A9A5X1 (HIS4_NITMS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
EC=5.3.1.16

Alternative name(s):
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Gene names

Name:	hisA
Ordered Locus Names:	Nmar_1553

Organism

Nitrosopumilus maritimus (strain SCM1) [Reference proteome] [HAMAP]

Taxonomic identifier

436308 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Thaumarchaeota › Nitrosopumilales › Nitrosopumilaceae › Nitrosopumilus › Nitrosopumilus maritimus

Protein attributes

Sequence length	236 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxyribulos-1-ylamino)methylideneamino)-1-(5-phosphoribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_01014
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9. HAMAP-Rule MF_01014
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the HisA/HisF family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 236	236	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase HAMAP-Rule MF_01014		PRO_1000135133
Sites
	Active site	8	1	Proton acceptor By similarity
	Active site	128	1	Proton donor By similarity

Sequences

	Sequence		Length	Mass (Da)
	A9A5X1 [UniParc]. Last modified January 15, 2008. Version 1. Checksum: EEAC72DBB0D0274A	FASTA	236	25,960
	10 20 30 40 50 60 MKIIPAIDLM DGQVVRLYKG DPKQKTVYSD DPVSVAKKWQ KAGADMLHIV DLDATIGTGS 70 80 90 100 110 120 NLDLIEKISK ELSIPVEVAG GLRNEEIIDR AISFSNRVVI GTMAFKDKEM LQRIAKKYDF 130 140 150 160 170 180 SKIVISVDHI DGFIVTHGWQ ESTKTPLLDA INEFVSMGFT EFLLTNVSKD GTLEGPDLEY 190 200 210 220 230 LEKACAVQNA NVIASGGISN IDDVSDVQRK NAFAVILGKA LYENKISIEE AKQLVN

References

[1]

"Complete sequence of Nitrosopumilus maritimus SCM1." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Stahl D., Richardson P. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SCM1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000866 Genomic DNA. Translation: ABX13449.1.
RefSeq	YP_001582887.1. NC_010085.1.
3D structure databases
ProteinModelPortal	A9A5X1.
ModBase	Search...
Protein-protein interaction databases
STRING	436308.Nmar_1553.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABX13449; ABX13449; Nmar_1553.
GeneID	5774221.
KEGG	nmr:Nmar_1553.
Phylogenomic databases
eggNOG	COG0106.
HOGENOM	HOG000224614.
KO	K01814.
OMA	DGHCVRL.
Enzyme and pathway databases
BioCyc	NMAR436308:GI3J-1590-MONOMER.
UniPathway	UPA00031; UER00009.
Family and domain databases
Gene3D	3.20.20.70. 1 hit.
HAMAP	MF_01014. HisA.
InterPro	IPR013785. Aldolase_TIM. IPR006062. His_biosynth. IPR006063. HisA. IPR023016. Isoase_HisA. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Pfam	PF00977. His_biosynth. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
TIGRFAMs	TIGR00007. TIGR00007. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HIS4_NITMS

Accession

Primary (citable) accession number: A9A5X1

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	January 15, 2008
Last modified:	May 1, 2013
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program