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A9A450

- MDH_NITMS

UniProt

A9A450 - MDH_NITMS

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Protein

Malate dehydrogenase

Gene

mdh

Organism
Nitrosopumilus maritimus (strain SCM1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei31 – 311NADUniRule annotation
Binding sitei80 – 801SubstrateUniRule annotation
Binding sitei86 – 861SubstrateUniRule annotation
Binding sitei93 – 931NADUniRule annotation
Binding sitei118 – 1181SubstrateUniRule annotation
Binding sitei149 – 1491SubstrateUniRule annotation
Active sitei173 – 1731Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi6 – 116NADUniRule annotation
Nucleotide bindingi116 – 1183NADUniRule annotation

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciNMAR436308:GI3J-353-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:Nmar_0338
OrganismiNitrosopumilus maritimus (strain SCM1)
Taxonomic identifieri436308 [NCBI]
Taxonomic lineageiArchaeaThaumarchaeotaNitrosopumilalesNitrosopumilaceaeNitrosopumilus
ProteomesiUP000000792: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 304304Malate dehydrogenasePRO_1000126142Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi436308.Nmar_0338.

Structurei

3D structure databases

ProteinModelPortaliA9A450.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000213794.
KOiK00024.
OMAiYGQNDIC.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.

Sequencei

Sequence statusi: Complete.

A9A450-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MITIIGSGKV GGDAALFSAL KRLDDQILLL DVAEGLPQGE AMDINHMLSE
60 70 80 90 100
QGIDVEVKGS NNFEDMKGSN IVVVVAGSGR KPGMTRMDLL KINASIVKSV
110 120 130 140 150
VENVKKYADD SMIIPVTNPL DPMAYITYKV SGFDRSRVFG MGGMLDLSRF
160 170 180 190 200
RQFIHEATGH SRDSIRALVI GEHGENMLPL PRFSSVSGIP LPSLLPKEKL
210 220 230 240 250
EELVQNTKQV AAKVIELKGA TVHAPGNAIS AIVEAVVRDR KQVIPVATYL
260 270 280 290 300
DGEYDHSDVT IGVPAVIGKN GVEKIIELDL NDEEKQVFNK AVENVKGALS

GVEI
Length:304
Mass (Da):32,783
Last modified:January 15, 2008 - v1
Checksum:iCCD4FA954CD3A944
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000866 Genomic DNA. Translation: ABX12234.1.
RefSeqiYP_001581672.1. NC_010085.1.

Genome annotation databases

EnsemblBacteriaiABX12234; ABX12234; Nmar_0338.
GeneIDi5773832.
KEGGinmr:Nmar_0338.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000866 Genomic DNA. Translation: ABX12234.1 .
RefSeqi YP_001581672.1. NC_010085.1.

3D structure databases

ProteinModelPortali A9A450.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 436308.Nmar_0338.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX12234 ; ABX12234 ; Nmar_0338 .
GeneIDi 5773832.
KEGGi nmr:Nmar_0338.

Phylogenomic databases

eggNOGi COG0039.
HOGENOMi HOG000213794.
KOi K00024.
OMAi YGQNDIC.

Enzyme and pathway databases

BioCyci NMAR436308:GI3J-353-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_00487. Malate_dehydrog_3.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
PRINTSi PR00086. LLDHDRGNASE.
SUPFAMi SSF56327. SSF56327. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SCM1.

Entry informationi

Entry nameiMDH_NITMS
AccessioniPrimary (citable) accession number: A9A450
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: January 15, 2008
Last modified: October 1, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3