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A9AB67

- COFG_METM6

UniProt

A9AB67 - COFG_METM6

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Protein

FO synthase subunit 1

Gene

cofG

Organism
Methanococcus maripaludis (strain C6 / ATCC BAA-1332)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO).UniRule annotation

Catalytic activityi

5-amino-6-(D-ribitylamino)uracil + 3-(4-hydroxyphenyl)pyruvate + 2 S-adenosyl-L-methionine + H2O = 7,8-didemethyl-8-hydroxy-5-deazariboflavin + 2 L-methionine + 2 5'-deoxyadenosine + oxalate + NH3.UniRule annotation

Cofactori

Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi49 – 491Iron-sulfur (4Fe-4S-S-AdoMet)UniRule annotation
Metal bindingi53 – 531Iron-sulfur (4Fe-4S-S-AdoMet)UniRule annotation
Metal bindingi56 – 561Iron-sulfur (4Fe-4S-S-AdoMet)UniRule annotation

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity Source: UniProtKB-EC
  3. iron ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. coenzyme biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciMMAR444158:GHN2-1826-MONOMER.
UniPathwayiUPA00072.

Names & Taxonomyi

Protein namesi
Recommended name:
FO synthase subunit 1UniRule annotation (EC:2.5.1.77UniRule annotation)
Alternative name(s):
7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase subunit 1UniRule annotation
Gene namesi
Name:cofGUniRule annotation
Ordered Locus Names:MmarC6_1779
OrganismiMethanococcus maripaludis (strain C6 / ATCC BAA-1332)
Taxonomic identifieri444158 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
ProteomesiUP000000791: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 352352FO synthase subunit 1PRO_1000148236Add
BLAST

Interactioni

Subunit structurei

Consists of two subunits, CofG and CofH.UniRule annotation

Protein-protein interaction databases

STRINGi444158.MmarC6_1779.

Structurei

3D structure databases

ProteinModelPortaliA9AB67.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the radical SAM superfamily. CofG family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1060.
HOGENOMiHOG000108301.
KOiK11780.
OMAiLTTACRY.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01611. FO_synth_sub1.
InterProiIPR013785. Aldolase_TIM.
IPR019939. CofG_family.
IPR006638. Elp3/MiaB/NifB.
IPR007197. rSAM.
[Graphical view]
PfamiPF04055. Radical_SAM. 1 hit.
[Graphical view]
SMARTiSM00729. Elp3. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03550. F420_cofG. 1 hit.

Sequencei

Sequence statusi: Complete.

A9AB67-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MITKSEALDF LKFNSINPIL EKLEDINTRN SSKTITFSKN AFIPVCNWCR
60 70 80 90 100
NVCGYCTFRA EDFKLLKMEE MKEILIKADV FGCREALFTF GENVDENEKV
110 120 130 140 150
KEELKKMGYS GILEYLYEIS AWCLENTNLL PHTNCGILSY DELKYLREVN
160 170 180 190 200
ASMGLMLENS SERLCSTIAH EKSPGKDPNL RIEMIENAGK LKIPFTTGIL
210 220 230 240 250
IGIGETLEER IDSIFEIKRI HEKYGNIQEV IVQNFRSKPK IPMENYKEPS
260 270 280 290 300
PVEMFKMIIL SKLILEDISI QVPPNLNRET GQLFLMAGID DWGGVSPLTK
310 320 330 340 350
DFVNPEAPWP DIEELNSFSK ELGFNLKERL PVYEKYIAEE WLDKKILEKI

KK
Length:352
Mass (Da):40,620
Last modified:January 15, 2008 - v1
Checksum:i7B4BF967BC7D15D6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000867 Genomic DNA. Translation: ABX02590.1.
RefSeqiYP_001549822.1. NC_009975.1.

Genome annotation databases

EnsemblBacteriaiABX02590; ABX02590; MmarC6_1779.
GeneIDi5737633.
KEGGimmx:MmarC6_1779.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000867 Genomic DNA. Translation: ABX02590.1 .
RefSeqi YP_001549822.1. NC_009975.1.

3D structure databases

ProteinModelPortali A9AB67.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 444158.MmarC6_1779.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX02590 ; ABX02590 ; MmarC6_1779 .
GeneIDi 5737633.
KEGGi mmx:MmarC6_1779.

Phylogenomic databases

eggNOGi COG1060.
HOGENOMi HOG000108301.
KOi K11780.
OMAi LTTACRY.

Enzyme and pathway databases

UniPathwayi UPA00072 .
BioCyci MMAR444158:GHN2-1826-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01611. FO_synth_sub1.
InterProi IPR013785. Aldolase_TIM.
IPR019939. CofG_family.
IPR006638. Elp3/MiaB/NifB.
IPR007197. rSAM.
[Graphical view ]
Pfami PF04055. Radical_SAM. 1 hit.
[Graphical view ]
SMARTi SM00729. Elp3. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03550. F420_cofG. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C6 / ATCC BAA-1332.

Entry informationi

Entry nameiCOFG_METM6
AccessioniPrimary (citable) accession number: A9AB67
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: January 15, 2008
Last modified: October 29, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3