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Protein

Homogentisate 1,2-dioxygenase

Gene

hmgA

Organism
Burkholderia multivorans (strain ATCC 17616 / 249)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.UniRule annotation

Catalytic activityi

Homogentisate + O2 = 4-maleylacetoacetate.UniRule annotation

Cofactori

Fe cationUniRule annotation

Pathwayi: L-phenylalanine degradation

This protein is involved in step 4 of the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine.UniRule annotation
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. Homogentisate 1,2-dioxygenase (hmgA)
  5. no protein annotated in this organism
  6. no protein annotated in this organism
This subpathway is part of the pathway L-phenylalanine degradation, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine, the pathway L-phenylalanine degradation and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei298Proton acceptorUniRule annotation1
Metal bindingi341IronUniRule annotation1
Metal bindingi347IronUniRule annotation1
Binding sitei356homogentisateUniRule annotation1
Metal bindingi377IronUniRule annotation1
Binding sitei377homogentisateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDioxygenase, Oxidoreductase
Biological processPhenylalanine catabolism, Tyrosine catabolism
LigandIron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00139; UER00339

Names & Taxonomyi

Protein namesi
Recommended name:
Homogentisate 1,2-dioxygenaseUniRule annotation (EC:1.13.11.5UniRule annotation)
Short name:
HGDOUniRule annotation
Alternative name(s):
Homogentisate oxygenaseUniRule annotation
Homogentisic acid oxidaseUniRule annotation
HomogentisicaseUniRule annotation
Gene namesi
Name:hmgAUniRule annotation
Ordered Locus Names:Bmul_2563, BMULJ_00675
OrganismiBurkholderia multivorans (strain ATCC 17616 / 249)
Taxonomic identifieri395019 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
Proteomesi
  • UP000008815 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001198431 – 444Homogentisate 1,2-dioxygenaseAdd BLAST444

Interactioni

Subunit structurei

Hexamer; dimer of trimers.UniRule annotation

Protein-protein interaction databases

STRINGi395019.BMULJ_00675

Structurei

3D structure databases

ProteinModelPortaliA9AFM6
SMRiA9AFM6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the homogentisate dioxygenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F1J Bacteria
COG3508 LUCA
HOGENOMiHOG000139824
KOiK00451
OMAiHGNYTPY
OrthoDBiPOG091H04E0

Family and domain databases

Gene3Di2.60.120.10, 1 hit
HAMAPiMF_00334 Homogentis_dioxygen, 1 hit
InterProiView protein in InterPro
IPR005708 Homogentis_dOase
IPR022950 Homogentis_dOase_bac
IPR014710 RmlC-like_jellyroll
IPR011051 RmlC_Cupin_sf
PANTHERiPTHR11056 PTHR11056, 1 hit
PfamiView protein in Pfam
PF04209 HgmA, 1 hit
SUPFAMiSSF51182 SSF51182, 1 hit
TIGRFAMsiTIGR01015 hmgA, 1 hit

Sequencei

Sequence statusi: Complete.

A9AFM6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLDLSKPAT AGYLSGFANE FATEALPGAL PHGRNSPQRA PYGLYAEQLS
60 70 80 90 100
GTAFTAPRGH NRRSWLYRIR PAAVHRPFEP FAGAQRLVSD FADSADVPPT
110 120 130 140 150
PPNQLRWNPL PMPSEPTDFV EGLVTMAGNG SAAAMSGCAI HLYAANRSMR
160 170 180 190 200
DRFFYSADGE LLIVPQQGRL FIATELGRLD VEPFEIAVIP RGVRFTVALP
210 220 230 240 250
DGDARGYICE NFGALLRLPD LGPIGSNGLA NPRDFLTPQA AYEDREGAFE
260 270 280 290 300
LVAKLNGRLW RADIGHSPLD VVAWHGNYAP YKYDLRLFNT IGSISFDHPD
310 320 330 340 350
PSIFLVLHSQ TDTPGVDAID FVIFPPRWLA AEDTFRPPWF HRNVASEFMG
360 370 380 390 400
LVHGAYDAKA EGFVPGGASL HNCMSGHGPD ADTFEKASAS DTTKPHKVDN
410 420 430 440
TMAFMFETRT LIRPTRYALD TAQLQANYFE CWQGIRKHFN PEQR
Length:444
Mass (Da):49,008
Last modified:January 15, 2008 - v1
Checksum:i7E2FF16ADA189980
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000868 Genomic DNA Translation: ABX16247.1
AP009385 Genomic DNA Translation: BAG42638.1
RefSeqiWP_012214028.1, NC_010804.1

Genome annotation databases

EnsemblBacteriaiABX16247; ABX16247; Bmul_2563
BAG42638; BAG42638; BMULJ_00675
KEGGibmj:BMULJ_00675
bmu:Bmul_2563

Similar proteinsi

Entry informationi

Entry nameiHGD_BURM1
AccessioniPrimary (citable) accession number: A9AFM6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: January 15, 2008
Last modified: May 23, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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