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A9A3K1 (DNLI_NITMS) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA ligase

EC=6.5.1.1
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene names
Name:lig
Ordered Locus Names:Nmar_1037
OrganismNitrosopumilus maritimus (strain SCM1) [Reference proteome] [HAMAP]
Taxonomic identifier436308 [NCBI]
Taxonomic lineageArchaeaThaumarchaeotaNitrosopumilalesNitrosopumilaceaeNitrosopumilus

Protein attributes

Sequence length588 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). HAMAP-Rule MF_00407

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 588588DNA ligase HAMAP-Rule MF_00407
PRO_0000365263

Sites

Active site2521N6-AMP-lysine intermediate By similarity
Binding site2501ATP By similarity
Binding site2571ATP By similarity
Binding site2721ATP By similarity
Binding site3021ATP By similarity
Binding site3421ATP By similarity
Binding site4171ATP By similarity
Binding site4231ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A9A3K1 [UniParc].

Last modified January 15, 2008. Version 1.
Checksum: 60A94750BF81C85B

FASTA58866,661
        10         20         30         40         50         60 
MEFSILADSF NKMESTRKRL ELTQYLVELF KKTPQEVISK IVYLLQGKLR PDFEGVELGV 

        70         80         90        100        110        120 
AEKLAIRAIS KSSGIPIKKI EEEYRKGGDL GHAATTILEQ KTQTTFLVED ITVERVYETL 

       130        140        150        160        170        180 
FKIAKLEGNR SQDMKMKYIS SLLNDASPLE ASFILKILLG TLRLGIAENT VMDALALAFS 

       190        200        210        220        230        240 
GNKENRKILE HAYNVSSDLG KVAEVLATEG LAEVEKFKII LFNPIRPMLA DRVKSEQEAI 

       250        260        270        280        290        300 
EKMGNEFAAE YKLDGERVQL HIEGDKVVLF SRSLENISSY YPDIIEKIPK TIQAENIVLE 

       310        320        330        340        350        360 
AEAVAINENT GEFLPFQELM HRRRKYKIEK AVTQYPITVN LFDILYCNGK SCLELDYKER 

       370        380        390        400        410        420 
REKMEKVVKE DDFVKHIPMA IVKNENDIED FFENSINAGS EGLMLKTLVS PYQAGSRGSH 

       430        440        450        460        470        480 
WLKLKREYQN ELGDSLDLVV IGGFFGKGRR TGNYGTLLLA TYEEDEDTFT SICKVGTGFS 

       490        500        510        520        530        540 
DEDLDQLYQI LNPKVTIKKN PRINSEMEAD VWFEPELVIE VVASEITLSP IHKAARDKIR 

       550        560        570        580 
KGAGLALRFP KFTGKMRVEK MAEDASTNEE VITLYQGQKK VAHDKSLM 

« Hide

References

[1]"Complete sequence of Nitrosopumilus maritimus SCM1."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Stahl D., Richardson P.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SCM1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000866 Genomic DNA. Translation: ABX12933.1.
RefSeqYP_001582371.1. NC_010085.1.

3D structure databases

ProteinModelPortalA9A3K1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING436308.Nmar_1037.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABX12933; ABX12933; Nmar_1037.
GeneID5773689.
KEGGnmr:Nmar_1037.

Phylogenomic databases

eggNOGCOG1793.
HOGENOMHOG000036008.
KOK10747.
OMAMVKMLEG.

Enzyme and pathway databases

BioCycNMAR436308:GI3J-1068-MONOMER.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDNLI_NITMS
AccessionPrimary (citable) accession number: A9A3K1
Entry history
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: January 15, 2008
Last modified: May 14, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families