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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Nitrosopumilus maritimus (strain SCM1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:Nmar_0311
OrganismiNitrosopumilus maritimus (strain SCM1)
Taxonomic identifieri436308 [NCBI]
Taxonomic lineageiArchaeaThaumarchaeotaNitrosopumilalesNitrosopumilaceaeNitrosopumilus
Proteomesi
  • UP000000792 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003678041 – 569Glutamate--tRNA ligaseAdd BLAST569

Proteomic databases

PRIDEiA9A423

Interactioni

Protein-protein interaction databases

STRINGi436308.Nmar_0311

Structurei

3D structure databases

ProteinModelPortaliA9A423
SMRiA9A423
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi107 – 117"HIGH" regionUniRule annotationAdd BLAST11

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04302 Archaea
COG0008 LUCA
HOGENOMiHOG000073585
KOiK01885
OMAiMRFAPNP

Family and domain databases

Gene3Di2.40.240.10, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_02076 Glu_tRNA_synth_type2, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR004526 Glu-tRNA-synth_arc/euk
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR020059 Glu/Gln-tRNA-synth_Ib_codon-bd
IPR020056 Rbsml_L25/Gln-tRNA_synth_N
IPR011035 Ribosomal_L25/Gln-tRNA_synth
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PF03950 tRNA-synt_1c_C, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF50715 SSF50715, 1 hit
TIGRFAMsiTIGR00463 gltX_arch, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A9A423-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEEIKHEIR KMALQNAFEH GGQTQDKIIL GKILGTKPEF RTKVKEISGE
60 70 80 90 100
ISEIVASVNQ LSPEEQQKEM EEKFPEALAP KEKIEEREGL PELKDAIQGK
110 120 130 140 150
VVTRFPPEPN GYPHIGHAKA AIINSEYAKM YGGKFILRMD DTNPEAERME
160 170 180 190 200
YHAAIKVGLE WLGIEFDQVK STSDDMEVFY EKGIELINSG KAYVCTCKRE
210 220 230 240 250
DISQNRRERK ACKCSMEDVG KNNKNWEKMQ NKFKPGEAIV RFRGDMKADN
260 270 280 290 300
AVMRDPVLLR IIDEKHYTVG DKYRIWPSYD FAVAIEDSID GVTHAFRSKE
310 320 330 340 350
FELRKELIDA ILDALGMRKP QQGFFSRLEF KGMPISKRII KPLIEEGKVS
360 370 380 390 400
WYDDPRLPTL EALRRRGIKP EAIRKFIMSL GLTKANTLAP FDALEAFNRK
410 420 430 440 450
FVDADSMRLF MVKNAKKLKI KNLQSTIVEV PNHPINDLGK RKIEITEDFY
460 470 480 490 500
ISGDDSEAIK EQSTIRLLGL GNVKITKIGN ELEGEFERDG DSSNILKIQW
510 520 530 540 550
VPQKTAHEIK MIIPKILFND EEFNEDSLEE LDVYTEPQYL QLKEGEEIQF
560
VRFGYCRKDS QNQAIFTHK
Length:569
Mass (Da):65,521
Last modified:January 15, 2008 - v1
Checksum:iE323770539C1B725
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000866 Genomic DNA Translation: ABX12207.1

Genome annotation databases

EnsemblBacteriaiABX12207; ABX12207; Nmar_0311
KEGGinmr:Nmar_0311

Similar proteinsi

Entry informationi

Entry nameiSYE_NITMS
AccessioniPrimary (citable) accession number: A9A423
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: January 15, 2008
Last modified: May 23, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health