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A9A3K1

- DNLI_NITMS

UniProt

A9A3K1 - DNLI_NITMS

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Protein

DNA ligase

Gene

lig

Organism
Nitrosopumilus maritimus (strain SCM1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei250 – 2501ATPUniRule annotation
Active sitei252 – 2521N6-AMP-lysine intermediateUniRule annotation
Binding sitei257 – 2571ATPUniRule annotation
Binding sitei272 – 2721ATPUniRule annotation
Binding sitei302 – 3021ATPUniRule annotation
Binding sitei342 – 3421ATPUniRule annotation
Binding sitei417 – 4171ATPUniRule annotation
Binding sitei423 – 4231ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA biosynthetic process Source: InterPro
  4. DNA ligation involved in DNA repair Source: InterPro
  5. DNA recombination Source: UniProtKB-HAMAP
  6. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciNMAR436308:GI3J-1068-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Nmar_1037
OrganismiNitrosopumilus maritimus (strain SCM1)
Taxonomic identifieri436308 [NCBI]
Taxonomic lineageiArchaeaThaumarchaeotaNitrosopumilalesNitrosopumilaceaeNitrosopumilus
ProteomesiUP000000792: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 588588DNA ligasePRO_0000365263Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi436308.Nmar_1037.

Structurei

3D structure databases

ProteinModelPortaliA9A3K1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036008.
KOiK10747.
OMAiMVKMLEG.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9A3K1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEFSILADSF NKMESTRKRL ELTQYLVELF KKTPQEVISK IVYLLQGKLR
60 70 80 90 100
PDFEGVELGV AEKLAIRAIS KSSGIPIKKI EEEYRKGGDL GHAATTILEQ
110 120 130 140 150
KTQTTFLVED ITVERVYETL FKIAKLEGNR SQDMKMKYIS SLLNDASPLE
160 170 180 190 200
ASFILKILLG TLRLGIAENT VMDALALAFS GNKENRKILE HAYNVSSDLG
210 220 230 240 250
KVAEVLATEG LAEVEKFKII LFNPIRPMLA DRVKSEQEAI EKMGNEFAAE
260 270 280 290 300
YKLDGERVQL HIEGDKVVLF SRSLENISSY YPDIIEKIPK TIQAENIVLE
310 320 330 340 350
AEAVAINENT GEFLPFQELM HRRRKYKIEK AVTQYPITVN LFDILYCNGK
360 370 380 390 400
SCLELDYKER REKMEKVVKE DDFVKHIPMA IVKNENDIED FFENSINAGS
410 420 430 440 450
EGLMLKTLVS PYQAGSRGSH WLKLKREYQN ELGDSLDLVV IGGFFGKGRR
460 470 480 490 500
TGNYGTLLLA TYEEDEDTFT SICKVGTGFS DEDLDQLYQI LNPKVTIKKN
510 520 530 540 550
PRINSEMEAD VWFEPELVIE VVASEITLSP IHKAARDKIR KGAGLALRFP
560 570 580
KFTGKMRVEK MAEDASTNEE VITLYQGQKK VAHDKSLM
Length:588
Mass (Da):66,661
Last modified:January 15, 2008 - v1
Checksum:i60A94750BF81C85B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000866 Genomic DNA. Translation: ABX12933.1.
RefSeqiWP_012215420.1. NC_010085.1.
YP_001582371.1. NC_010085.1.

Genome annotation databases

EnsemblBacteriaiABX12933; ABX12933; Nmar_1037.
GeneIDi5773689.
KEGGinmr:Nmar_1037.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000866 Genomic DNA. Translation: ABX12933.1 .
RefSeqi WP_012215420.1. NC_010085.1.
YP_001582371.1. NC_010085.1.

3D structure databases

ProteinModelPortali A9A3K1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 436308.Nmar_1037.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX12933 ; ABX12933 ; Nmar_1037 .
GeneIDi 5773689.
KEGGi nmr:Nmar_1037.

Phylogenomic databases

eggNOGi COG1793.
HOGENOMi HOG000036008.
KOi K10747.
OMAi MVKMLEG.

Enzyme and pathway databases

BioCyci NMAR436308:GI3J-1068-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SCM1.

Entry informationi

Entry nameiDNLI_NITMS
AccessioniPrimary (citable) accession number: A9A3K1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: January 15, 2008
Last modified: November 26, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3