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A9A756 (HIS7_METM6) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Imidazoleglycerol-phosphate dehydratase

Short name=IGPD
EC=4.2.1.19
Gene names
Name:hisB
Ordered Locus Names:MmarC6_0344
OrganismMethanococcus maripaludis (strain C6 / ATCC BAA-1332) [Complete proteome] [HAMAP]
Taxonomic identifier444158 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus

Protein attributes

Sequence length190 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O. HAMAP-Rule MF_00076

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9. HAMAP-Rule MF_00076

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00076.

Sequence similarities

Belongs to the imidazoleglycerol-phosphate dehydratase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Histidine biosynthesis
   Cellular componentCytoplasm
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processhistidine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionimidazoleglycerol-phosphate dehydratase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 190190Imidazoleglycerol-phosphate dehydratase HAMAP-Rule MF_00076
PRO_1000092700

Sequences

Sequence LengthMass (Da)Tools
A9A756 [UniParc].

Last modified January 15, 2008. Version 1.
Checksum: 4D49570AB7596539

FASTA19021,088
        10         20         30         40         50         60 
MRAFKVTRDT NETKIHLELN IDGTGKYAIT TGIAFFDHVL SSFAKHGAFD LKLDVLGDLE 

        70         80         90        100        110        120 
IDDHHTVEDV GIVLGKAFEN MEKKNIKRFG WAIIPMDEAK ATVSIDIGGR PYVVGGYTPN 

       130        140        150        160        170        180 
TEKIGNFSTE NVVHFFESFS NNAKINLHFE VTGENEHHKV EALFKAFGVA MDMATQVDER 

       190 
KGIVSTKGVI 

« Hide

References

[1]"Complete sequence of Methanococcus maripaludis C6."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Sieprawska-Lupa M., Whitman W.B., Richardson P.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C6 / ATCC BAA-1332.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000867 Genomic DNA. Translation: ABX01165.1.
RefSeqYP_001548397.1. NC_009975.1.

3D structure databases

ProteinModelPortalA9A756.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING444158.MmarC6_0344.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABX01165; ABX01165; MmarC6_0344.
GeneID5739100.
KEGGmmx:MmarC6_0344.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0131.
HOGENOMHOG000228064.
KOK01693.
OMAIPMDEAK.
ProtClustDBPRK00951.

Enzyme and pathway databases

BioCycMMAR444158:GHN2-345-MONOMER.
UniPathwayUPA00031; UER00011.

Family and domain databases

HAMAPMF_00076. HisB.
InterProIPR000807. ImidazoleglycerolP_deHydtase.
IPR020565. ImidazoleglycerP_deHydtase_CS.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
PANTHERPTHR23133:SF2. PTHR23133:SF2. 1 hit.
PfamPF00475. IGPD. 1 hit.
[Graphical view]
SUPFAMSSF54211. SSF54211. 2 hits.
PROSITEPS00954. IGP_DEHYDRATASE_1. 1 hit.
PS00955. IGP_DEHYDRATASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHIS7_METM6
AccessionPrimary (citable) accession number: A9A756
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: January 15, 2008
Last modified: February 19, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways