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A9AAG3 (A9AAG3_METM6) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Amidophosphoribosyltransferase PIRNR PIRNR000485
Short name=ATase PIRNR PIRNR000485
EC=2.4.2.14 PIRNR PIRNR000485
Alternative name(s):
Glutamine phosphoribosylpyrophosphate amidotransferase PIRNR PIRNR000485
Gene names
Ordered Locus Names:MmarC6_1523
OrganismMethanococcus maripaludis (strain C6 / ATCC BAA-1332) [Complete proteome] [HAMAP]
Taxonomic identifier444158 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanococci › Methanococcales › Methanococcaceae › Methanococcus

Protein attributes

Sequence length459 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O. PIRNR PIRNR000485

Cofactor

Binds 1 4Fe-4S cluster per subunit By similarity. PIRSR PIRSR000485-3

Binds 1 magnesium ion per subunit By similarity. PIRNR PIRNR000485

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2. PIRNR PIRNR000485

Sequence similarities

In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. PIRNR PIRNR000485

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site21For GATase activity By similarity PIRSR PIRSR000485-1
Metal binding2411Iron-sulfur (4Fe-4S) By similarity PIRSR PIRSR000485-3
Metal binding3871Iron-sulfur (4Fe-4S) By similarity PIRSR PIRSR000485-3
Metal binding4361Iron-sulfur (4Fe-4S) By similarity PIRSR PIRSR000485-3
Metal binding4391Iron-sulfur (4Fe-4S) By similarity PIRSR PIRSR000485-3

Sequences

Sequence LengthMass (Da)Tools
A9AAG3 [UniParc].

Last modified January 15, 2008. Version 1.
Checksum: 7BFBE139008998DC

FASTA45950,557
        10         20         30         40         50         60 
MCGIFGIYSH EKSNIVKKVY YGLYALQHRG QEGAGIAVGN GKEIGHYKGL GLVPEVFSNK 

        70         80         90        100        110        120 
ELQNLYGHIG VGHVRYSTTG GNVIDNCQPF VVNSTFGKIA IAHNGDIVNS KELKYELEKK 

       130        140        150        160        170        180 
GHIFVSTTDS EVIAQLLVRE LLKNDDIITA VTNVTQKLNG AYSLLIIYDD TLIALRDPNG 

       190        200        210        220        230        240 
FKPLCIGKDD GAYYFSSESC ALDIVDVEFE RDVAPGEMVV VNKDGFNTYK LPNAQEKAST 

       250        260        270        280        290        300 
CMFEYVYFAR PDSVIDGISV YAVRRNIGKI LAREAPEEVD IVSPVPDSGI IFSQGYTEEA 

       310        320        330        340        350        360 
EIPYYEALIK NRYIGRTFIL PTQEERDLAV RLKLNPVKHL LKDKKVILID DSIVRGTTSG 

       370        380        390        400        410        420 
KIMKMVKKAG AKAVHLRIGS PRIVSPCFYG IDMATTKELI ANSKTNEEIA EMIGADSVAY 

       430        440        450 
LSVEGLVEAI GRDDLCLACL NGEYPTDVSC KFECGNCKK

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References

[1]"Complete sequence of Methanococcus maripaludis C6."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Sieprawska-Lupa M., Whitman W.B., Richardson P.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C6 / ATCC BAA-1332.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000867 Genomic DNA. Translation: ABX02336.1.
RefSeqYP_001549568.1. NC_009975.1.

3D structure databases

ProteinModelPortalA9AAG3.
ModBaseSearch...

Protein-protein interaction databases

STRINGA9AAG3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5737623.
GenomeReviewsGene locus MmarC6_1523 in contig CP000867_GR.
KEGGmmx:MmarC6_1523.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG392416.
OMAVWAPGEE.
ProtClustDBCLSK876109.

Family and domain databases

InterProIPR005854. Amd_phspho_trans.
IPR000583. GATase_2.
IPR017932. GATase_II.
IPR000836. PRibTrfase.
[Graphical view]
KOK00764.
PANTHERPTHR11907. Amd_phspho_trans. 1 hit.
PfamPF00310. GATase_2. 2 hits.
PF00156. Pribosyltran. 1 hit.
[Graphical view]
PIRSFPIRSF000485. Amd_phspho_trans. 1 hit.
TIGRFAMsTIGR01134. PurF. 1 hit.
PROSITEPS51278. GATASE_TYPE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA9AAG3_METM6
AccessionPrimary (citable) accession number: A9AAG3
Entry history
Integrated into UniProtKB/TrEMBL: January 15, 2008
Last sequence update: January 15, 2008
Last modified: January 25, 2012
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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