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A9AAH0

- THIM_METM6

UniProt

A9AAH0 - THIM_METM6

Protein

Hydroxyethylthiazole kinase

Gene

thiM

Organism
Methanococcus maripaludis (strain C6 / ATCC BAA-1332)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (15 Jan 2008)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).UniRule annotation

    Catalytic activityi

    ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei43 – 431Substrate; via amide nitrogenUniRule annotation
    Binding sitei119 – 1191ATPUniRule annotation
    Binding sitei166 – 1661ATPUniRule annotation
    Binding sitei193 – 1931Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. hydroxyethylthiazole kinase activity Source: UniProtKB-HAMAP
    3. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. thiamine biosynthetic process Source: UniProtKB-KW
    2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Thiamine biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMMAR444158:GHN2-1576-MONOMER.
    UniPathwayiUPA00060; UER00139.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hydroxyethylthiazole kinaseUniRule annotation (EC:2.7.1.50UniRule annotation)
    Alternative name(s):
    4-methyl-5-beta-hydroxyethylthiazole kinaseUniRule annotation
    Short name:
    TH kinaseUniRule annotation
    Short name:
    Thz kinaseUniRule annotation
    Gene namesi
    Name:thiMUniRule annotation
    Ordered Locus Names:MmarC6_1530
    OrganismiMethanococcus maripaludis (strain C6 / ATCC BAA-1332)
    Taxonomic identifieri444158 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
    ProteomesiUP000000791: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 266266Hydroxyethylthiazole kinasePRO_1000100417Add
    BLAST

    Proteomic databases

    PRIDEiA9AAH0.

    Interactioni

    Protein-protein interaction databases

    STRINGi444158.MmarC6_1530.

    Structurei

    3D structure databases

    ProteinModelPortaliA9AAH0.
    SMRiA9AAH0. Positions 1-265.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Thz kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2145.
    HOGENOMiHOG000114352.
    KOiK00878.
    OMAiQTFTANV.

    Family and domain databases

    Gene3Di3.40.1190.20. 1 hit.
    HAMAPiMF_00228. Thz_kinase.
    InterProiIPR000417. Hyethyz_kinase.
    IPR029056. Ribokinase-like.
    [Graphical view]
    PfamiPF02110. HK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000513. Thz_kinase. 1 hit.
    PRINTSiPR01099. HYETHTZKNASE.
    SUPFAMiSSF53613. SSF53613. 1 hit.
    TIGRFAMsiTIGR00694. thiM. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A9AAH0-1 [UniParc]FASTAAdd to Basket

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    MDFVAKNLTK LRETNPLVQN ITNYVVMNST ANSLLALGAS PVMAHAMDEL    50
    EEMVSIASSL VINIGTLDEY WIPPMEKAAK IASDLKKPII LDPVGAGATK 100
    LRTNTALKIL DFADISVLRG NFGEIAAVLG EHGKTKGVDS AAYDSNEAIE 150
    LSKNAAKEFN TVSAVTGPID YVSNGKEIYA ISNGHPMLSK VTGTGCATTS 200
    IIGAFSAVDE PIKAAVSGLT VYGISAEMAF GEAPYPGTFQ AKVYDWLYRI 250
    DEELVLEKAK VNKFEI 266
    Length:266
    Mass (Da):28,397
    Last modified:January 15, 2008 - v1
    Checksum:iE7E9B5903BAB20ED
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000867 Genomic DNA. Translation: ABX02343.1.
    RefSeqiYP_001549575.1. NC_009975.1.

    Genome annotation databases

    EnsemblBacteriaiABX02343; ABX02343; MmarC6_1530.
    GeneIDi5737788.
    KEGGimmx:MmarC6_1530.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000867 Genomic DNA. Translation: ABX02343.1 .
    RefSeqi YP_001549575.1. NC_009975.1.

    3D structure databases

    ProteinModelPortali A9AAH0.
    SMRi A9AAH0. Positions 1-265.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 444158.MmarC6_1530.

    Proteomic databases

    PRIDEi A9AAH0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABX02343 ; ABX02343 ; MmarC6_1530 .
    GeneIDi 5737788.
    KEGGi mmx:MmarC6_1530.

    Phylogenomic databases

    eggNOGi COG2145.
    HOGENOMi HOG000114352.
    KOi K00878.
    OMAi QTFTANV.

    Enzyme and pathway databases

    UniPathwayi UPA00060 ; UER00139 .
    BioCyci MMAR444158:GHN2-1576-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1190.20. 1 hit.
    HAMAPi MF_00228. Thz_kinase.
    InterProi IPR000417. Hyethyz_kinase.
    IPR029056. Ribokinase-like.
    [Graphical view ]
    Pfami PF02110. HK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000513. Thz_kinase. 1 hit.
    PRINTSi PR01099. HYETHTZKNASE.
    SUPFAMi SSF53613. SSF53613. 1 hit.
    TIGRFAMsi TIGR00694. thiM. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C6 / ATCC BAA-1332.

    Entry informationi

    Entry nameiTHIM_METM6
    AccessioniPrimary (citable) accession number: A9AAH0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3