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Protein

Cobalt-precorrin-5B C(1)-methyltransferase

Gene

cbiD

Organism
Methanococcus maripaludis (strain C6 / ATCC BAA-1332)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.UniRule annotation

Catalytic activityi

Cobalt-precorrin-5B + S-adenosyl-L-methionine = cobalt-precorrin-6A + S-adenosyl-L-homocysteine.UniRule annotation

Pathwayi: adenosylcobalamin biosynthesis

This protein is involved in step 6 of the subpathway that synthesizes cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route).UniRule annotation
Proteins known to be involved in the 10 steps of the subpathway in this organism are:
  1. Sirohydrochlorin cobaltochelatase (cbiX)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
  6. Cobalt-precorrin-5B C(1)-methyltransferase (cbiD)
  7. no protein annotated in this organism
  8. Probable cobalt-precorrin-6B C(15)-methyltransferase (decarboxylating) (cbiT)
  9. no protein annotated in this organism
  10. Cobyrinate a,c-diamide synthase (cbiA)
This subpathway is part of the pathway adenosylcobalamin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route), the pathway adenosylcobalamin biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processCobalamin biosynthesis
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciMMAR444158:G1GAE-1510-MONOMER
UniPathwayiUPA00148; UER00227

Names & Taxonomyi

Protein namesi
Recommended name:
Cobalt-precorrin-5B C(1)-methyltransferaseUniRule annotation (EC:2.1.1.195UniRule annotation)
Alternative name(s):
Cobalt-precorrin-6A synthaseUniRule annotation
Gene namesi
Name:cbiDUniRule annotation
Ordered Locus Names:MmarC6_1470
OrganismiMethanococcus maripaludis (strain C6 / ATCC BAA-1332)
Taxonomic identifieri444158 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000000791 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001337391 – 365Cobalt-precorrin-5B C(1)-methyltransferaseAdd BLAST365

Interactioni

Protein-protein interaction databases

STRINGi444158.MmarC6_1470

Structurei

3D structure databases

ProteinModelPortaliA9AAB0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CbiD family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04383 Archaea
COG1903 LUCA
HOGENOMiHOG000009126
KOiK02188
OMAiGGIFHTH
OrthoDBiPOG093Z05FA

Family and domain databases

Gene3Di3.30.2110.10, 1 hit
HAMAPiMF_00787 CbiD, 1 hit
InterProiView protein in InterPro
IPR002748 CbiD
IPR036074 CbiD_sf
PANTHERiPTHR35863 PTHR35863, 1 hit
PfamiView protein in Pfam
PF01888 CbiD, 1 hit
PIRSFiPIRSF026782 CbiD, 1 hit
SUPFAMiSSF111342 SSF111342, 1 hit
TIGRFAMsiTIGR00312 cbiD, 1 hit

Sequencei

Sequence statusi: Complete.

A9AAB0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKIDFRLEK TFGYTTGACA AAGAYSALYF LKNNEKLNFV EILNLKGDSL
60 70 80 90 100
IIPIKNIEKR GNTAVSTVEK FAGEDIDITN GMDIKIEVIL ENWDDGYPKP
110 120 130 140 150
SNVIIIGGTG VGLITKSGLQ IKPGDHAINP KPREMIETNL KSLLKDDEYV
160 170 180 190 200
TVKISVPTGD EIAKKTLNPK LGIVGGISIL GTTGIVRPMS NEAYKESLAP
210 220 230 240 250
QIDVALANNF ENLIFVPGNI GTKHAKILLN AEEDQIIEVS NFWDYMLDKA
260 270 280 290 300
KEKGVKDIMV FGHAGKIVKL AGGIFDTHSR VADARNEILC AYASLVSQDV
310 320 330 340 350
EMLQKILQSN TTEDIVEILT EKGILSEVFN KVSKRVVERL SLRWEGINFS
360
CIVIDMKGNI LGKSD
Length:365
Mass (Da):40,017
Last modified:January 15, 2008 - v1
Checksum:i39FB0C7AA9BAF99E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000867 Genomic DNA Translation: ABX02283.1
RefSeqiWP_012194203.1, NC_009975.1

Genome annotation databases

EnsemblBacteriaiABX02283; ABX02283; MmarC6_1470
GeneIDi5737515
KEGGimmx:MmarC6_1470

Similar proteinsi

Entry informationi

Entry nameiCBID_METM6
AccessioniPrimary (citable) accession number: A9AAB0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: January 15, 2008
Last modified: March 28, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health