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Protein

AMP phosphorylase

Gene

MmarC6_0624

Organism
Methanococcus maripaludis (strain C6 / ATCC BAA-1332)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.UniRule annotation

Catalytic activityi

AMP + phosphate = adenine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
CMP + phosphate = cytosine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
UMP + phosphate = uracil + alpha-D-ribose 1,5-bisphosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei170AMP; via amide nitrogenUniRule annotation1
Binding sitei205AMP; via amide nitrogenUniRule annotation1
Active sitei258Proton donorUniRule annotation1
Binding sitei266AMPUniRule annotation1
Binding sitei290AMPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi196 – 201AMPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciMMAR444158:G1GAE-627-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
AMP phosphorylaseUniRule annotation (EC:2.4.2.57UniRule annotation)
Short name:
AMPpaseUniRule annotation
Alternative name(s):
Nucleoside monophosphate phosphorylaseUniRule annotation
Short name:
NMP phosphorylaseUniRule annotation
Gene namesi
Ordered Locus Names:MmarC6_0624
OrganismiMethanococcus maripaludis (strain C6 / ATCC BAA-1332)
Taxonomic identifieri444158 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000000791 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001323521 – 505AMP phosphorylaseAdd BLAST505

Interactioni

Protein-protein interaction databases

STRINGi444158.MmarC6_0624

Structurei

3D structure databases

ProteinModelPortaliA9A6M7
SMRiA9A6M7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG02013 Archaea
COG0213 LUCA
HOGENOMiHOG000252767
KOiK18931
OMAiVHSIGGV
OrthoDBiPOG093Z01M3

Family and domain databases

Gene3Di3.40.1030.10, 1 hit
3.90.1170.30, 1 hit
HAMAPiMF_02132 AMP_phosphorylase, 1 hit
InterProiView protein in InterPro
IPR017713 AMP_phosphorylase
IPR000312 Glycosyl_Trfase_fam3
IPR017459 Glycosyl_Trfase_fam3_N_dom
IPR036320 Glycosyl_Trfase_fam3_N_dom)sf
IPR035902 Nuc_phospho_transferase
IPR036566 PYNP-like_C_sf
IPR013102 PYNP_C
IPR017872 Pyrmidine_PPase_CS
IPR013466 Thymidine/AMP_Pase
IPR000053 Thymidine/pyrmidine_PPase
PANTHERiPTHR10515 PTHR10515, 1 hit
PfamiView protein in Pfam
PF02885 Glycos_trans_3N, 1 hit
PF00591 Glycos_transf_3, 1 hit
PF07831 PYNP_C, 1 hit
PIRSFiPIRSF000478 TP_PyNP, 1 hit
SMARTiView protein in SMART
SM00941 PYNP_C, 1 hit
SUPFAMiSSF47648 SSF47648, 1 hit
SSF52418 SSF52418, 1 hit
SSF54680 SSF54680, 1 hit
TIGRFAMsiTIGR03327 AMP_phos, 1 hit
TIGR02645 ARCH_P_rylase, 1 hit
PROSITEiView protein in PROSITE
PS00647 THYMID_PHOSPHORYLASE, 1 hit

Sequencei

Sequence statusi: Complete.

A9A6M7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFLNAKFID LDLGENAVIV NDEDLKGTSY YPQDRVLIES HAGAVIGNIY
60 70 80 90 100
STKTMVKKGE VGMLVKELKE VSISEGEEVK LRHAEKPESI PFIKKKMDGQ
110 120 130 140 150
VLNPHEIRTI IDEIVSKKLS NIELSAFVSS TYINGMNMDE ISEMTKRIAE
160 170 180 190 200
TGDMISWEKS LVVDIHSIGG VPGNKYALLS IPILAAAGIT IPKTSSRAIT
210 220 230 240 250
SPAGTADVME VLTNVELKEE EIKRIVKTTN GCLAWGGGVN LAPADDIIIN
260 270 280 290 300
VERPVSIDPQ PQLLASVMAK KIATGIKYTV IDIPVGKGVK IKNEAEGAKL
310 320 330 340 350
ARKFIELGEL LNIKVECVLT YGGQPLGRAI GPALEAREAI EALQDPKNAP
360 370 380 390 400
KSLIEKALSL AGILLELGGA AQIGEGQKLA WEILESGRAL EKFNQIITEQ
410 420 430 440 450
GGTPKKPEEI ELGEYVEEII APIDGYITDI SNTAITNVVK EAGAPRDKKA
460 470 480 490 500
GILLNSKIGN QVKQGDILYT IYSGSEERLV SAVNLARRVY PVKVEGMLIE

RISKF
Length:505
Mass (Da):54,713
Last modified:January 15, 2008 - v1
Checksum:i2ADABA0720CE7C5C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000867 Genomic DNA Translation: ABX01441.1
RefSeqiWP_012193341.1, NC_009975.1

Genome annotation databases

EnsemblBacteriaiABX01441; ABX01441; MmarC6_0624
GeneIDi5738887
KEGGimmx:MmarC6_0624

Similar proteinsi

Entry informationi

Entry nameiAMPPA_METM6
AccessioniPrimary (citable) accession number: A9A6M7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: January 15, 2008
Last modified: March 28, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health