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Reviewed, UniProtKB/Swiss-Prot A9AFM6 (HGD_BURM1)

Last modified November 3, 2009. Version 18. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Homogentisate 1,2-dioxygenase
    EC=1.13.11.5
Alternative name(s):
    Homogentisicase
    Homogentisate oxygenase
    Homogentisic acid oxidase
Gene names
Name: hmgA
Ordered Locus Names: Bmul_2563, BMULJ_00675
OrganismBurkholderia multivorans (strain ATCC 17616 / 249) [Complete proteome] [HAMAP]
Taxonomic identifier395019 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex

Protein attributes

Sequence length444 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

Homogentisate + O2 = 4-maleylacetoacetate. HAMAP MF_00334

Cofactor

Iron By similarity.

Pathway

Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6. HAMAP MF_00334

Sequence similarities

Belongs to the homogentisate dioxygenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 444444Homogentisate 1,2-dioxygenase HAMAP MF_00334
PRO_1000119843

Sites

Metal binding3411Iron By similarity
Metal binding3471Iron By similarity
Metal binding3771Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
A9AFM6-1 [UniParc].

Last modified January 15, 2008. Version 1.
Checksum: 7E2FF16ADA189980

FASTA44449,008
        10         20         30         40         50         60 
MTLDLSKPAT AGYLSGFANE FATEALPGAL PHGRNSPQRA PYGLYAEQLS GTAFTAPRGH 

        70         80         90        100        110        120 
NRRSWLYRIR PAAVHRPFEP FAGAQRLVSD FADSADVPPT PPNQLRWNPL PMPSEPTDFV 

       130        140        150        160        170        180 
EGLVTMAGNG SAAAMSGCAI HLYAANRSMR DRFFYSADGE LLIVPQQGRL FIATELGRLD 

       190        200        210        220        230        240 
VEPFEIAVIP RGVRFTVALP DGDARGYICE NFGALLRLPD LGPIGSNGLA NPRDFLTPQA 

       250        260        270        280        290        300 
AYEDREGAFE LVAKLNGRLW RADIGHSPLD VVAWHGNYAP YKYDLRLFNT IGSISFDHPD 

       310        320        330        340        350        360 
PSIFLVLHSQ TDTPGVDAID FVIFPPRWLA AEDTFRPPWF HRNVASEFMG LVHGAYDAKA 

       370        380        390        400        410        420 
EGFVPGGASL HNCMSGHGPD ADTFEKASAS DTTKPHKVDN TMAFMFETRT LIRPTRYALD 

       430        440 
TAQLQANYFE CWQGIRKHFN PEQR 

« Hide

References

[1]"Complete sequence of chromosome 1 of Burkholderia multivorans ATCC 17616."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Tiedje J., Richardson P.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Complete genome sequence of Burkholderia multivorans ATCC 17616."
Ohtsubo Y., Yamashita A., Kurokawa K., Takami H., Yuhara S., Nishiyama E., Endo R., Miyazaki R., Ono A., Yano K., Ito M., Sota M., Yuji N., Hattori M., Tsuda M.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

CP000868 Genomic DNA. Translation: ABX16247.1.
AP009385 Genomic DNA. Translation: BAG42638.1.
RefSeqYP_001580744.1.
YP_001945174.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID5767308.
6359849.
GenomeReviewsGene locus BMULJ_00675 in contig AP009385_GR.
Gene locus Bmul_2563 in contig CP000868_GR.
KEGGbmj:BMULJ_00675.
bmu:Bmul_2563.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAHRNCMSE.

Family and domain databases

HAMAPMF_00334.
[Tree]
InterProIPR005708. Homogentis_dOase.
[Graphical view]
PANTHERPTHR11056. Homogentis_dOase. 1 hit.
PfamPF04209. HgmA. 1 hit.
[Graphical view]
TIGRFAMsTIGR01015. hmgA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHGD_BURM1
AccessionPrimary (citable) accession number: A9AFM6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: January 15, 2008
Last modified: November 3, 2009
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents