A9ABZ7 (IOLG_BURM1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inositol 2-dehydrogenase
EC=1.1.1.18

Alternative name(s):
Myo-inositol 2-dehydrogenase
Short name=MI 2-dehydrogenase

Gene names

Name:	iolG
Ordered Locus Names:	Bmul_1887, BMULJ_01354

Organism

Burkholderia multivorans (strain ATCC 17616 / 249) [Complete proteome] [HAMAP]

Taxonomic identifier

395019 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length	337 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose) By similarity. HAMAP MF_01671
Catalytic activity	Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH. HAMAP MF_01671
Subunit structure	Homotetramer By similarity. HAMAP MF_01671
Sequence similarities	Belongs to the gfo/idh/mocA family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	inositol catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	inositol 2-dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 337	337	Inositol 2-dehydrogenase HAMAP MF_01671		PRO_0000352563

Sequences

	Sequence		Length	Mass (Da)
	A9ABZ7 [UniParc]. Last modified January 15, 2008. Version 1. Checksum: 8A8698FD9DA82D9B	FASTA	337	36,843
	10 20 30 40 50 60 MTLQIGVIGC GAIGQDHIRR LMRTLSGARV VAVNDIDPQQ ARDAVTHYAP DAEIYADGRD 70 80 90 100 110 120 LIAAADVQAV LVTSWGPTHE AFVLDAIAHG KPVFCEKPLA VTADGCMRIV EAELAHGTRL 130 140 150 160 170 180 VQVGFMRPYD EGYRALKRVI DSGQIGAPLM LHCAHRNQSV GERYTTDMAI TDTLIHELDV 190 200 210 220 230 240 LRWLLGEDYV SAQVVYPKKT RHASTHLADP QIVLLETVSG VRIDVEIFVN CQYGYDIQCE 250 260 270 280 290 300 VVGENGIAKL PDPPAVGLKH LARQSVEIMT DWKERFIASY DVELQAFIDG VRRQTLTGPS 310 320 330 AWDGYAAAVA ADACVRAQKS GAVEPIAIAE RPAFYRA

References

[1]

"Complete sequence of chromosome 1 of Burkholderia multivorans ATCC 17616." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Tiedje J., Richardson P. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 17616 / 249.

[2]

"Complete genome sequence of Burkholderia multivorans ATCC 17616." Ohtsubo Y., Yamashita A., Kurokawa K., Takami H., Yuhara S., Nishiyama E., Endo R., Miyazaki R., Ono A., Yano K., Ito M., Sota M., Yuji N., Hattori M., Tsuda M. Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 17616 / 249.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000868 Genomic DNA. Translation: ABX15574.1. AP009385 Genomic DNA. Translation: BAG43290.1.
RefSeq	YP_001580071.1. NC_010084.1. YP_001945826.1. NC_010804.1.
3D structure databases
ProteinModelPortal	A9ABZ7.
ModBase	Search...
Protein-protein interaction databases
STRING	A9ABZ7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5766341. 6359568.
GenomeReviews	Gene locus BMULJ_01354 in contig AP009385_GR. Gene locus Bmul_1887 in contig CP000868_GR.
KEGG	bmj:BMULJ_01354. bmu:Bmul_1887.
PATRIC	19164484. VBIBurMul203716_2325.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG612336.
OMA	YDVELQD.
ProtClustDB	CLSK896889.
Family and domain databases
HAMAP	MF_01671. IolG. [Tree]
InterPro	IPR023794. MI/DCI_dehydrogenase. IPR016040. NAD(P)-bd_dom. IPR000683. Oxidoreductase_N. IPR004104. OxRdtase_C. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00010.
PANTHER	PTHR22604:SF7. PTHR22604:SF7. 1 hit.
Pfam	PF01408. GFO_IDH_MocA. 1 hit. PF02894. GFO_IDH_MocA_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IOLG_BURM1

Accession

Primary (citable) accession number: A9ABZ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 14, 2008
Last sequence update:	January 15, 2008
Last modified:	January 25, 2012
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program