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Protein

Probable translation initiation factor IF-2

Gene

infB

Organism
Methanococcus maripaludis (strain C6 / ATCC BAA-1332)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 19GTPUniRule annotation8
Nucleotide bindingi76 – 80GTPUniRule annotation5
Nucleotide bindingi130 – 133GTPUniRule annotation4

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable translation initiation factor IF-2UniRule annotation
Gene namesi
Name:infBUniRule annotation
Ordered Locus Names:MmarC6_0669
OrganismiMethanococcus maripaludis (strain C6 / ATCC BAA-1332)
Taxonomic identifieri444158 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000000791 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000938021 – 598Probable translation initiation factor IF-2Add BLAST598

Interactioni

Protein-protein interaction databases

STRINGi444158.MmarC6_0669.

Structurei

3D structure databases

ProteinModelPortaliA9A813.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 225tr-type GAdd BLAST223

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni12 – 19G1By similarity8
Regioni37 – 41G2By similarity5
Regioni76 – 79G3By similarity4
Regioni130 – 133G4By similarity4
Regioni200 – 202G5By similarity3

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01560. Archaea.
COG0532. LUCA.
HOGENOMiHOG000105770.
KOiK03243.
OMAiLSQRYMK.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_A. IF_2_A. 1 hit.
InterProiIPR029459. EFTU-type.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR004544. TIF_aIF-2_arc.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
[Graphical view]
PfamiPF14578. GTP_EFTU_D4. 1 hit.
PF11987. IF-2. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00491. aIF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9A813-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRCPIVSV LGHVDHGKTS LLDKIRSTRV TQREAGGITQ HIGASEIPIN
60 70 80 90 100
TIKKVSKDLL GLFKADLTIP GLLVIDTPGH EAFTSLRKRG GALADIAILV
110 120 130 140 150
VDMNEGFKPQ TIEAINILKQ CKTPFIVAAN KLDRVPGWNS KEGPFILNFN
160 170 180 190 200
EKNQHPNAMT EFEIRLYENV IKHLNELGFD ADLFSRVKDT TKTINVVPVS
210 220 230 240 250
AMTGEGIPDL LVIISGLAQK FLEQKLALNV EGYAKGTVLE LKEEKGLGKT
260 270 280 290 300
IDAIIYDGIA KTGDFLVVGN PQGVLVSKIK ALLKPKELDE MRDPKDKFKP
310 320 330 340 350
SKQISAATGV KISAPDLDNV IAGSPLRIVP KDQIENAKAE VLQEVEEFTI
360 370 380 390 400
LTDDEGIIIK ADTMGSLEAL ANELRKVKAK IKKAEVGDIS KKDVIEASSY
410 420 430 440 450
ASTNPLNGLI ISFNTKVLSD AKAEIEKSDV KLLEGRIIYK LVEEYEEWVK
460 470 480 490 500
EMEELMKSDE INRLTKPAMI KILPNCIFRQ KEPAVCGVEV LYGTLKIGSP
510 520 530 540 550
LMSEDGKKLG YVKEIRDNQQ ENIKEAKVGM QVPVSIDGNI VLGRNAKEND
560 570 580 590
ILYVEVPEPE ARKLHHEFRD ELRGDEKEAL SRYMELKQKI ENNIFWGM
Length:598
Mass (Da):66,289
Last modified:January 15, 2008 - v1
Checksum:iA848923E8956D0D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000867 Genomic DNA. Translation: ABX01486.1.
RefSeqiWP_012193384.1. NC_009975.1.

Genome annotation databases

EnsemblBacteriaiABX01486; ABX01486; MmarC6_0669.
GeneIDi5738967.
KEGGimmx:MmarC6_0669.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000867 Genomic DNA. Translation: ABX01486.1.
RefSeqiWP_012193384.1. NC_009975.1.

3D structure databases

ProteinModelPortaliA9A813.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi444158.MmarC6_0669.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABX01486; ABX01486; MmarC6_0669.
GeneIDi5738967.
KEGGimmx:MmarC6_0669.

Phylogenomic databases

eggNOGiarCOG01560. Archaea.
COG0532. LUCA.
HOGENOMiHOG000105770.
KOiK03243.
OMAiLSQRYMK.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_A. IF_2_A. 1 hit.
InterProiIPR029459. EFTU-type.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR004544. TIF_aIF-2_arc.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
[Graphical view]
PfamiPF14578. GTP_EFTU_D4. 1 hit.
PF11987. IF-2. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00491. aIF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIF2P_METM6
AccessioniPrimary (citable) accession number: A9A813
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: January 15, 2008
Last modified: November 2, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.