A9A3M4 (A9A3M4_NITMS) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Dihydroorotate dehydrogenase HAMAP MF_00224
Short name=DHOD HAMAP MF_00224
Short name=DHODase HAMAP MF_00224
Short name=DHOdehase HAMAP MF_00224
EC=1.3.-.- HAMAP MF_00224

Gene names

Name:	pyrD HAMAP MF_00224
Ordered Locus Names:	Nmar_1390

Organism

Nitrosopumilus maritimus (strain SCM1)

Taxonomic identifier

436308 [NCBI]

Taxonomic lineage

Archaea › Thaumarchaeota › marine archaeal group 1 › Nitrosopumilales › Nitrosopumilaceae › Nitrosopumilus

Protein attributes

Sequence length	303 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of dihydroorotate to orotate By similarity. HAMAP MF_00224
Catalytic activity	(S)-dihydroorotate + acceptor = orotate + reduced acceptor. HAMAP MF_00224
Cofactor	Binds 1 FMN per subunit By similarity. HAMAP MF_00224
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway. HAMAP MF_00224
Subcellular location	Cytoplasm By similarity HAMAP MF_00224.
Sequence similarities	Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. HAMAP MF_00224

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis HAMAP MF_00224
Cellular component	Cytoplasm HAMAP MF_00224
Ligand	FMN HAMAP MF_00224 Flavoprotein HAMAP MF_00224
Molecular function	Oxidoreductase HAMAP MF_00224
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro UMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	dihydroorotate oxidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	128	1	Nucleophile By similarity PIRSR PIRSR000164-1

Sequences

	Sequence		Length	Mass (Da)
	A9A3M4 [UniParc]. Last modified January 15, 2008. Version 1. Checksum: 4A99F157B76AE3F4	FASTA	303	32,454
	10 20 30 40 50 60 MEPNLATSIG PIQLDRPVML ASGILGISLD VFSRLYRSGA GAVVTKSLST EPWEGYPNPT 70 80 90 100 110 120 IFSVKGGGWI NAVGLSNPGA ENFAKMIEPN QDVPIIVSLV GSIPEDFEKM IKQFENCKVT 130 140 150 160 170 180 AYELNLSCPH VAKVGLEVGD DPELVKKIVT TVKNSTNVPV IAKVGLGTTH YLNTVGTAIE 190 200 210 220 230 240 SGIDAITAIN TVRSMAIDVE TQRPILSNKF GGLSGTPIKP IALRCVYEIS SKYDIPIIGC 250 260 270 280 290 300 GGISTWEDAV EFFLAGASSV QLGSAIGDNW IDVFNEINTG ILQYMEKKNY SKIEEMIGLA KKS

References

[1]

"Complete sequence of Nitrosopumilus maritimus SCM1." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Stahl D., Richardson P. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SCM1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000866 Genomic DNA. Translation: ABX13286.1.
RefSeq	YP_001582724.1. NC_010085.1.
3D structure databases
ProteinModelPortal	A9A3M4.
ModBase	Search...
Protein-protein interaction databases
STRING	A9A3M4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5773393.
GenomeReviews	Gene locus Nmar_1390 in contig CP000866_GR.
KEGG	nmr:Nmar_1390.
Phylogenomic databases
HOGENOM	HBG472415.
OMA	VALRMVW.
Family and domain databases
HAMAP	MF_00224. DHO_dh_type1. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR005720. Dihydroorotate_DH. IPR024920. Dihydroorotate_DH_1. IPR012135. Dihydroorotate_DH_1_2. IPR001295. Dihydroorotate_DH_CS. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K00226.
Pfam	PF01180. DHO_dh. 1 hit. [Graphical view]
PIRSF	PIRSF000164. DHO_oxidase. 1 hit.
TIGRFAMs	TIGR01037. PyrD_sub1_fam. 1 hit.
PROSITE	PS00912. DHODEHASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A9A3M4_NITMS

Accession

Primary (citable) accession number: A9A3M4

Entry history

Integrated into UniProtKB/TrEMBL:	January 15, 2008
Last sequence update:	January 15, 2008
Last modified:	January 25, 2012
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)