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Protein

Transcription initiation factor IIB

Gene

tfb

Organism
Methanococcus maripaludis (strain C6 / ATCC BAA-1332)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi43ZincUniRule annotation1
Metal bindingi46ZincUniRule annotation1
Metal bindingi62ZincUniRule annotation1
Metal bindingi65ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri39 – 70TFIIB-typeUniRule annotationAdd BLAST32

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor IIBUniRule annotation
Short name:
TFIIBUniRule annotation
Gene namesi
Name:tfbUniRule annotation
Ordered Locus Names:MmarC6_0908
OrganismiMethanococcus maripaludis (strain C6 / ATCC BAA-1332)
Taxonomic identifieri444158 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000000791 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001224001 – 339Transcription initiation factor IIBAdd BLAST339

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi444158.MmarC6_0908.

Structurei

3D structure databases

ProteinModelPortaliA9A8Q0.
SMRiA9A8Q0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati156 – 2391Add BLAST84
Repeati250 – 3312Add BLAST82

Sequence similaritiesi

Belongs to the TFIIB family.UniRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri39 – 70TFIIB-typeUniRule annotationAdd BLAST32

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiarCOG01981. Archaea.
COG1405. LUCA.
HOGENOMiHOG000108633.
KOiK03124.
OMAiWRAFDHD.
OrthoDBiPOG093Z07LX.

Family and domain databases

CDDicd00043. CYCLIN. 2 hits.
Gene3Di1.10.472.10. 2 hits.
HAMAPiMF_00383. TF2B_arch. 1 hit.
InterProiView protein in InterPro
IPR013763. Cyclin-like.
IPR036915. Cyclin-like_sf.
IPR000812. TFIIB.
IPR023484. TFIIB_arc.
IPR023486. TFIIB_CS.
IPR013150. TFIIB_cyclin.
IPR013137. Znf_TFIIB.
PANTHERiPTHR11618. PTHR11618. 1 hit.
PfamiView protein in Pfam
PF08271. TF_Zn_Ribbon. 1 hit.
PF00382. TFIIB. 2 hits.
PRINTSiPR00685. TIFACTORIIB.
SMARTiView protein in SMART
SM00385. CYCLIN. 2 hits.
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiView protein in PROSITE
PS00782. TFIIB. 2 hits.
PS51134. ZF_TFIIB. 1 hit.

Sequencei

Sequence statusi: Complete.

A9A8Q0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVEAITKEE TKKPERKIKL AIAKPEDYSN KNVILEKEEE LICPVCGSKN
60 70 80 90 100
IIKDYERAEI VCEMCGCVLQ QNLFDVGPEW RAFDHEQRVK RSRVGAPMTY
110 120 130 140 150
TIHDKGLSTV IDWRNKDSYG KDISADKRAQ LYRLRKWQRR IRVSDASERN
160 170 180 190 200
LAFALSELDR IASKLGLPRN VRENAAVLYR GAVEKGLIRG RSIEGVAAAA
210 220 230 240 250
LYAACRRCKV PRTLDEIAEV SRVDRKEIGR TYRFISRELN IRLAPTNPVD
260 270 280 290 300
YVPRFASELK LPGEVESKAI SILQKAGEKG LTSGRGPTGV AAAAIYIASV
310 320 330
LQGTRRTQRE VADVAGVTEV TIRNRYKELT EHLDIDVTL
Length:339
Mass (Da):38,227
Last modified:January 15, 2008 - v1
Checksum:iC1A1C03435A5B95A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000867 Genomic DNA. Translation: ABX01723.1.
RefSeqiWP_012193675.1. NC_009975.1.

Genome annotation databases

EnsemblBacteriaiABX01723; ABX01723; MmarC6_0908.
GeneIDi5738226.
KEGGimmx:MmarC6_0908.

Similar proteinsi

Entry informationi

Entry nameiTF2B_METM6
AccessioniPrimary (citable) accession number: A9A8Q0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: January 15, 2008
Last modified: October 25, 2017
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families