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A9A813

- IF2P_METM6

UniProt

A9A813 - IF2P_METM6

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Protein

Probable translation initiation factor IF-2

Gene

infB

Organism
Methanococcus maripaludis (strain C6 / ATCC BAA-1332)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 198GTPUniRule annotation
Nucleotide bindingi76 – 805GTPUniRule annotation
Nucleotide bindingi130 – 1334GTPUniRule annotation

GO - Molecular functioni

  1. GTPase activity Source: UniProtKB-HAMAP
  2. GTP binding Source: UniProtKB-KW
  3. translation initiation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMMAR444158:GHN2-677-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable translation initiation factor IF-2UniRule annotation
Gene namesi
Name:infBUniRule annotation
Ordered Locus Names:MmarC6_0669
OrganismiMethanococcus maripaludis (strain C6 / ATCC BAA-1332)
Taxonomic identifieri444158 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
ProteomesiUP000000791: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 598598Probable translation initiation factor IF-2PRO_1000093802Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi444158.MmarC6_0669.

Structurei

3D structure databases

ProteinModelPortaliA9A813.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 225223tr-type GAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni12 – 198G1By similarity
Regioni37 – 415G2By similarity
Regioni76 – 794G3By similarity
Regioni130 – 1334G4By similarity
Regioni200 – 2023G5By similarity

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0532.
HOGENOMiHOG000105770.
KOiK03243.
OMAiIVCVMGH.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_A. IF_2_A.
InterProiIPR000795. EF_GTP-bd_dom.
IPR029459. EFTU-type.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR004544. TIF_aIF-2_arc.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF14578. GTP_EFTU_D4. 1 hit.
PF11987. IF-2. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00491. aIF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9A813-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALRCPIVSV LGHVDHGKTS LLDKIRSTRV TQREAGGITQ HIGASEIPIN
60 70 80 90 100
TIKKVSKDLL GLFKADLTIP GLLVIDTPGH EAFTSLRKRG GALADIAILV
110 120 130 140 150
VDMNEGFKPQ TIEAINILKQ CKTPFIVAAN KLDRVPGWNS KEGPFILNFN
160 170 180 190 200
EKNQHPNAMT EFEIRLYENV IKHLNELGFD ADLFSRVKDT TKTINVVPVS
210 220 230 240 250
AMTGEGIPDL LVIISGLAQK FLEQKLALNV EGYAKGTVLE LKEEKGLGKT
260 270 280 290 300
IDAIIYDGIA KTGDFLVVGN PQGVLVSKIK ALLKPKELDE MRDPKDKFKP
310 320 330 340 350
SKQISAATGV KISAPDLDNV IAGSPLRIVP KDQIENAKAE VLQEVEEFTI
360 370 380 390 400
LTDDEGIIIK ADTMGSLEAL ANELRKVKAK IKKAEVGDIS KKDVIEASSY
410 420 430 440 450
ASTNPLNGLI ISFNTKVLSD AKAEIEKSDV KLLEGRIIYK LVEEYEEWVK
460 470 480 490 500
EMEELMKSDE INRLTKPAMI KILPNCIFRQ KEPAVCGVEV LYGTLKIGSP
510 520 530 540 550
LMSEDGKKLG YVKEIRDNQQ ENIKEAKVGM QVPVSIDGNI VLGRNAKEND
560 570 580 590
ILYVEVPEPE ARKLHHEFRD ELRGDEKEAL SRYMELKQKI ENNIFWGM
Length:598
Mass (Da):66,289
Last modified:January 15, 2008 - v1
Checksum:iA848923E8956D0D7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000867 Genomic DNA. Translation: ABX01486.1.
RefSeqiYP_001548718.1. NC_009975.1.

Genome annotation databases

EnsemblBacteriaiABX01486; ABX01486; MmarC6_0669.
GeneIDi5738967.
KEGGimmx:MmarC6_0669.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000867 Genomic DNA. Translation: ABX01486.1 .
RefSeqi YP_001548718.1. NC_009975.1.

3D structure databases

ProteinModelPortali A9A813.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 444158.MmarC6_0669.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX01486 ; ABX01486 ; MmarC6_0669 .
GeneIDi 5738967.
KEGGi mmx:MmarC6_0669.

Phylogenomic databases

eggNOGi COG0532.
HOGENOMi HOG000105770.
KOi K03243.
OMAi IVCVMGH.

Enzyme and pathway databases

BioCyci MMAR444158:GHN2-677-MONOMER.

Family and domain databases

Gene3Di 3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_00100_A. IF_2_A.
InterProi IPR000795. EF_GTP-bd_dom.
IPR029459. EFTU-type.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR004544. TIF_aIF-2_arc.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view ]
Pfami PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF14578. GTP_EFTU_D4. 1 hit.
PF11987. IF-2. 1 hit.
[Graphical view ]
PRINTSi PR00315. ELONGATNFCT.
SUPFAMi SSF50447. SSF50447. 1 hit.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00491. aIF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEi PS51722. G_TR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C6 / ATCC BAA-1332.

Entry informationi

Entry nameiIF2P_METM6
AccessioniPrimary (citable) accession number: A9A813
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: January 15, 2008
Last modified: October 29, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3