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A9A8Q0 (TF2B_METM6) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcription initiation factor IIB

Short name=TFIIB
Gene names
Name:tfb
Ordered Locus Names:MmarC6_0908
OrganismMethanococcus maripaludis (strain C6 / ATCC BAA-1332) [Complete proteome] [HAMAP]
Taxonomic identifier444158 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus

Protein attributes

Sequence length339 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB) By similarity. HAMAP-Rule MF_00383

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_00383

Sequence similarities

Belongs to the TFIIB family.

Contains 1 TFIIB-type zinc finger.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 339339Transcription initiation factor IIB HAMAP-Rule MF_00383
PRO_1000122400

Regions

Repeat156 – 239841 HAMAP-Rule MF_00383
Repeat250 – 331822 HAMAP-Rule MF_00383
Zinc finger39 – 7032TFIIB-type HAMAP-Rule MF_00383

Sites

Metal binding431Zinc By similarity
Metal binding461Zinc By similarity
Metal binding621Zinc By similarity
Metal binding651Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
A9A8Q0 [UniParc].

Last modified January 15, 2008. Version 1.
Checksum: C1A1C03435A5B95A

FASTA33938,227
        10         20         30         40         50         60 
MKVEAITKEE TKKPERKIKL AIAKPEDYSN KNVILEKEEE LICPVCGSKN IIKDYERAEI 

        70         80         90        100        110        120 
VCEMCGCVLQ QNLFDVGPEW RAFDHEQRVK RSRVGAPMTY TIHDKGLSTV IDWRNKDSYG 

       130        140        150        160        170        180 
KDISADKRAQ LYRLRKWQRR IRVSDASERN LAFALSELDR IASKLGLPRN VRENAAVLYR 

       190        200        210        220        230        240 
GAVEKGLIRG RSIEGVAAAA LYAACRRCKV PRTLDEIAEV SRVDRKEIGR TYRFISRELN 

       250        260        270        280        290        300 
IRLAPTNPVD YVPRFASELK LPGEVESKAI SILQKAGEKG LTSGRGPTGV AAAAIYIASV 

       310        320        330 
LQGTRRTQRE VADVAGVTEV TIRNRYKELT EHLDIDVTL 

« Hide

References

[1]"Complete sequence of Methanococcus maripaludis C6."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Sieprawska-Lupa M., Whitman W.B., Richardson P.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C6 / ATCC BAA-1332.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000867 Genomic DNA. Translation: ABX01723.1.
RefSeqYP_001548955.1. NC_009975.1.

3D structure databases

ProteinModelPortalA9A8Q0.
SMRA9A8Q0. Positions 143-339.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING444158.MmarC6_0908.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABX01723; ABX01723; MmarC6_0908.
GeneID5738226.
KEGGmmx:MmarC6_0908.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1405.
HOGENOMHOG000108633.
KOK03124.
OMAWRAFDHD.
ProtClustDBPRK00423.

Enzyme and pathway databases

BioCycMMAR444158:GHN2-926-MONOMER.

Family and domain databases

Gene3D1.10.472.10. 2 hits.
HAMAPMF_00383. TF2B_arch.
InterProIPR013763. Cyclin-like.
IPR000812. TFIIB.
IPR023484. TFIIB_arc.
IPR023486. TFIIB_CS.
IPR013150. TFIIB_cyclin.
IPR013137. Znf_TFIIB.
[Graphical view]
PANTHERPTHR11618. PTHR11618. 1 hit.
PfamPF08271. TF_Zn_Ribbon. 1 hit.
PF00382. TFIIB. 2 hits.
[Graphical view]
PRINTSPR00685. TIFACTORIIB.
SMARTSM00385. CYCLIN. 2 hits.
[Graphical view]
SUPFAMSSF47954. SSF47954. 2 hits.
PROSITEPS00782. TFIIB. 2 hits.
PS51134. ZF_TFIIB. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTF2B_METM6
AccessionPrimary (citable) accession number: A9A8Q0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: January 15, 2008
Last modified: February 19, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families