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A9A423

- SYE_NITMS

UniProt

A9A423 - SYE_NITMS

Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Nitrosopumilus maritimus (strain SCM1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

    Catalytic activityi

    ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciNMAR436308:GI3J-325-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
    Alternative name(s):
    Glutamyl-tRNA synthetaseUniRule annotation
    Short name:
    GluRSUniRule annotation
    Gene namesi
    Name:gltXUniRule annotation
    Ordered Locus Names:Nmar_0311
    OrganismiNitrosopumilus maritimus (strain SCM1)
    Taxonomic identifieri436308 [NCBI]
    Taxonomic lineageiArchaeaThaumarchaeotaNitrosopumilalesNitrosopumilaceaeNitrosopumilus
    ProteomesiUP000000792: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 569569Glutamate--tRNA ligasePRO_0000367804Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi436308.Nmar_0311.

    Structurei

    3D structure databases

    ProteinModelPortaliA9A423.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi107 – 11711"HIGH" regionAdd
    BLAST

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0008.
    HOGENOMiHOG000073585.
    KOiK01885.
    OMAiYLGWDDP.

    Family and domain databases

    Gene3Di1.10.1160.10. 1 hit.
    2.40.240.10. 2 hits.
    3.40.50.620. 2 hits.
    HAMAPiMF_00022_A. Glu_tRNA_synth_A.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR004526. Glu-tRNA-synth_arc/euk.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
    IPR022888. Glu_tRNA_synth_arc.
    IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
    IPR011035. Ribosomal_L25/Gln-tRNA_synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR10119. PTHR10119. 1 hit.
    PfamiPF00749. tRNA-synt_1c. 1 hit.
    PF03950. tRNA-synt_1c_C. 1 hit.
    [Graphical view]
    PRINTSiPR00987. TRNASYNTHGLU.
    SUPFAMiSSF50715. SSF50715. 1 hit.
    TIGRFAMsiTIGR00463. gltX_arch. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A9A423-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDEEIKHEIR KMALQNAFEH GGQTQDKIIL GKILGTKPEF RTKVKEISGE    50
    ISEIVASVNQ LSPEEQQKEM EEKFPEALAP KEKIEEREGL PELKDAIQGK 100
    VVTRFPPEPN GYPHIGHAKA AIINSEYAKM YGGKFILRMD DTNPEAERME 150
    YHAAIKVGLE WLGIEFDQVK STSDDMEVFY EKGIELINSG KAYVCTCKRE 200
    DISQNRRERK ACKCSMEDVG KNNKNWEKMQ NKFKPGEAIV RFRGDMKADN 250
    AVMRDPVLLR IIDEKHYTVG DKYRIWPSYD FAVAIEDSID GVTHAFRSKE 300
    FELRKELIDA ILDALGMRKP QQGFFSRLEF KGMPISKRII KPLIEEGKVS 350
    WYDDPRLPTL EALRRRGIKP EAIRKFIMSL GLTKANTLAP FDALEAFNRK 400
    FVDADSMRLF MVKNAKKLKI KNLQSTIVEV PNHPINDLGK RKIEITEDFY 450
    ISGDDSEAIK EQSTIRLLGL GNVKITKIGN ELEGEFERDG DSSNILKIQW 500
    VPQKTAHEIK MIIPKILFND EEFNEDSLEE LDVYTEPQYL QLKEGEEIQF 550
    VRFGYCRKDS QNQAIFTHK 569
    Length:569
    Mass (Da):65,521
    Last modified:January 15, 2008 - v1
    Checksum:iE323770539C1B725
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000866 Genomic DNA. Translation: ABX12207.1.
    RefSeqiWP_012214694.1. NC_010085.1.
    YP_001581645.1. NC_010085.1.

    Genome annotation databases

    EnsemblBacteriaiABX12207; ABX12207; Nmar_0311.
    GeneIDi5773999.
    KEGGinmr:Nmar_0311.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000866 Genomic DNA. Translation: ABX12207.1 .
    RefSeqi WP_012214694.1. NC_010085.1.
    YP_001581645.1. NC_010085.1.

    3D structure databases

    ProteinModelPortali A9A423.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 436308.Nmar_0311.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABX12207 ; ABX12207 ; Nmar_0311 .
    GeneIDi 5773999.
    KEGGi nmr:Nmar_0311.

    Phylogenomic databases

    eggNOGi COG0008.
    HOGENOMi HOG000073585.
    KOi K01885.
    OMAi YLGWDDP.

    Enzyme and pathway databases

    BioCyci NMAR436308:GI3J-325-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1160.10. 1 hit.
    2.40.240.10. 2 hits.
    3.40.50.620. 2 hits.
    HAMAPi MF_00022_A. Glu_tRNA_synth_A.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR004526. Glu-tRNA-synth_arc/euk.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
    IPR022888. Glu_tRNA_synth_arc.
    IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
    IPR011035. Ribosomal_L25/Gln-tRNA_synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR10119. PTHR10119. 1 hit.
    Pfami PF00749. tRNA-synt_1c. 1 hit.
    PF03950. tRNA-synt_1c_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00987. TRNASYNTHGLU.
    SUPFAMi SSF50715. SSF50715. 1 hit.
    TIGRFAMsi TIGR00463. gltX_arch. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SCM1.

    Entry informationi

    Entry nameiSYE_NITMS
    AccessioniPrimary (citable) accession number: A9A423
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3