A9A3Z0 (A9A3Z0_NITMS) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
DNA polymerase II large subunit HAMAP MF_00324
Short name=Pol II HAMAP MF_00324
EC=2.7.7.7 HAMAP MF_00324

Gene names

Name:	polC HAMAP MF_00324
Ordered Locus Names:	Nmar_1794

Organism

Nitrosopumilus maritimus (strain SCM1)

Taxonomic identifier

436308 [NCBI]

Taxonomic lineage

Archaea › Thaumarchaeota › marine archaeal group 1 › Nitrosopumilales › Nitrosopumilaceae › Nitrosopumilus

Protein attributes

Sequence length	1125 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase By similarity. HAMAP MF_00324
Catalytic activity	Degradation of single-stranded DNA. It acts progressively in a 3'- to 5'-direction, releasing nucleoside 5'-phosphates. HAMAP MF_00324 Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). HAMAP MF_00324
Subunit structure	Heterodimer of a large subunit and a small subunit By similarity. HAMAP MF_00324
Sequence similarities	Belongs to the archaeal DNA polymerase II family. HAMAP MF_00324

Ontologies

Keywords
Biological process	DNA replication HAMAP MF_00324
Ligand	DNA-binding HAMAP MF_00324
Molecular function	DNA-directed DNA polymerase HAMAP MF_00324 Exonuclease HAMAP MF_00324 Hydrolase Nuclease Nucleotidyltransferase Transferase
Technical term	Complete proteome Multifunctional enzyme HAMAP MF_00324 Reference proteome
Gene Ontology (GO)
Biological process	DNA catabolic process, exonucleolytic Inferred from electronic annotation. Source: HAMAP DNA-dependent DNA replication Inferred from electronic annotation. Source: HAMAP
Molecular function	3'-5' exonuclease activity Inferred from electronic annotation. Source: HAMAP DNA binding Inferred from electronic annotation. Source: HAMAP DNA-directed DNA polymerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A9A3Z0 [UniParc]. Last modified January 15, 2008. Version 1. Checksum: 88FD223491C1DFD0	FASTA	1,125	126,137
	10 20 30 40 50 60 MSENDAISRI SGIKMPDYYS DYYSSLSTET YNIFETAASA KSSLVDSSGI IEPKIAFDLA 70 80 90 100 110 120 DRVAKMHEID IAEPLRELLK TNGKELSALI LSKEIAQGKY SLPDSTLEEK LDLAVRVGLA 130 140 150 160 170 180 IVTEGVTIAP LQGISEVKIK KNKDGSEYLS VSIAGPMRSA GGTESAVTML IADHVRKTAG 190 200 210 220 230 240 LSKFQANSFD DETGRFVEEL RIYEREASSF QFHILDEDIE HVISNLPVEL DGVDTDPYEV 250 260 270 280 290 300 VNHKSMARIK TDRVRGGALR VLNDGLIGRS KKLLKRIEMY NLDGWEWLND LKGAVQTGEK 310 320 330 340 350 360 QEDAATKRMH EVITGRSVLS MPNRLGGFRL RYGRACNTGF AAVGLHPVVA EILDHTIAVG 370 380 390 400 410 420 TQIKIDIPGK GSTVAFVDSI ETPVVRLKDG SVVKIRDVKH GIEIKNDIEK ILHLGDILIS 430 440 450 460 470 480 FGDFLENNAQ LVPSGYVEEY WIEELKQKIA KYEPEDHYLT RFLNRIPTID EALKISIDFD 490 500 510 520 530 540 MTLHPHYLYY WDKLSAEELG LLLNPKTINE TSVEYSPQTK KILEKLGVPH IVKNDSIILE 550 560 570 580 590 600 NTEAKIFFNL LFREEPTIDD SSVPQIISKS SGIKIRNKFS TSIGVRIGRP EKSAPRQMKP 610 620 630 640 650 660 PTHVLFPISD KGGPTRDLLK ASRNEHFFTS IYNRHCNQCN IPSIGIKCSK CGTKTTVTYR 670 680 690 700 710 720 CPHCRDSLEE SFCEKCKRNA LAYSHKEFPL KSKLLEAQEK IRLRAQEPFK GVKELISQDK 730 740 750 760 770 780 IAEPLEKGLV RQNFGLTVFK DGTVRFDATN SPLTQFKPSW IGTSVEKLKE LGYSHDVDGI 790 800 810 820 830 840 PLEDPEQIVE LRMQDVIIPY ESGKYLVSIC KYIDTLLEKF YGKTSFYNVT NSEELIGHLI 850 860 870 880 890 900 IGLAPHTSVG IVGRIIGYSE THVCFATPNW HSAKRRDADG DADSIMLLMD SLLNFSRQFL 910 920 930 940 950 960 SDAIGGLMDA PLLVQPLVLP HESQPQAHNL EVTKSLPLEF FESTLQQAKA PDISSVEIIK 970 980 990 1000 1010 1020 SRLETERQFY DYHFTHTTSS LTTSKSRSAY STLGSMLDKF DMQVRNAELI DAVNTSEIVS 1030 1040 1050 1060 1070 1080 DVISTHLVPD IMGNLRAYAR QNFRCTGCGK SYRRMPLIQT CVCGHKLIPT ITRGSVEKYL 1090 1100 1110 1120 KLAKRLVDKY DVSEYQRGRI HALSDEIELV FGKSPGDQSL LTDYA

References

[1]

"Complete sequence of Nitrosopumilus maritimus SCM1." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Stahl D., Richardson P. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SCM1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000866 Genomic DNA. Translation: ABX13690.1.
RefSeq	YP_001583128.1. NC_010085.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A9A3Z0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5773349.
GenomeReviews	Gene locus Nmar_1794 in contig CP000866_GR.
KEGG	nmr:Nmar_1794.
Phylogenomic databases
HOGENOM	HBG497074.
OMA	NCDGDED.
ProtClustDB	PRK04023.
Family and domain databases
HAMAP	MF_00324. DNApol_II_L_arch. [Tree]
InterPro	IPR004475. PolC_DP2. IPR016033. PolC_DP2_N. [Graphical view]
KO	K02322.
Pfam	PF03833. PolC_DP2. 1 hit. [Graphical view]
TIGRFAMs	TIGR00354. PolC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A9A3Z0_NITMS

Accession

Primary (citable) accession number: A9A3Z0

Entry history

Integrated into UniProtKB/TrEMBL:	January 15, 2008
Last sequence update:	January 15, 2008
Last modified:	November 16, 2011
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)