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A9A6M7 (AMPPA_METM6) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
AMP phosphorylase

Short name=AMPpase
EC=2.4.2.57
Alternative name(s):
Nucleoside monophosphate phosphorylase
Short name=NMP phosphorylase
Gene names
Ordered Locus Names:MmarC6_0624
OrganismMethanococcus maripaludis (strain C6 / ATCC BAA-1332) [Complete proteome] [HAMAP]
Taxonomic identifier444158 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus

Protein attributes

Sequence length505 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO By similarity. HAMAP-Rule MF_02132

Catalytic activity

AMP + phosphate = adenine + alpha-D-ribose 1,5-bisphosphate. HAMAP-Rule MF_02132

CMP + phosphate = cytosine + alpha-D-ribose 1,5-bisphosphate. HAMAP-Rule MF_02132

UMP + phosphate = uracil + alpha-D-ribose 1,5-bisphosphate. HAMAP-Rule MF_02132

Sequence similarities

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 505505AMP phosphorylase HAMAP-Rule MF_02132
PRO_1000132352

Regions

Nucleotide binding196 – 2016AMP By similarity

Sites

Active site2581Proton donor By similarity
Binding site1701AMP; via amide nitrogen By similarity
Binding site2051AMP; via amide nitrogen By similarity
Binding site2661AMP By similarity
Binding site2901AMP By similarity

Sequences

Sequence LengthMass (Da)Tools
A9A6M7 [UniParc].

Last modified January 15, 2008. Version 1.
Checksum: 2ADABA0720CE7C5C

FASTA50554,713
        10         20         30         40         50         60 
MLFLNAKFID LDLGENAVIV NDEDLKGTSY YPQDRVLIES HAGAVIGNIY STKTMVKKGE 

        70         80         90        100        110        120 
VGMLVKELKE VSISEGEEVK LRHAEKPESI PFIKKKMDGQ VLNPHEIRTI IDEIVSKKLS 

       130        140        150        160        170        180 
NIELSAFVSS TYINGMNMDE ISEMTKRIAE TGDMISWEKS LVVDIHSIGG VPGNKYALLS 

       190        200        210        220        230        240 
IPILAAAGIT IPKTSSRAIT SPAGTADVME VLTNVELKEE EIKRIVKTTN GCLAWGGGVN 

       250        260        270        280        290        300 
LAPADDIIIN VERPVSIDPQ PQLLASVMAK KIATGIKYTV IDIPVGKGVK IKNEAEGAKL 

       310        320        330        340        350        360 
ARKFIELGEL LNIKVECVLT YGGQPLGRAI GPALEAREAI EALQDPKNAP KSLIEKALSL 

       370        380        390        400        410        420 
AGILLELGGA AQIGEGQKLA WEILESGRAL EKFNQIITEQ GGTPKKPEEI ELGEYVEEII 

       430        440        450        460        470        480 
APIDGYITDI SNTAITNVVK EAGAPRDKKA GILLNSKIGN QVKQGDILYT IYSGSEERLV 

       490        500 
SAVNLARRVY PVKVEGMLIE RISKF 

« Hide

References

[1]"Complete sequence of Methanococcus maripaludis C6."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Sieprawska-Lupa M., Whitman W.B., Richardson P.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C6 / ATCC BAA-1332.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000867 Genomic DNA. Translation: ABX01441.1.
RefSeqYP_001548673.1. NC_009975.1.

3D structure databases

ProteinModelPortalA9A6M7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING444158.MmarC6_0624.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABX01441; ABX01441; MmarC6_0624.
GeneID5738887.
KEGGmmx:MmarC6_0624.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0213.
HOGENOMHOG000252767.
KOK00758.
OMAFINGVRD.

Enzyme and pathway databases

BioCycMMAR444158:GHN2-632-MONOMER.

Family and domain databases

Gene3D3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
HAMAPMF_02132. AMP_phosphorylase.
InterProIPR017713. AMP_phosphorylase.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR013466. Thymidine/AMP_Pase.
[Graphical view]
PANTHERPTHR10515. PTHR10515. 1 hit.
PfamPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
PIRSFPIRSF000478. TP_PyNP. 1 hit.
SMARTSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsTIGR03327. AMP_phos. 1 hit.
TIGR02645. ARCH_P_rylase. 1 hit.
PROSITEPS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAMPPA_METM6
AccessionPrimary (citable) accession number: A9A6M7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: January 15, 2008
Last modified: May 14, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families