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A9A813 (IF2P_METM6) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable translation initiation factor IF-2
Gene names
Name:infB
Ordered Locus Names:MmarC6_0669
OrganismMethanococcus maripaludis (strain C6 / ATCC BAA-1332) [Complete proteome] [HAMAP]
Taxonomic identifier444158 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus

Protein attributes

Sequence length598 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 By similarity. HAMAP-Rule MF_00100

Sequence similarities

Belongs to the IF-2 family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   LigandGTP-binding
Nucleotide-binding
   Molecular functionInitiation factor
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentintracellular

Inferred from electronic annotation. Source: InterPro

   Molecular_functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-KW

GTPase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

translation initiation factor activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 598598Probable translation initiation factor IF-2 HAMAP-Rule MF_00100
PRO_1000093802

Regions

Nucleotide binding12 – 198GTP By similarity
Nucleotide binding76 – 805GTP By similarity
Nucleotide binding130 – 1334GTP By similarity

Sequences

Sequence LengthMass (Da)Tools
A9A813 [UniParc].

Last modified January 15, 2008. Version 1.
Checksum: A848923E8956D0D7

FASTA59866,289
        10         20         30         40         50         60 
MALRCPIVSV LGHVDHGKTS LLDKIRSTRV TQREAGGITQ HIGASEIPIN TIKKVSKDLL 

        70         80         90        100        110        120 
GLFKADLTIP GLLVIDTPGH EAFTSLRKRG GALADIAILV VDMNEGFKPQ TIEAINILKQ 

       130        140        150        160        170        180 
CKTPFIVAAN KLDRVPGWNS KEGPFILNFN EKNQHPNAMT EFEIRLYENV IKHLNELGFD 

       190        200        210        220        230        240 
ADLFSRVKDT TKTINVVPVS AMTGEGIPDL LVIISGLAQK FLEQKLALNV EGYAKGTVLE 

       250        260        270        280        290        300 
LKEEKGLGKT IDAIIYDGIA KTGDFLVVGN PQGVLVSKIK ALLKPKELDE MRDPKDKFKP 

       310        320        330        340        350        360 
SKQISAATGV KISAPDLDNV IAGSPLRIVP KDQIENAKAE VLQEVEEFTI LTDDEGIIIK 

       370        380        390        400        410        420 
ADTMGSLEAL ANELRKVKAK IKKAEVGDIS KKDVIEASSY ASTNPLNGLI ISFNTKVLSD 

       430        440        450        460        470        480 
AKAEIEKSDV KLLEGRIIYK LVEEYEEWVK EMEELMKSDE INRLTKPAMI KILPNCIFRQ 

       490        500        510        520        530        540 
KEPAVCGVEV LYGTLKIGSP LMSEDGKKLG YVKEIRDNQQ ENIKEAKVGM QVPVSIDGNI 

       550        560        570        580        590 
VLGRNAKEND ILYVEVPEPE ARKLHHEFRD ELRGDEKEAL SRYMELKQKI ENNIFWGM 

« Hide

References

[1]"Complete sequence of Methanococcus maripaludis C6."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Sieprawska-Lupa M., Whitman W.B., Richardson P.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C6 / ATCC BAA-1332.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000867 Genomic DNA. Translation: ABX01486.1.
RefSeqYP_001548718.1. NC_009975.1.

3D structure databases

ProteinModelPortalA9A813.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING444158.MmarC6_0669.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABX01486; ABX01486; MmarC6_0669.
GeneID5738967.
KEGGmmx:MmarC6_0669.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0532.
HOGENOMHOG000105770.
KOK03243.
OMAIVCVMGH.
ProtClustDBPRK04004.

Enzyme and pathway databases

BioCycMMAR444158:GHN2-677-MONOMER.

Family and domain databases

Gene3D3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPMF_00100_A. IF_2_A.
InterProIPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR004544. TIF_aIF-2_arc.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF11987. IF-2. 1 hit.
[Graphical view]
PRINTSPR00315. ELONGATNFCT.
SUPFAMSSF50447. SSF50447. 1 hit.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00491. aIF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameIF2P_METM6
AccessionPrimary (citable) accession number: A9A813
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: January 15, 2008
Last modified: April 16, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Translation initiation factors

List of translation initiation factor entries