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A9A813

- IF2P_METM6

UniProt

A9A813 - IF2P_METM6

Protein

Probable translation initiation factor IF-2

Gene

infB

Organism
Methanococcus maripaludis (strain C6 / ATCC BAA-1332)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi12 – 198GTPUniRule annotation
    Nucleotide bindingi76 – 805GTPUniRule annotation
    Nucleotide bindingi130 – 1334GTPUniRule annotation

    GO - Molecular functioni

    1. GTPase activity Source: UniProtKB-HAMAP
    2. GTP binding Source: UniProtKB-KW
    3. translation initiation factor activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Initiation factor

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMMAR444158:GHN2-677-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable translation initiation factor IF-2UniRule annotation
    Gene namesi
    Name:infBUniRule annotation
    Ordered Locus Names:MmarC6_0669
    OrganismiMethanococcus maripaludis (strain C6 / ATCC BAA-1332)
    Taxonomic identifieri444158 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
    ProteomesiUP000000791: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 598598Probable translation initiation factor IF-2PRO_1000093802Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi444158.MmarC6_0669.

    Structurei

    3D structure databases

    ProteinModelPortaliA9A813.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini3 – 225223tr-type GAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni12 – 198G1By similarity
    Regioni37 – 415G2By similarity
    Regioni76 – 794G3By similarity
    Regioni130 – 1334G4By similarity
    Regioni200 – 2023G5By similarity

    Sequence similaritiesi

    Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0532.
    HOGENOMiHOG000105770.
    KOiK03243.
    OMAiIVCVMGH.

    Family and domain databases

    Gene3Di3.40.50.10050. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPiMF_00100_A. IF_2_A.
    InterProiIPR000795. EF_GTP-bd_dom.
    IPR029459. EFTU-type.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR004544. TIF_aIF-2_arc.
    IPR023115. TIF_IF2_dom3.
    IPR009000. Transl_B-barrel.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view]
    PfamiPF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    PF14578. GTP_EFTU_D4. 1 hit.
    PF11987. IF-2. 1 hit.
    [Graphical view]
    PRINTSiPR00315. ELONGATNFCT.
    SUPFAMiSSF50447. SSF50447. 1 hit.
    SSF52156. SSF52156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00491. aIF-2. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEiPS51722. G_TR_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A9A813-1 [UniParc]FASTAAdd to Basket

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    MALRCPIVSV LGHVDHGKTS LLDKIRSTRV TQREAGGITQ HIGASEIPIN    50
    TIKKVSKDLL GLFKADLTIP GLLVIDTPGH EAFTSLRKRG GALADIAILV 100
    VDMNEGFKPQ TIEAINILKQ CKTPFIVAAN KLDRVPGWNS KEGPFILNFN 150
    EKNQHPNAMT EFEIRLYENV IKHLNELGFD ADLFSRVKDT TKTINVVPVS 200
    AMTGEGIPDL LVIISGLAQK FLEQKLALNV EGYAKGTVLE LKEEKGLGKT 250
    IDAIIYDGIA KTGDFLVVGN PQGVLVSKIK ALLKPKELDE MRDPKDKFKP 300
    SKQISAATGV KISAPDLDNV IAGSPLRIVP KDQIENAKAE VLQEVEEFTI 350
    LTDDEGIIIK ADTMGSLEAL ANELRKVKAK IKKAEVGDIS KKDVIEASSY 400
    ASTNPLNGLI ISFNTKVLSD AKAEIEKSDV KLLEGRIIYK LVEEYEEWVK 450
    EMEELMKSDE INRLTKPAMI KILPNCIFRQ KEPAVCGVEV LYGTLKIGSP 500
    LMSEDGKKLG YVKEIRDNQQ ENIKEAKVGM QVPVSIDGNI VLGRNAKEND 550
    ILYVEVPEPE ARKLHHEFRD ELRGDEKEAL SRYMELKQKI ENNIFWGM 598
    Length:598
    Mass (Da):66,289
    Last modified:January 15, 2008 - v1
    Checksum:iA848923E8956D0D7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000867 Genomic DNA. Translation: ABX01486.1.
    RefSeqiWP_012193384.1. NC_009975.1.
    YP_001548718.1. NC_009975.1.

    Genome annotation databases

    EnsemblBacteriaiABX01486; ABX01486; MmarC6_0669.
    GeneIDi5738967.
    KEGGimmx:MmarC6_0669.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000867 Genomic DNA. Translation: ABX01486.1 .
    RefSeqi WP_012193384.1. NC_009975.1.
    YP_001548718.1. NC_009975.1.

    3D structure databases

    ProteinModelPortali A9A813.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 444158.MmarC6_0669.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABX01486 ; ABX01486 ; MmarC6_0669 .
    GeneIDi 5738967.
    KEGGi mmx:MmarC6_0669.

    Phylogenomic databases

    eggNOGi COG0532.
    HOGENOMi HOG000105770.
    KOi K03243.
    OMAi IVCVMGH.

    Enzyme and pathway databases

    BioCyci MMAR444158:GHN2-677-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.10050. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPi MF_00100_A. IF_2_A.
    InterProi IPR000795. EF_GTP-bd_dom.
    IPR029459. EFTU-type.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR004544. TIF_aIF-2_arc.
    IPR023115. TIF_IF2_dom3.
    IPR009000. Transl_B-barrel.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view ]
    Pfami PF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    PF14578. GTP_EFTU_D4. 1 hit.
    PF11987. IF-2. 1 hit.
    [Graphical view ]
    PRINTSi PR00315. ELONGATNFCT.
    SUPFAMi SSF50447. SSF50447. 1 hit.
    SSF52156. SSF52156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00491. aIF-2. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51722. G_TR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C6 / ATCC BAA-1332.

    Entry informationi

    Entry nameiIF2P_METM6
    AccessioniPrimary (citable) accession number: A9A813
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3