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A9AAT7

- SYE_METM6

UniProt

A9AAT7 - SYE_METM6

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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Methanococcus maripaludis (strain C6 / ATCC BAA-1332)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMMAR444158:GHN2-1695-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:MmarC6_1648
OrganismiMethanococcus maripaludis (strain C6 / ATCC BAA-1332)
Taxonomic identifieri444158 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
ProteomesiUP000000791: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 555555Glutamate--tRNA ligasePRO_1000090088Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi444158.MmarC6_1648.

Structurei

3D structure databases

ProteinModelPortaliA9AAT7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi100 – 11011"HIGH" regionAdd
BLAST

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0008.
HOGENOMiHOG000073585.
KOiK01885.
OMAiYLGWDDP.

Family and domain databases

Gene3Di1.10.1160.10. 1 hit.
2.40.240.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00022_A. Glu_tRNA_synth_A.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR004526. Glu-tRNA-synth_arc/euk.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR022888. Glu_tRNA_synth_arc.
IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR10119. PTHR10119. 1 hit.
PfamiPF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF50715. SSF50715. 1 hit.
TIGRFAMsiTIGR00463. gltX_arch. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9AAT7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKDTVMAYLL ENSIKFKGKP NPKAAMGKIL GENPDLRSKV KEVNEVISEV
60 70 80 90 100
LKEIETMSLE EQQAKLDELA PEGLGQKTER KRKEIELKNV KGNVAMRFAP
110 120 130 140 150
NPSGPLHIGH ARASVLNDFF TKKYNGKLVL RLEDTDAKRV LPEAYEMIQE
160 170 180 190 200
DLNWLGVKVD EVIVQSERLE IYYEYGRKLI EMGHAYVCDC DAEEFRNLRE
210 220 230 240 250
QGIPCKCRDA TPEENIVLWE KMLSGEVENV AVRLKTDIAH KNPSIRDFPI
260 270 280 290 300
FRIERTPHPK NGTKYHVYPL MNLSVTVDDH LLGMTHVLRG KDHIVNTEKQ
310 320 330 340 350
EYIYNYFGWE IPEYIHYGIL KIEGPVLSTS KMHAGILSGE YSGWDDARLG
360 370 380 390 400
TLRALRKRGI RPEALYKLMV EIGIKQADVR FAWENLYAAN KDVIDKDARR
410 420 430 440 450
FFFVESPKKV VISGAENKKI DLRMHPDRSE LGNRELLFDG EIYVSDDLEA
460 470 480 490 500
GKMYRLMELF NIVVERIEND IIYAKYDSDD LAVAKSNRAS IIHWIPVKDS
510 520 530 540 550
IPVTVIDENA ENIEGFAEKD FAVVKKDDFV QFERFGFVRV DEKEDNGYIC

YLTHK
Length:555
Mass (Da):63,941
Last modified:January 15, 2008 - v1
Checksum:i246BAF3D2176CA6B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000867 Genomic DNA. Translation: ABX02460.1.
RefSeqiWP_012194375.1. NC_009975.1.
YP_001549692.1. NC_009975.1.

Genome annotation databases

EnsemblBacteriaiABX02460; ABX02460; MmarC6_1648.
GeneIDi5737740.
KEGGimmx:MmarC6_1648.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000867 Genomic DNA. Translation: ABX02460.1 .
RefSeqi WP_012194375.1. NC_009975.1.
YP_001549692.1. NC_009975.1.

3D structure databases

ProteinModelPortali A9AAT7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 444158.MmarC6_1648.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX02460 ; ABX02460 ; MmarC6_1648 .
GeneIDi 5737740.
KEGGi mmx:MmarC6_1648.

Phylogenomic databases

eggNOGi COG0008.
HOGENOMi HOG000073585.
KOi K01885.
OMAi YLGWDDP.

Enzyme and pathway databases

BioCyci MMAR444158:GHN2-1695-MONOMER.

Family and domain databases

Gene3Di 1.10.1160.10. 1 hit.
2.40.240.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPi MF_00022_A. Glu_tRNA_synth_A.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR004526. Glu-tRNA-synth_arc/euk.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR022888. Glu_tRNA_synth_arc.
IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR10119. PTHR10119. 1 hit.
Pfami PF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
[Graphical view ]
PRINTSi PR00987. TRNASYNTHGLU.
SUPFAMi SSF50715. SSF50715. 1 hit.
TIGRFAMsi TIGR00463. gltX_arch. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C6 / ATCC BAA-1332.

Entry informationi

Entry nameiSYE_METM6
AccessioniPrimary (citable) accession number: A9AAT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: January 15, 2008
Last modified: October 29, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3