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A9A8Q0

- TF2B_METM6

UniProt

A9A8Q0 - TF2B_METM6

Protein

Transcription initiation factor IIB

Gene

tfb

Organism
Methanococcus maripaludis (strain C6 / ATCC BAA-1332)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (15 Jan 2008)
      Previous versions | rss
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    • Comment

    Functioni

    Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi43 – 431ZincUniRule annotation
    Metal bindingi46 – 461ZincUniRule annotation
    Metal bindingi62 – 621ZincUniRule annotation
    Metal bindingi65 – 651ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri39 – 7032TFIIB-typeUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding transcription factor activity Source: UniProtKB-HAMAP
    2. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA-templated transcription, initiation Source: UniProtKB-HAMAP

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciMMAR444158:GHN2-926-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription initiation factor IIBUniRule annotation
    Short name:
    TFIIBUniRule annotation
    Gene namesi
    Name:tfbUniRule annotation
    Ordered Locus Names:MmarC6_0908
    OrganismiMethanococcus maripaludis (strain C6 / ATCC BAA-1332)
    Taxonomic identifieri444158 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
    ProteomesiUP000000791: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 339339Transcription initiation factor IIBPRO_1000122400Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi444158.MmarC6_0908.

    Structurei

    3D structure databases

    ProteinModelPortaliA9A8Q0.
    SMRiA9A8Q0. Positions 143-339.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati156 – 239841Add
    BLAST
    Repeati250 – 331822Add
    BLAST

    Sequence similaritiesi

    Belongs to the TFIIB family.UniRule annotation
    Contains 1 TFIIB-type zinc finger.UniRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri39 – 7032TFIIB-typeUniRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG1405.
    HOGENOMiHOG000108633.
    KOiK03124.
    OMAiWRAFDHD.

    Family and domain databases

    Gene3Di1.10.472.10. 2 hits.
    HAMAPiMF_00383. TF2B_arch.
    InterProiIPR013763. Cyclin-like.
    IPR000812. TFIIB.
    IPR023484. TFIIB_arc.
    IPR023486. TFIIB_CS.
    IPR013150. TFIIB_cyclin.
    IPR013137. Znf_TFIIB.
    [Graphical view]
    PANTHERiPTHR11618. PTHR11618. 1 hit.
    PfamiPF08271. TF_Zn_Ribbon. 1 hit.
    PF00382. TFIIB. 2 hits.
    [Graphical view]
    PRINTSiPR00685. TIFACTORIIB.
    SMARTiSM00385. CYCLIN. 2 hits.
    [Graphical view]
    SUPFAMiSSF47954. SSF47954. 2 hits.
    PROSITEiPS00782. TFIIB. 2 hits.
    PS51134. ZF_TFIIB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A9A8Q0-1 [UniParc]FASTAAdd to Basket

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    MKVEAITKEE TKKPERKIKL AIAKPEDYSN KNVILEKEEE LICPVCGSKN    50
    IIKDYERAEI VCEMCGCVLQ QNLFDVGPEW RAFDHEQRVK RSRVGAPMTY 100
    TIHDKGLSTV IDWRNKDSYG KDISADKRAQ LYRLRKWQRR IRVSDASERN 150
    LAFALSELDR IASKLGLPRN VRENAAVLYR GAVEKGLIRG RSIEGVAAAA 200
    LYAACRRCKV PRTLDEIAEV SRVDRKEIGR TYRFISRELN IRLAPTNPVD 250
    YVPRFASELK LPGEVESKAI SILQKAGEKG LTSGRGPTGV AAAAIYIASV 300
    LQGTRRTQRE VADVAGVTEV TIRNRYKELT EHLDIDVTL 339
    Length:339
    Mass (Da):38,227
    Last modified:January 15, 2008 - v1
    Checksum:iC1A1C03435A5B95A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000867 Genomic DNA. Translation: ABX01723.1.
    RefSeqiWP_012193675.1. NC_009975.1.
    YP_001548955.1. NC_009975.1.

    Genome annotation databases

    EnsemblBacteriaiABX01723; ABX01723; MmarC6_0908.
    GeneIDi5738226.
    KEGGimmx:MmarC6_0908.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000867 Genomic DNA. Translation: ABX01723.1 .
    RefSeqi WP_012193675.1. NC_009975.1.
    YP_001548955.1. NC_009975.1.

    3D structure databases

    ProteinModelPortali A9A8Q0.
    SMRi A9A8Q0. Positions 143-339.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 444158.MmarC6_0908.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABX01723 ; ABX01723 ; MmarC6_0908 .
    GeneIDi 5738226.
    KEGGi mmx:MmarC6_0908.

    Phylogenomic databases

    eggNOGi COG1405.
    HOGENOMi HOG000108633.
    KOi K03124.
    OMAi WRAFDHD.

    Enzyme and pathway databases

    BioCyci MMAR444158:GHN2-926-MONOMER.

    Family and domain databases

    Gene3Di 1.10.472.10. 2 hits.
    HAMAPi MF_00383. TF2B_arch.
    InterProi IPR013763. Cyclin-like.
    IPR000812. TFIIB.
    IPR023484. TFIIB_arc.
    IPR023486. TFIIB_CS.
    IPR013150. TFIIB_cyclin.
    IPR013137. Znf_TFIIB.
    [Graphical view ]
    PANTHERi PTHR11618. PTHR11618. 1 hit.
    Pfami PF08271. TF_Zn_Ribbon. 1 hit.
    PF00382. TFIIB. 2 hits.
    [Graphical view ]
    PRINTSi PR00685. TIFACTORIIB.
    SMARTi SM00385. CYCLIN. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47954. SSF47954. 2 hits.
    PROSITEi PS00782. TFIIB. 2 hits.
    PS51134. ZF_TFIIB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C6 / ATCC BAA-1332.

    Entry informationi

    Entry nameiTF2B_METM6
    AccessioniPrimary (citable) accession number: A9A8Q0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3