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Protein

Ribonuclease Z

Gene

rnz

Organism
Nitrosopumilus maritimus (strain SCM1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 2 Zn2+ ions.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi60Zinc 1; catalyticUniRule annotation1
Metal bindingi62Zinc 1; catalyticUniRule annotation1
Active sitei64Proton acceptorUniRule annotation1
Metal bindingi64Zinc 2; catalyticUniRule annotation1
Metal bindingi65Zinc 2; catalyticUniRule annotation1
Metal bindingi137Zinc 1; catalyticUniRule annotation1
Metal bindingi207Zinc 1; catalyticUniRule annotation1
Metal bindingi207Zinc 2; catalyticUniRule annotation1
Metal bindingi265Zinc 2; catalyticUniRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease ZUniRule annotation (EC:3.1.26.11UniRule annotation)
Short name:
RNase ZUniRule annotation
Alternative name(s):
tRNA 3 endonucleaseUniRule annotation
tRNase ZUniRule annotation
Gene namesi
Name:rnzUniRule annotation
Ordered Locus Names:Nmar_1776
OrganismiNitrosopumilus maritimus (strain SCM1)
Taxonomic identifieri436308 [NCBI]
Taxonomic lineageiArchaeaThaumarchaeotaNitrosopumilalesNitrosopumilaceaeNitrosopumilus
Proteomesi
  • UP000000792 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001879741 – 299Ribonuclease ZAdd BLAST299

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi436308.Nmar_1776.

Structurei

3D structure databases

ProteinModelPortaliA9A3X2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase Z family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00501. Archaea.
COG1234. LUCA.
HOGENOMiHOG000272419.
KOiK00784.
OMAiSYAFCSD.

Family and domain databases

Gene3Di3.60.15.10. 1 hit.
HAMAPiMF_01818. RNase_Z_BN. 1 hit.
InterProiIPR001279. Metallo-B-lactamas.
IPR013471. RNase_Z/BN.
[Graphical view]
PfamiPF00753. Lactamase_B. 1 hit.
PF12706. Lactamase_B_2. 1 hit.
[Graphical view]
SUPFAMiSSF56281. SSF56281. 1 hit.
TIGRFAMsiTIGR02651. RNase_Z. 1 hit.

Sequencei

Sequence statusi: Complete.

A9A3X2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLVFLGTSA AQPTENRGLS CICLEREGEV LMFDAGEAAQ ISYMKSGLGW
60 70 80 90 100
NKKMKIFVTH LHGDHCVGIL GLLQTMSMQN RTESLEIFGP SGIEEFIAAN
110 120 130 140 150
IKVLNFGLSF PILINTIKDE KIFEDEKFLI RTCKANHSII AFSYLFEEKD
160 170 180 190 200
KPGRFNVEKA KELGIPEGEL WNKLQNGNEI TVNEKIIKPE QVLGERRPGK
210 220 230 240 250
KIGISGDTMP TKELEEFFEE CDYLVFDSTF LEAEKQKAQD TCHSTAKQAA
260 270 280 290
TVAKNAKVKN LVLTHFSARY RDEVEHLREA KEIHDSVITA KDLLEIEIK
Length:299
Mass (Da):33,758
Last modified:January 15, 2008 - v1
Checksum:i85FA72B3C5DF2E1E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000866 Genomic DNA. Translation: ABX13672.1.

Genome annotation databases

EnsemblBacteriaiABX13672; ABX13672; Nmar_1776.
KEGGinmr:Nmar_1776.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000866 Genomic DNA. Translation: ABX13672.1.

3D structure databases

ProteinModelPortaliA9A3X2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi436308.Nmar_1776.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABX13672; ABX13672; Nmar_1776.
KEGGinmr:Nmar_1776.

Phylogenomic databases

eggNOGiarCOG00501. Archaea.
COG1234. LUCA.
HOGENOMiHOG000272419.
KOiK00784.
OMAiSYAFCSD.

Family and domain databases

Gene3Di3.60.15.10. 1 hit.
HAMAPiMF_01818. RNase_Z_BN. 1 hit.
InterProiIPR001279. Metallo-B-lactamas.
IPR013471. RNase_Z/BN.
[Graphical view]
PfamiPF00753. Lactamase_B. 1 hit.
PF12706. Lactamase_B_2. 1 hit.
[Graphical view]
SUPFAMiSSF56281. SSF56281. 1 hit.
TIGRFAMsiTIGR02651. RNase_Z. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRNZ_NITMS
AccessioniPrimary (citable) accession number: A9A3X2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: January 15, 2008
Last modified: November 2, 2016
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.