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A9AB27

- DAPF_METM6

UniProt

A9AB27 - DAPF_METM6

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Protein

Diaminopimelate epimerase

Gene

dapF

Organism
Methanococcus maripaludis (strain C6 / ATCC BAA-1332)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine.UniRule annotation

Catalytic activityi

LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei11 – 111SubstrateUniRule annotation
Binding sitei44 – 441SubstrateUniRule annotation
Binding sitei62 – 621SubstrateUniRule annotation
Active sitei71 – 711Proton donor/acceptorUniRule annotation
Binding sitei160 – 1601SubstrateUniRule annotation
Sitei162 – 1621Important for catalytic activityUniRule annotation
Binding sitei193 – 1931SubstrateUniRule annotation
Sitei211 – 2111Important for catalytic activityUniRule annotation
Active sitei220 – 2201Proton donor/acceptorUniRule annotation

GO - Molecular functioni

  1. diaminopimelate epimerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Lysine biosynthesis

Enzyme and pathway databases

BioCyciMMAR444158:GHN2-1785-MONOMER.
UniPathwayiUPA00034; UER00025.

Names & Taxonomyi

Protein namesi
Recommended name:
Diaminopimelate epimeraseUniRule annotation (EC:5.1.1.7UniRule annotation)
Short name:
DAP epimeraseUniRule annotation
Gene namesi
Name:dapFUniRule annotation
Ordered Locus Names:MmarC6_1738
OrganismiMethanococcus maripaludis (strain C6 / ATCC BAA-1332)
Taxonomic identifieri444158 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
ProteomesiUP000000791: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 277277Diaminopimelate epimerasePRO_1000124422Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi71 ↔ 220

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi444158.MmarC6_1738.

Structurei

3D structure databases

ProteinModelPortaliA9AB27.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni8 – 92Substrate bindingUniRule annotation
Regioni71 – 733Substrate bindingUniRule annotation
Regioni211 – 2122Substrate bindingUniRule annotation
Regioni221 – 2222Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the diaminopimelate epimerase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0253.
HOGENOMiHOG000220466.
KOiK01778.
OMAiLIVEPPY.

Family and domain databases

HAMAPiMF_00197. DAP_epimerase.
InterProiIPR018510. DAP_epimerase_AS.
IPR001653. DAP_epimerase_DapF.
[Graphical view]
PANTHERiPTHR31689. PTHR31689. 1 hit.
PfamiPF01678. DAP_epimerase. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00652. DapF. 1 hit.
PROSITEiPS01326. DAP_EPIMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9AB27-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKFTKMHGLG NDYIYVDAIS QKIENPNEIS RFVSDRHFGI GSDGLVLILP
60 70 80 90 100
SDLADFKMRM FNSDGSEAEM CGNAIRCVGK FVYDKKMTDK STITIETLAG
110 120 130 140 150
IKVLEMTIEN DKVVLVKVDM GEPILKAETI PVLSEKHPVI DEEITAKDYC
160 170 180 190 200
YNFTCVSIGN PHAITYIENV EEFPLEKIGP LFEIHEKFPR KTNVEFVELI
210 220 230 240 250
DDSTVKMRVW ERGAGETLAC GTGACAVLVA SVLKGYVGRK ATVKLLGGDL
260 270
TIEWNESDNH IYMTGPATTV FEGEIDI
Length:277
Mass (Da):30,786
Last modified:January 15, 2008 - v1
Checksum:iC12BEBD53910A947
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000867 Genomic DNA. Translation: ABX02550.1.
RefSeqiWP_012194465.1. NC_009975.1.
YP_001549782.1. NC_009975.1.

Genome annotation databases

EnsemblBacteriaiABX02550; ABX02550; MmarC6_1738.
GeneIDi5737479.
KEGGimmx:MmarC6_1738.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000867 Genomic DNA. Translation: ABX02550.1 .
RefSeqi WP_012194465.1. NC_009975.1.
YP_001549782.1. NC_009975.1.

3D structure databases

ProteinModelPortali A9AB27.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 444158.MmarC6_1738.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX02550 ; ABX02550 ; MmarC6_1738 .
GeneIDi 5737479.
KEGGi mmx:MmarC6_1738.

Phylogenomic databases

eggNOGi COG0253.
HOGENOMi HOG000220466.
KOi K01778.
OMAi LIVEPPY.

Enzyme and pathway databases

UniPathwayi UPA00034 ; UER00025 .
BioCyci MMAR444158:GHN2-1785-MONOMER.

Family and domain databases

HAMAPi MF_00197. DAP_epimerase.
InterProi IPR018510. DAP_epimerase_AS.
IPR001653. DAP_epimerase_DapF.
[Graphical view ]
PANTHERi PTHR31689. PTHR31689. 1 hit.
Pfami PF01678. DAP_epimerase. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR00652. DapF. 1 hit.
PROSITEi PS01326. DAP_EPIMERASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C6 / ATCC BAA-1332.

Entry informationi

Entry nameiDAPF_METM6
AccessioniPrimary (citable) accession number: A9AB27
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: January 15, 2008
Last modified: October 29, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3