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A9A8Q0

- TF2B_METM6

UniProt

A9A8Q0 - TF2B_METM6

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Protein

Transcription initiation factor IIB

Gene

tfb

Organism
Methanococcus maripaludis (strain C6 / ATCC BAA-1332)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).UniRule annotation

Cofactori

Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi43 – 431ZincUniRule annotation
Metal bindingi46 – 461ZincUniRule annotation
Metal bindingi62 – 621ZincUniRule annotation
Metal bindingi65 – 651ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri39 – 7032TFIIB-typeUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding transcription factor activity Source: UniProtKB-HAMAP
  2. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA-templated transcription, initiation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciMMAR444158:GHN2-926-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor IIBUniRule annotation
Short name:
TFIIBUniRule annotation
Gene namesi
Name:tfbUniRule annotation
Ordered Locus Names:MmarC6_0908
OrganismiMethanococcus maripaludis (strain C6 / ATCC BAA-1332)
Taxonomic identifieri444158 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
ProteomesiUP000000791: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 339339Transcription initiation factor IIBPRO_1000122400Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi444158.MmarC6_0908.

Structurei

3D structure databases

ProteinModelPortaliA9A8Q0.
SMRiA9A8Q0. Positions 143-339.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati156 – 239841Add
BLAST
Repeati250 – 331822Add
BLAST

Sequence similaritiesi

Belongs to the TFIIB family.UniRule annotation
Contains 1 TFIIB-type zinc finger.UniRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri39 – 7032TFIIB-typeUniRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG1405.
HOGENOMiHOG000108633.
KOiK03124.
OMAiWRAFDHD.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
HAMAPiMF_00383. TF2B_arch.
InterProiIPR013763. Cyclin-like.
IPR000812. TFIIB.
IPR023484. TFIIB_arc.
IPR023486. TFIIB_CS.
IPR013150. TFIIB_cyclin.
IPR013137. Znf_TFIIB.
[Graphical view]
PANTHERiPTHR11618. PTHR11618. 1 hit.
PfamiPF08271. TF_Zn_Ribbon. 1 hit.
PF00382. TFIIB. 2 hits.
[Graphical view]
PRINTSiPR00685. TIFACTORIIB.
SMARTiSM00385. CYCLIN. 2 hits.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00782. TFIIB. 2 hits.
PS51134. ZF_TFIIB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9A8Q0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKVEAITKEE TKKPERKIKL AIAKPEDYSN KNVILEKEEE LICPVCGSKN
60 70 80 90 100
IIKDYERAEI VCEMCGCVLQ QNLFDVGPEW RAFDHEQRVK RSRVGAPMTY
110 120 130 140 150
TIHDKGLSTV IDWRNKDSYG KDISADKRAQ LYRLRKWQRR IRVSDASERN
160 170 180 190 200
LAFALSELDR IASKLGLPRN VRENAAVLYR GAVEKGLIRG RSIEGVAAAA
210 220 230 240 250
LYAACRRCKV PRTLDEIAEV SRVDRKEIGR TYRFISRELN IRLAPTNPVD
260 270 280 290 300
YVPRFASELK LPGEVESKAI SILQKAGEKG LTSGRGPTGV AAAAIYIASV
310 320 330
LQGTRRTQRE VADVAGVTEV TIRNRYKELT EHLDIDVTL
Length:339
Mass (Da):38,227
Last modified:January 15, 2008 - v1
Checksum:iC1A1C03435A5B95A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000867 Genomic DNA. Translation: ABX01723.1.
RefSeqiYP_001548955.1. NC_009975.1.

Genome annotation databases

EnsemblBacteriaiABX01723; ABX01723; MmarC6_0908.
GeneIDi5738226.
KEGGimmx:MmarC6_0908.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000867 Genomic DNA. Translation: ABX01723.1 .
RefSeqi YP_001548955.1. NC_009975.1.

3D structure databases

ProteinModelPortali A9A8Q0.
SMRi A9A8Q0. Positions 143-339.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 444158.MmarC6_0908.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX01723 ; ABX01723 ; MmarC6_0908 .
GeneIDi 5738226.
KEGGi mmx:MmarC6_0908.

Phylogenomic databases

eggNOGi COG1405.
HOGENOMi HOG000108633.
KOi K03124.
OMAi WRAFDHD.

Enzyme and pathway databases

BioCyci MMAR444158:GHN2-926-MONOMER.

Family and domain databases

Gene3Di 1.10.472.10. 2 hits.
HAMAPi MF_00383. TF2B_arch.
InterProi IPR013763. Cyclin-like.
IPR000812. TFIIB.
IPR023484. TFIIB_arc.
IPR023486. TFIIB_CS.
IPR013150. TFIIB_cyclin.
IPR013137. Znf_TFIIB.
[Graphical view ]
PANTHERi PTHR11618. PTHR11618. 1 hit.
Pfami PF08271. TF_Zn_Ribbon. 1 hit.
PF00382. TFIIB. 2 hits.
[Graphical view ]
PRINTSi PR00685. TIFACTORIIB.
SMARTi SM00385. CYCLIN. 2 hits.
[Graphical view ]
SUPFAMi SSF47954. SSF47954. 2 hits.
PROSITEi PS00782. TFIIB. 2 hits.
PS51134. ZF_TFIIB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C6 / ATCC BAA-1332.

Entry informationi

Entry nameiTF2B_METM6
AccessioniPrimary (citable) accession number: A9A8Q0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: January 15, 2008
Last modified: October 29, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3