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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Burkholderia multivorans (strain ATCC 17616 / 249)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandPyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:Bmul_0141, BMULJ_03124
OrganismiBurkholderia multivorans (strain ATCC 17616 / 249)
Taxonomic identifieri395019 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
Proteomesi
  • UP000008815 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001902101 – 975Glycine dehydrogenase (decarboxylating)Add BLAST975

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei723N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiA9ACU3

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi395019.BMULJ_03124

Structurei

3D structure databases

ProteinModelPortaliA9ACU3
SMRiA9ACU3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CBI Bacteria
COG0403 LUCA
COG1003 LUCA
HOGENOMiHOG000239369
KOiK00281
OMAiQTMVCDL
OrthoDBiPOG091H03O6

Family and domain databases

CDDicd00613 GDC-P, 2 hits
Gene3Di3.40.640.10, 2 hits
3.90.1150.10, 1 hit
HAMAPiMF_00711 GcvP, 1 hit
InterProiView protein in InterPro
IPR003437 GcvP
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11773 PTHR11773, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 2 hits
SUPFAMiSSF53383 SSF53383, 3 hits
TIGRFAMsiTIGR00461 gcvP, 1 hit

Sequencei

Sequence statusi: Complete.

A9ACU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLEHPDRLM NRTPLSLAAL ETHDAFAERH IGPDAASQQA MLDTLGFASR
60 70 80 90 100
AALIDAVIPA SIRRNETLPL GPFSQPKSEA EALAALRALA DKNQVFRSYI
110 120 130 140 150
GQGYYDTHTP AVILRNVLEN PAWYTAYTPY QPEISQGRLE ALLNFQQMVT
160 170 180 190 200
DLTGLAISNA SLLDEATAAA EAMTLLQRVG KPKSNVFYVA DDVLPQTLEV
210 220 230 240 250
IRTRALPIGI DVKTGPAADA AQSNAFGVLL QYPGVNGDVR DYRALTDAIH
260 270 280 290 300
AAGGHVVVAA DLLALTVLTP PGEWGADVAV GNTQRFGVPM GFGGPHAAYL
310 320 330 340 350
AVRDEFKRQM PGRLVGVTVD AQGKPALRLA LQTREQHIRR EKATSNVCTA
360 370 380 390 400
QALLAIMASM YAVYHGPHGL KTIALRVNRI AALFAAGVKQ LGFATVNDTF
410 420 430 440 450
FDTVTVDTGA RTAQVHAFAN AKRINLRRVS DARVGVSIDE TTTRDDLADL
460 470 480 490 500
LAVFAQAAGG TAPSVDALDA GLGGEAALPA SLVRTSAYLT HHVFNRHHSE
510 520 530 540 550
TEMLRYLRSL SDKDLALDRS MIPLGSCTMK LNATSEMLPV TWPEFGRIHP
560 570 580 590 600
FAPAEQTVGY REMIDQLEQM LVAATGYAAV SLQPNAGSQG EYAGLLIIHA
610 620 630 640 650
YHASRGEGHR DVCLIPASAH GTNPASAHMA GMKVVVVACD AQGNVDIADL
660 670 680 690 700
KAKAEQHSAN LAAIMITYPS THGVFEQNVR EICEIVHAHG GQVYVDGANM
710 720 730 740 750
NAMVGLTAPG QFGGDVSHLN LHKTFCIPHG GGGPGVGPVA VGAHLAKFLP
760 770 780 790 800
NQRSTGYTRG EDGIGAVSAA PYGSASILPI SWMYIAMMGA KNLTAATETA
810 820 830 840 850
ILNANYIAKR LAPHYPVLYS GPGGLVAHEC ILDLRPIKES SGITVDDVAK
860 870 880 890 900
RLMDYGFHAP TMSFPVPGTL MVEPTESESK EELDRFIDAM IAIRDEIRAV
910 920 930 940 950
EEGRADREDN PLRHAPHTAA VVTANEWPHA YSREQAAYPV ASLGTNKYWP
960 970
PVGRADNAYG DRNLFCACVP MSDYA
Length:975
Mass (Da):104,329
Last modified:January 15, 2008 - v1
Checksum:iB67BC9F13ED99B36
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000868 Genomic DNA Translation: ABX13836.1
AP009385 Genomic DNA Translation: BAG44998.1
RefSeqiWP_012212498.1, NC_010804.1

Genome annotation databases

EnsemblBacteriaiABX13836; ABX13836; Bmul_0141
BAG44998; BAG44998; BMULJ_03124
KEGGibmj:BMULJ_03124
bmu:Bmul_0141

Similar proteinsi

Entry informationi

Entry nameiGCSP_BURM1
AccessioniPrimary (citable) accession number: A9ACU3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: January 15, 2008
Last modified: May 23, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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