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A9AAX4 (DNLI_METM6) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
DNA ligase

EC=6.5.1.1
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene names
Name:lig
Ordered Locus Names:MmarC6_1685
OrganismMethanococcus maripaludis (strain C6 / ATCC BAA-1332) [Complete proteome] [HAMAP]
Taxonomic identifier444158 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus

Protein attributes

Sequence length573 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). HAMAP-Rule MF_00407

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 573573DNA ligase HAMAP-Rule MF_00407
PRO_0000365252

Sites

Active site2521N6-AMP-lysine intermediate By similarity
Binding site2501ATP By similarity
Binding site2571ATP By similarity
Binding site2721ATP By similarity
Binding site3011ATP By similarity
Binding site3421ATP By similarity
Binding site4321ATP By similarity
Binding site4381ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A9AAX4 [UniParc].

Last modified January 15, 2008. Version 1.
Checksum: E25F2EC289F2571D

FASTA57365,774
        10         20         30         40         50         60 
MLFIDFCKIL DKIEKTTKRL EKTDYFVELI DFIKNNGKAE NLKQVSQITI GRVFAEFENK 

        70         80         90        100        110        120 
EIGIGPNLLI EAVKTTGISE KDLKAEIKKT GDIGIAVENL SSNIKQVSLF SQPLTLEEIY 

       130        140        150        160        170        180 
STLKKLSEIE GNSSQKKKTR IISNLLILSN PVESRYISRL ILEDMRIGMN IPTILASFSN 

       190        200        210        220        230        240 
YFNVNKEAVE KIYAVTNDIG LIGKKLISGS DIENDSELKL KVFRPIKPML AQLTPSIEDA 

       250        260        270        280        290        300 
IIETKMPQFE TKYDGARVQV HKSNGKVNIY SRRLENITNS VPELVEEINK IDIDNIILEG 

       310        320        330        340        350        360 
ECVAMDLSSG KPRPFQDILR RFRRKYDIDK VAEKIALRIY FFDVLYYEKG LIDTPLKNRR 

       370        380        390        400        410        420 
EILEKLFGTN NWDSELEKIQ KEIFSNKMLF SSFKLNSDDP DLAKEFFNWS LSIGHEGIMI 

       430        440        450        460        470        480 
KNPDAPYTPG SRVKTMYKVK PTLENLDVVV TRAKIGMGKR KDWYGSYEIS VKDDEDNLHV 

       490        500        510        520        530        540 
IGNVGSGLTE DDLERLTTIV NEIKIEDLGE EVILEPKIVL EVTYEEIQTS EKYEMGYALR 

       550        560        570 
FPRVVQIRED KSINDINTLD DVKKIYEIER NRK 

« Hide

References

[1]"Complete sequence of Methanococcus maripaludis C6."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Sieprawska-Lupa M., Whitman W.B., Richardson P.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C6 / ATCC BAA-1332.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000867 Genomic DNA. Translation: ABX02497.1.
RefSeqYP_001549729.1. NC_009975.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING444158.MmarC6_1685.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABX02497; ABX02497; MmarC6_1685.
GeneID5737379.
KEGGmmx:MmarC6_1685.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1793.
HOGENOMHOG000036008.
KOK10747.
OMAARVQVHK.

Enzyme and pathway databases

BioCycMMAR444158:GHN2-1732-MONOMER.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDNLI_METM6
AccessionPrimary (citable) accession number: A9AAX4
Entry history
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: January 15, 2008
Last modified: May 14, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families