A9AAP6 (SURE_METM6) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
5'-nucleotidase surE
EC=3.1.3.5

Alternative name(s):
Nucleoside 5'-monophosphate phosphohydrolase

Gene names

Name:	surE
Ordered Locus Names:	MmarC6_1607

Organism

Methanococcus maripaludis (strain C6 / ATCC BAA-1332) [Complete proteome] [HAMAP]

Taxonomic identifier

444158 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanococcaceae › Methanococcus

Protein attributes

Sequence length	264 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates By similarity. HAMAP MF_00060
Catalytic activity	A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate. HAMAP MF_00060
Cofactor	Binds 1 divalent metal cation per subunit By similarity.
Subcellular location	Cytoplasm Potential HAMAP MF_00060.
Sequence similarities	Belongs to the surE nucleotidase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	5'-nucleotidase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 264	264	5'-nucleotidase surE HAMAP MF_00060		PRO_1000092017
Sites
	Metal binding	10	1	Divalent metal cation By similarity
	Metal binding	11	1	Divalent metal cation By similarity
	Metal binding	43	1	Divalent metal cation By similarity
	Metal binding	99	1	Divalent metal cation By similarity

Sequences

	Sequence		Length	Mass (Da)
	A9AAP6 [UniParc]. Last modified January 15, 2008. Version 1. Checksum: 6F4032B29167A3FD	FASTA	264	29,246
	10 20 30 40 50 60 MTMEILLVND DGIYSNGLLA LKNVISEEFD ANVTVVAPTN QQSGIGRAIS LFEPLRITKT 70 80 90 100 110 120 KLADCSEGYA VSGTPTDCVV LGVHQVLKKV PDYVISGINI GENLGTELTT SGTLGAAFEG 130 140 150 160 170 180 AHHGAKALAC SLQVTTDHLK FKEGESPIDF MTTARIVRNV FKKFLDDEFP CDVININVPD 190 200 210 220 230 240 NATENTPVEI TKLARKMYSM HVEERIDPRS RSYYWLDGYP IMDEEDGTDV YAVRNKRNVS 250 260 VTPLTLDNTA KNLDEFREKY AKKF

References

[1]

"Complete sequence of Methanococcus maripaludis C6." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Sieprawska-Lupa M., Whitman W.B., Richardson P. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C6 / ATCC BAA-1332.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000867 Genomic DNA. Translation: ABX02419.1.
RefSeq	YP_001549651.1. NC_009975.1.
3D structure databases
ProteinModelPortal	A9AAP6.
ModBase	Search...
Protein-protein interaction databases
STRING	A9AAP6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5737601.
GenomeReviews	Gene locus MmarC6_1607 in contig CP000867_GR.
KEGG	mmx:MmarC6_1607.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG600532.
OMA	NINIPEN.
ProtClustDB	PRK00346.
Enzyme and pathway databases
BioCyc	MMAR444158:MMARC6_1607-MONOMER.
Family and domain databases
HAMAP	MF_00060. SurE. [Tree]
InterPro	IPR002828. SurE-like_Pase/nucleotidase. [Graphical view]
Gene3D	G3DSA:3.40.1210.10. SurE-like_Pase/nucleotidase. 1 hit.
KO	K03787.
Pfam	PF01975. SurE. 1 hit. [Graphical view]
SUPFAM	SSF64167. SurE-like_Pase/nucleotidase. 1 hit.
TIGRFAMs	TIGR00087. SurE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SURE_METM6

Accession

Primary (citable) accession number: A9AAP6

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	January 15, 2008
Last modified:	January 25, 2012
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program