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A9A3N5

- MTAP_NITMS

UniProt

A9A3N5 - MTAP_NITMS

Protein

S-methyl-5'-thioadenosine phosphorylase

Gene

mtnP

Organism
Nitrosopumilus maritimus (strain SCM1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.UniRule annotation

    Catalytic activityi

    S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei13 – 131PhosphateUniRule annotation
    Sitei168 – 1681Important for substrate specificityUniRule annotation
    Binding sitei186 – 1861Substrate; via amide nitrogenUniRule annotation
    Binding sitei187 – 1871PhosphateUniRule annotation
    Sitei221 – 2211Important for substrate specificityUniRule annotation

    GO - Molecular functioni

    1. phosphorylase activity Source: InterPro
    2. S-methyl-5-thioadenosine phosphorylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. L-methionine biosynthetic process from methylthioadenosine Source: UniProtKB-HAMAP
    2. purine ribonucleoside salvage Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Purine salvage

    Enzyme and pathway databases

    BioCyciNMAR436308:GI3J-1436-MONOMER.
    UniPathwayiUPA00904; UER00873.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    S-methyl-5'-thioadenosine phosphorylaseUniRule annotation (EC:2.4.2.28UniRule annotation)
    Alternative name(s):
    5'-methylthioadenosine phosphorylaseUniRule annotation
    Short name:
    MTA phosphorylaseUniRule annotation
    Short name:
    MTAPUniRule annotation
    Gene namesi
    Name:mtnPUniRule annotation
    Ordered Locus Names:Nmar_1401
    OrganismiNitrosopumilus maritimus (strain SCM1)
    Taxonomic identifieri436308 [NCBI]
    Taxonomic lineageiArchaeaThaumarchaeotaNitrosopumilalesNitrosopumilaceaeNitrosopumilus
    ProteomesiUP000000792: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 263263S-methyl-5'-thioadenosine phosphorylasePRO_0000415105Add
    BLAST

    Interactioni

    Subunit structurei

    Homohexamer. Dimer of a homotrimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi436308.Nmar_1401.

    Structurei

    3D structure databases

    ProteinModelPortaliA9A3N5.
    SMRiA9A3N5. Positions 3-261.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni55 – 562Phosphate bindingUniRule annotation
    Regioni88 – 892Phosphate bindingUniRule annotation
    Regioni210 – 2123Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0005.
    HOGENOMiHOG000228986.
    KOiK00772.
    OMAiCEAQLCY.

    Family and domain databases

    Gene3Di3.40.50.1580. 1 hit.
    HAMAPiMF_01963. MTAP.
    InterProiIPR010044. MTAP.
    IPR000845. Nucleoside_phosphorylase_d.
    IPR001369. PNP/MTAP.
    IPR018099. Purine_phosphorylase-2_CS.
    [Graphical view]
    PANTHERiPTHR11904. PTHR11904. 1 hit.
    PfamiPF01048. PNP_UDP_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF53167. SSF53167. 1 hit.
    TIGRFAMsiTIGR01694. MTAP. 1 hit.
    PROSITEiPS01240. PNP_MTAP_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A9A3N5-1 [UniParc]FASTAAdd to Basket

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    MEKDVEIGIF GGTGIYDSGL LEDAKEVDID TPYGKPSDTI TVGTFKGRKI    50
    AFLPRHGKKH TIPPHMINFK ANIWAFKELG VTRIIAPSAV GSLKEELAPG 100
    HFVLPTQFLD FTKSRDGSFS EDGRVIHISV ADPFCPELQS SITEVTDSLD 150
    MNIHKDCTYV CIEGPRFSTK AESKFYRTTG ADIIGMTLVP ECQLAREAQI 200
    CYASISTVTD YDVWAEKPVT AKEVLETLSK NVEGTKKILT ELIEKIPKDR 250
    SCSCAKALEE AEF 263
    Length:263
    Mass (Da):29,043
    Last modified:January 15, 2008 - v1
    Checksum:iF42286B331B3BFF9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000866 Genomic DNA. Translation: ABX13297.1.
    RefSeqiYP_001582735.1. NC_010085.1.

    Genome annotation databases

    EnsemblBacteriaiABX13297; ABX13297; Nmar_1401.
    GeneIDi5773440.
    KEGGinmr:Nmar_1401.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000866 Genomic DNA. Translation: ABX13297.1 .
    RefSeqi YP_001582735.1. NC_010085.1.

    3D structure databases

    ProteinModelPortali A9A3N5.
    SMRi A9A3N5. Positions 3-261.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 436308.Nmar_1401.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABX13297 ; ABX13297 ; Nmar_1401 .
    GeneIDi 5773440.
    KEGGi nmr:Nmar_1401.

    Phylogenomic databases

    eggNOGi COG0005.
    HOGENOMi HOG000228986.
    KOi K00772.
    OMAi CEAQLCY.

    Enzyme and pathway databases

    UniPathwayi UPA00904 ; UER00873 .
    BioCyci NMAR436308:GI3J-1436-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.1580. 1 hit.
    HAMAPi MF_01963. MTAP.
    InterProi IPR010044. MTAP.
    IPR000845. Nucleoside_phosphorylase_d.
    IPR001369. PNP/MTAP.
    IPR018099. Purine_phosphorylase-2_CS.
    [Graphical view ]
    PANTHERi PTHR11904. PTHR11904. 1 hit.
    Pfami PF01048. PNP_UDP_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53167. SSF53167. 1 hit.
    TIGRFAMsi TIGR01694. MTAP. 1 hit.
    PROSITEi PS01240. PNP_MTAP_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SCM1.

    Entry informationi

    Entry nameiMTAP_NITMS
    AccessioniPrimary (citable) accession number: A9A3N5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 25, 2012
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3