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A9A5Y7

- IMDH_NITMS

UniProt

A9A5Y7 - IMDH_NITMS

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Protein

Inosine-5'-monophosphate dehydrogenase

Gene
guaB, Nmar_1569
Organism
Nitrosopumilus maritimus (strain SCM1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth By similarity.UniRule annotation

Catalytic activityi

Inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH.UniRule annotation

Cofactori

Potassium By similarity.UniRule annotation

Enzyme regulationi

Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei244 – 2441NAD By similarity
Metal bindingi296 – 2961Potassium; via carbonyl oxygen By similarity
Metal bindingi298 – 2981Potassium; via carbonyl oxygen By similarity
Binding sitei299 – 2991IMP By similarity
Active sitei301 – 3011Thioimidate intermediate By similarity
Metal bindingi301 – 3011Potassium; via carbonyl oxygen By similarity
Binding sitei413 – 4131IMP By similarity
Metal bindingi467 – 4671Potassium; via carbonyl oxygen; shared with tetrameric partner By similarity
Metal bindingi468 – 4681Potassium; via carbonyl oxygen; shared with tetrameric partner By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi294 – 2963NAD By similarity

GO - Molecular functioni

  1. adenyl nucleotide binding Source: InterPro
  2. IMP dehydrogenase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. GMP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

GMP biosynthesis, Purine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Potassium

Enzyme and pathway databases

BioCyciNMAR436308:GI3J-1613-MONOMER.
UniPathwayiUPA00601; UER00295.

Names & Taxonomyi

Protein namesi
Recommended name:
Inosine-5'-monophosphate dehydrogenase (EC:1.1.1.205)
Short name:
IMP dehydrogenase
Short name:
IMPD
Short name:
IMPDH
Gene namesi
Name:guaB
Ordered Locus Names:Nmar_1569
OrganismiNitrosopumilus maritimus (strain SCM1)
Taxonomic identifieri436308 [NCBI]
Taxonomic lineageiArchaeaThaumarchaeotaNitrosopumilalesNitrosopumilaceaeNitrosopumilus
ProteomesiUP000000792: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 476476Inosine-5'-monophosphate dehydrogenaseUniRule annotationPRO_0000415694Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi436308.Nmar_1569.

Structurei

3D structure databases

ProteinModelPortaliA9A5Y7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini92 – 15059CBS 1Add
BLAST
Domaini151 – 20757CBS 2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni334 – 3363IMP binding By similarity
Regioni357 – 3582IMP binding By similarity
Regioni381 – 3855IMP binding By similarity

Sequence similaritiesi

Belongs to the IMPDH/GMPR family.
Contains 2 CBS domains.

Keywords - Domaini

CBS domain, Repeat

Phylogenomic databases

eggNOGiCOG0517.
HOGENOMiHOG000165755.
KOiK00088.
OMAiHGHSKNI.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01964. IMPDH.
InterProiIPR013785. Aldolase_TIM.
IPR000644. CBS_dom.
IPR005990. IMP_DH.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view]
PfamiPF00571. CBS. 2 hits.
PF00478. IMPDH. 1 hit.
[Graphical view]
PIRSFiPIRSF000130. IMPDH. 1 hit.
SMARTiSM00116. CBS. 2 hits.
[Graphical view]
TIGRFAMsiTIGR01302. IMP_dehydrog. 1 hit.
PROSITEiPS51371. CBS. 2 hits.
PS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9A5Y7-1 [UniParc]FASTAAdd to Basket

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MEFKEGLTFD DVLLVPKYSD ITSRSQTDLT TKLSRNITIN IPFVSANMDT    50
VTESSMAVAM ARAGGIGIIH RFLTIQEQAN EVLKVKRSGS VMIENPYSIS 100
SDKSIQDALD YAEDKEISGL LVVDSNSKLV GIVTERDLLF AGSNGTIADV 150
MTKDVVTAKP GVSLDEAKDI LHKHRIEKLP IVDDSGIIQG LITSKDITNN 200
TDYPNASKDK KGRPLVGAAV GVKGDFLERS ESLLNAGADV LVVDIAHGHS 250
ENAISTVRNI KKAFPDCELI AGNIATAQGA EDLIKAGVDA VKVGVGSGSI 300
CITRVITGSG VPQLTAVMDC AKIGNDHGIP IISDGGTRTS GDATKALAAG 350
ASSVMVGSML GGTDESPGTV LTKNGKRFKV YRGMASLAAS IGRKSKETGS 400
ISLEDDLNDY VAEGVEAMVP YKGTVTDILK QLAGGVRSGL SYCGAHTIPQ 450
MQQNAEFIKM SRAGFAESQP HDVLLM 476
Length:476
Mass (Da):50,130
Last modified:January 15, 2008 - v1
Checksum:i19BE67B0C7883900
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000866 Genomic DNA. Translation: ABX13465.1.
RefSeqiYP_001582903.1. NC_010085.1.

Genome annotation databases

EnsemblBacteriaiABX13465; ABX13465; Nmar_1569.
GeneIDi5772999.
KEGGinmr:Nmar_1569.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000866 Genomic DNA. Translation: ABX13465.1 .
RefSeqi YP_001582903.1. NC_010085.1.

3D structure databases

ProteinModelPortali A9A5Y7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 436308.Nmar_1569.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX13465 ; ABX13465 ; Nmar_1569 .
GeneIDi 5772999.
KEGGi nmr:Nmar_1569.

Phylogenomic databases

eggNOGi COG0517.
HOGENOMi HOG000165755.
KOi K00088.
OMAi HGHSKNI.

Enzyme and pathway databases

UniPathwayi UPA00601 ; UER00295 .
BioCyci NMAR436308:GI3J-1613-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01964. IMPDH.
InterProi IPR013785. Aldolase_TIM.
IPR000644. CBS_dom.
IPR005990. IMP_DH.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view ]
Pfami PF00571. CBS. 2 hits.
PF00478. IMPDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF000130. IMPDH. 1 hit.
SMARTi SM00116. CBS. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR01302. IMP_dehydrog. 1 hit.
PROSITEi PS51371. CBS. 2 hits.
PS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SCM1.

Entry informationi

Entry nameiIMDH_NITMS
AccessioniPrimary (citable) accession number: A9A5Y7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: January 15, 2008
Last modified: June 11, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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