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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Methanococcus maripaludis (strain C6 / ATCC BAA-1332)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylformylglycinamidine synthase subunit PurQ (purQ), Phosphoribosylformylglycinamidine synthase subunit PurL (purL)
  2. Phosphoribosylformylglycinamidine cyclo-ligase (purM)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processPurine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMMAR444158:G1GAE-1459-MONOMER
UniPathwayiUPA00074; UER00129

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotation
Ordered Locus Names:MmarC6_1419
OrganismiMethanococcus maripaludis (strain C6 / ATCC BAA-1332)
Taxonomic identifieri444158 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000000791 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001930611 – 349Phosphoribosylformylglycinamidine cyclo-ligaseAdd BLAST349

Interactioni

Protein-protein interaction databases

STRINGi444158.MmarC6_1419

Structurei

3D structure databases

ProteinModelPortaliA9AA59
SMRiA9AA59
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00639 Archaea
COG0150 LUCA
HOGENOMiHOG000229091
KOiK01933
OMAiNHCVNDI
OrthoDBiPOG093Z0833

Family and domain databases

CDDicd02196 PurM, 1 hit
Gene3Di3.30.1330.101 hit
3.90.650.101 hit
HAMAPiMF_00741 AIRS, 1 hit
InterProiView protein in InterPro
IPR010918 PurM-like_C_dom
IPR036676 PurM-like_C_sf
IPR016188 PurM-like_N
IPR036921 PurM-like_N_sf
IPR004733 PurM_cligase
PANTHERiPTHR10520 PTHR10520, 1 hit
PfamiView protein in Pfam
PF00586 AIRS, 1 hit
PF02769 AIRS_C, 1 hit
SUPFAMiSSF55326 SSF55326, 1 hit
SSF56042 SSF56042, 1 hit
TIGRFAMsiTIGR00878 purM, 1 hit

Sequencei

Sequence statusi: Complete.

A9AA59-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTYKDAGVD IYKEDKVIRA LASQIKFERT DAIKPADLKG HYAGAIEFGD
60 70 80 90 100
YYLVLCTDGV GSKMVVAEMA NKFDTVPIDM IAMNVNDAIC IGAEPVALVD
110 120 130 140 150
YMAVEDITED IASQIGKGLN DGIKESNINL IGGETASLPN MIKGVDLAGT
160 170 180 190 200
VLAVVKKDEI VSGKEVKPGD VIVGLRSSGI HSNGLSLARK VFFDITNLDV
210 220 230 240 250
NSKLSHGKTV AEELLTPTKI YVKPVLEMIK QVNVKGLAHI TGGGFRKLKR
260 270 280 290 300
LNKDVCYKID ELPEILPIFK EIQNLGNVAD QEMFKTFNMG IGFCVIVEKE
310 320 330 340
DAEKIIEIAN HHNIPAFVIG KIEDSVEIGG KTKRETVLVE YNNKKMIME
Length:349
Mass (Da):38,145
Last modified:January 15, 2008 - v1
Checksum:i26903857D566BAB5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000867 Genomic DNA Translation: ABX02232.1
RefSeqiWP_012194152.1, NC_009975.1

Genome annotation databases

EnsemblBacteriaiABX02232; ABX02232; MmarC6_1419
GeneIDi5739143
KEGGimmx:MmarC6_1419

Similar proteinsi

Entry informationi

Entry nameiPUR5_METM6
AccessioniPrimary (citable) accession number: A9AA59
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: January 15, 2008
Last modified: February 28, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome