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A9A5G5 (A9A5G5_NITMS) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoribosylformylglycinamidine synthase 2 HAMAP MF_00420
EC=6.3.5.3 HAMAP MF_00420
Alternative name(s):
Phosphoribosylformylglycinamidine synthase II HAMAP MF_00420
Gene names
Name:purL HAMAP MF_00420
Ordered Locus Names:Nmar_0780
OrganismNitrosopumilus maritimus (strain SCM1)
Taxonomic identifier436308 [NCBI]
Taxonomic lineageArchaea › Thaumarchaeota › marine archaeal group 1 › Nitrosopumilales › Nitrosopumilaceae › Nitrosopumilus

Protein attributes

Sequence length721 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate. HAMAP MF_00420

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2. HAMAP MF_00420

Subunit structure

Heterodimer of two subunits, PurQ and PurL By similarity. HAMAP MF_00420

Subcellular location

Cytoplasm By similarity HAMAP MF_00420.

Sequence similarities

Belongs to the FGAMS family. HAMAP MF_00420

Sequences

Sequence LengthMass (Da)Tools
A9A5G5 [UniParc].

Last modified January 15, 2008. Version 1.
Checksum: 1FFD22644383AD18

FASTA72179,152
        10         20         30         40         50         60 
MSLEPQELTE LKSKIGREPT STELQIIAAE WSEHCSYKSS KRHLKMLPMK GPLVITEKGY 

        70         80         90        100        110        120 
DSGVLDVGDG YVVTAHIESH NHPSAVEPYG GAATGVGGVI RDILSAGTRP IAIFDGLRFG 

       130        140        150        160        170        180 
DIEKDQQARW LFKNAVTGIA DYGNCLGIPT IGGEVEFDKC YENYALVDVA AVGFGKKENL 

       190        200        210        220        230        240 
IKNHAKKGDI VVLMGGSTGR DGIGGSQFAS DSLESEDRSA VQIPDPFIEK LIIEAILEAR 

       250        260        270        280        290        300 
NDKLIHAMKD LGGGGLSCAI SETADALEIG IEMDVDKVHT RESGMHPDEI MVSESQERML 

       310        320        330        340        350        360 
IVTSKTKFKK LQAICKKFRI GCSVIGTVKS DNQMHVKKGK KTFANLPTDV VANATLLDLP 

       370        380        390        400        410        420 
SKEPTYLKTI EKEKKLKPIS DYSKTMMKLL SSPNIASKIW VYGQYDHEVG IRTVVKPGRD 

       430        440        450        460        470        480 
ASVLRLDNGK FLSVKIDGNP KQCYINPREG AIGCFEEACR NVVCTGAKPI GMLDHLQFGS 

       490        500        510        520        530        540 
PKDPEIFWTF LESLKGLTDF AKDFKIPCVG GKVSLYNETP DGPIKPTPLI GVLGLIDKTP 

       550        560        570        580        590        600 
QIPQRISKDD CLIIVGETKD ELGGSEYFEY IHKFIGGKCP AVDFTESKKN MKSVLEIIPK 

       610        620        630        640        650        660 
KLLKSVHDCS KGGLAVAVSE LSMNNQIGCK VDLDKVPAKK LDVDRILFSE SHSRYLLTFD 

       670        680        690        700        710        720 
KKNLSKVEKI LKKNKTSYNI IGQFGGEKIQ FTKGKKSIID LRVDKAQKTW LNSLKDLVLH 


G

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References

[1]"Complete sequence of Nitrosopumilus maritimus SCM1."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Stahl D., Richardson P.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SCM1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000866 Genomic DNA. Translation: ABX12676.1.
RefSeqYP_001582114.1. NC_010085.1.

3D structure databases

ProteinModelPortalA9A5G5.
ModBaseSearch...

Protein-protein interaction databases

STRINGA9A5G5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5774464.
GenomeReviewsGene locus Nmar_0780 in contig CP000866_GR.
KEGGnmr:Nmar_0780.

Phylogenomic databases

HOGENOMHBG311214.
OMAYGNSFGV.

Family and domain databases

HAMAPMF_00420. PurL_2.
[Tree]
InterProIPR000728. AIR_synth.
IPR010918. AIR_synth_C.
IPR010074. PRibForGlyAmidine_synth_II.
IPR016188. PurM_N-like.
[Graphical view]
KOK01952.
PfamPF00586. AIRS. 2 hits.
PF02769. AIRS_C. 2 hits.
[Graphical view]
SUPFAMSSF56042. AIR_synth_C. 2 hits.
SSF55326. PurM_N-like. 2 hits.
TIGRFAMsTIGR01736. FGAM_synth_II. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA9A5G5_NITMS
AccessionPrimary (citable) accession number: A9A5G5
Entry history
Integrated into UniProtKB/TrEMBL: January 15, 2008
Last sequence update: January 15, 2008
Last modified: January 25, 2012
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info