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A9A8Q7 (MPTA_METM6) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
GTP cyclohydrolase MptA
EC=3.5.4.n2
Gene names
Name:mptA
Ordered Locus Names:MmarC6_0915
OrganismMethanococcus maripaludis (strain C6 / ATCC BAA-1332) [Complete proteome] [HAMAP]
Taxonomic identifier444158 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanococci › Methanococcales › Methanococcaceae › Methanococcus ›

Protein attributes

Sequence length315 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin By similarity. HAMAP-Rule MF_01527

Catalytic activity

GTP + H2O = formate + 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate + diphosphate. HAMAP-Rule MF_01527

Cofactor

Binds 1 Fe2+ ion per subunit By similarity. HAMAP-Rule MF_01527

Pathway

Cofactor biosynthesis; 5,6,7,8-tetrahydromethanopterin biosynthesis. HAMAP-Rule MF_01527

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01527

Sequence similarities

Belongs to the GTP cyclohydrolase IV family.

Ontologies

Keywords
   LigandIron
Metal-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functionGTP cyclohydrolase activity

Inferred from electronic annotation. Source: HAMAP

iron ion binding

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 315315GTP cyclohydrolase MptA HAMAP-Rule MF_01527
PRO_0000372042

Sites

Site1611May be catalytically important By similarity

Sequences

Sequence LengthMass (Da)Tools
A9A8Q7 [UniParc].

Last modified January 15, 2008. Version 1.
Checksum: 261739D92768E857

FASTA31535,758
        10         20         30         40         50         60 
MQCNDVQATE PDIKVSLTRV GVTNLKKLVK LKRTNKRDIV LLPTFEVFVD LPSSQKGIHM 

        70         80         90        100        110        120 
SRSPEVIEEV VENILLEKEI YGVEDLSVEI VMKLFEKHEY ATRAEIMLYS DYMMEEKSPV 

       130        140        150        160        170        180 
TQKDSQEIGK IIARAYGVKD ENGKIHVKKM VGAEVVGITA CPCAQNMLKE NAVTSLKEKG 

       190        200        210        220        230        240 
FSNEEIEKIL DSVTIATHNQ RGIGTVMIEV PNGYTVGISK IIKIIKDSMS GEVYELLKRS 

       250        260        270        280        290        300 
DEAFVVETAH KNPKFVEDCA REMIKRVVDV FDYLPEDTQV LVRQVNKESI HRHDAFAERN 

       310 
STLRELRDEL KTLTN

« Hide

References

[1]"Complete sequence of Methanococcus maripaludis C6."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Sieprawska-Lupa M., Whitman W.B., Richardson P.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C6 / ATCC BAA-1332.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000867 Genomic DNA. Translation: ABX01730.1.
RefSeqYP_001548962.1. NC_009975.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING444158.MmarC6_0915.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABX01730; ABX01730; MmarC6_0915.
GeneID5737891.
KEGGmmx:MmarC6_0915.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1469.
HOGENOMHOG000280680.
KOK09007.
OMAVEDCVRE.
ProtClustDBPRK13675.

Enzyme and pathway databases

BioCycMMAR444158:GHN2-933-MONOMER.
UniPathwayUPA00065.

Family and domain databases

Gene3D3.10.270.10. 1 hit.
HAMAPMF_01527_A. GTP_cyclohydrol_A.
InterProIPR003801. GTP_cyclohydrolase_FolE2/MptA.
IPR022840. GTP_cyclohydrolase_MptA.
IPR002042. Uricase.
[Graphical view]
PfamPF02649. GCHY-1. 1 hit.
[Graphical view]
TIGRFAMsTIGR00294. TIGR00294. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMPTA_METM6
AccessionPrimary (citable) accession number: A9A8Q7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: January 15, 2008
Last modified: May 29, 2013
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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