoDBiPOG091H05R1

Family and domain databases

HAMAPiMF_01961 Catal_peroxid, 1 hit
InterProiView protein in InterPro
IPR000763 Catalase_peroxidase
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR019794 Peroxidases_AS
IPR019793 Peroxidases_heam-ligand_BS
PANTHERiPTHR30555 PTHR30555, 1 hit
PfamiView protein in Pfam
PF00141 peroxidase, 2 hits
PRINTSiPR00460 BPEROXIDASE
PR00458 PEROXIDASE
SUPFAMiSSF48113 SSF48113, 2 hits
TIGRFAMsiTIGR00198 cat_per_HPI, 1 hit
PROSITEiView protein in PROSITE
PS00435 PEROXIDASE_1, 1 hit
PS00436 PEROXIDASE_2, 1 hit
PS50873 PEROXIDASE_4, 1 hit

Sequencei

Sequence statusi: Complete.

A9AGE5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTEPKCPFH HTAGSGTSNK DWWPNQINLN ILHRHSSLSD PMDKDFNYAE
60 70 80 90 100
AFKQLDLAAV KRDLHALMTT SQDWWPADFG HYGGLFIRMA WHSAGTYRIA
110 120 130 140 150
DGRGGAGGGQ QRFAPLNSWP DNANLDKARR LLWPIKQKYG RNISWADLLI
160 170 180 190 200
LTGNVALESM GFKTFGYAGG RPDTWEPDDV YWGSEKIWLE LSGGPNSRYS
210 220 230 240 250
GNRELENPLA AVQMGLIYVN PEGPDGNPDP VAAARDIRET FARMAMNDEE
260 270 280 290 300
TVALIAGGHT FGKTHGAGPA SSVGPEPEAA ALEQQGLGWQ STFGTGKGKD
310 320 330 340 350
AITSGLEVTW TSTPTKWSND FFKHLFSYEW ELTKSPAGAH QWVAKDAEAV
360 370 380 390 400
IPDAFDPSKK HRPTMLTTDL ALRFDPEYEK ISRRFYEHPD QFADAFARAW
410 420 430 440 450
FKLTHRDMGP RSRYLGPDVP AEELLWQDPV PAVDHPLIDE ADIAALKAKV
460 470 480 490 500
LASGLSVSQL VSTAWASAST FRGSDKRGGA NGARIRLAPQ KDWEVNRPAE
510 520 530 540 550
LAAVLETLEG VRKAFNDAQT GGKRVSLADL IVLAGAAGVE QAAKNAGVAV
560 570 580 590 600
TVPFAPGRTD ASQEQTDVHA MAVLEPVADG FRNYLKRKFK TPAEALLVDK
610 620 630 640 650
AQLLTLTAPE MTVLVGGMRV LGTNVGDPKH GVFTERPGTL TNDFFVNLLD
660 670 680 690 700
MRTEWKPASA DNDVFEGRDR ATGELKWTGT RVDLVFGSHS QLRALAEVYG
710 720
SADAQQKFVH DFVAAWNKVM NLDRFDLV
Length:728
Mass (Da):79,942
Last modified:November 25, 2008 - v2
Checksum:i8E1446EC9B268E5B
GO

Sequence cautioni

The sequence ABX16344 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000868 Genomic DNA Translation: ABX16344.1 Different initiation.
AP009385 Genomic DNA Translation: BAG42542.1
RefSeqiWP_012467484.1, NC_010804.1

Genome annotation databases

EnsemblBacteriaiABX16344; ABX16344; Bmul_2660
BAG42542; BAG42542; BMULJ_00578
KEGGibmj:BMULJ_00578
bmu:Bmul_2660

Similar proteinsi

Entry informationi

Entry nameiKATG_BURM1
AccessioniPrimary (citable) accession number: A9AGE5
Secondary accession number(s): B3CXN0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: November 25, 2008
Last modified: May 23, 2018
This is version 68 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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