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A9AAX4

- DNLI_METM6

UniProt

A9AAX4 - DNLI_METM6

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Protein
DNA ligase
Gene
lig, MmarC6_1685
Organism
Methanococcus maripaludis (strain C6 / ATCC BAA-1332)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei250 – 2501ATP By similarity
Active sitei252 – 2521N6-AMP-lysine intermediate By similarity
Binding sitei257 – 2571ATP By similarity
Binding sitei272 – 2721ATP By similarity
Binding sitei301 – 3011ATP By similarity
Binding sitei342 – 3421ATP By similarity
Binding sitei432 – 4321ATP By similarity
Binding sitei438 – 4381ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. DNA ligation involved in DNA repair Source: InterPro
  2. DNA recombination Source: UniProtKB-HAMAP
  3. DNA replication Source: UniProtKB-HAMAP
  4. cell cycle Source: UniProtKB-KW
  5. cell division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMMAR444158:GHN2-1732-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligase (EC:6.5.1.1)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:lig
Ordered Locus Names:MmarC6_1685
OrganismiMethanococcus maripaludis (strain C6 / ATCC BAA-1332)
Taxonomic identifieri444158 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
ProteomesiUP000000791: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 573573DNA ligaseUniRule annotation
PRO_0000365252Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi444158.MmarC6_1685.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036008.
KOiK10747.
OMAiARVQVHK.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9AAX4-1 [UniParc]FASTAAdd to Basket

« Hide

MLFIDFCKIL DKIEKTTKRL EKTDYFVELI DFIKNNGKAE NLKQVSQITI    50
GRVFAEFENK EIGIGPNLLI EAVKTTGISE KDLKAEIKKT GDIGIAVENL 100
SSNIKQVSLF SQPLTLEEIY STLKKLSEIE GNSSQKKKTR IISNLLILSN 150
PVESRYISRL ILEDMRIGMN IPTILASFSN YFNVNKEAVE KIYAVTNDIG 200
LIGKKLISGS DIENDSELKL KVFRPIKPML AQLTPSIEDA IIETKMPQFE 250
TKYDGARVQV HKSNGKVNIY SRRLENITNS VPELVEEINK IDIDNIILEG 300
ECVAMDLSSG KPRPFQDILR RFRRKYDIDK VAEKIALRIY FFDVLYYEKG 350
LIDTPLKNRR EILEKLFGTN NWDSELEKIQ KEIFSNKMLF SSFKLNSDDP 400
DLAKEFFNWS LSIGHEGIMI KNPDAPYTPG SRVKTMYKVK PTLENLDVVV 450
TRAKIGMGKR KDWYGSYEIS VKDDEDNLHV IGNVGSGLTE DDLERLTTIV 500
NEIKIEDLGE EVILEPKIVL EVTYEEIQTS EKYEMGYALR FPRVVQIRED 550
KSINDINTLD DVKKIYEIER NRK 573
Length:573
Mass (Da):65,774
Last modified:January 15, 2008 - v1
Checksum:iE25F2EC289F2571D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000867 Genomic DNA. Translation: ABX02497.1.
RefSeqiYP_001549729.1. NC_009975.1.

Genome annotation databases

EnsemblBacteriaiABX02497; ABX02497; MmarC6_1685.
GeneIDi5737379.
KEGGimmx:MmarC6_1685.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000867 Genomic DNA. Translation: ABX02497.1 .
RefSeqi YP_001549729.1. NC_009975.1.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 444158.MmarC6_1685.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX02497 ; ABX02497 ; MmarC6_1685 .
GeneIDi 5737379.
KEGGi mmx:MmarC6_1685.

Phylogenomic databases

eggNOGi COG1793.
HOGENOMi HOG000036008.
KOi K10747.
OMAi ARVQVHK.

Enzyme and pathway databases

BioCyci MMAR444158:GHN2-1732-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C6 / ATCC BAA-1332.

Entry informationi

Entry nameiDNLI_METM6
AccessioniPrimary (citable) accession number: A9AAX4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: January 15, 2008
Last modified: May 14, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi