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A9A3C5 (A9A3C5_NITMS) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Proline--tRNA ligase HAMAP MF_01571
EC=6.1.1.15 HAMAP MF_01571
Alternative name(s):
Prolyl-tRNA synthetase HAMAP MF_01571
Gene names
Name:proS HAMAP MF_01571
Ordered Locus Names:Nmar_0658
OrganismNitrosopumilus maritimus (strain SCM1)
Taxonomic identifier436308 [NCBI]
Taxonomic lineageArchaea › Thaumarchaeota › marine archaeal group 1 › Nitrosopumilales › Nitrosopumilaceae › Nitrosopumilus

Protein attributes

Sequence length480 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro) By similarity. HAMAP MF_01571

Catalytic activity

ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro). HAMAP MF_01571

Subunit structure

Homodimer By similarity. HAMAP MF_01571

Subcellular location

Cytoplasm By similarity HAMAP MF_01571.

Domain

Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension By similarity. HAMAP MF_01571

Sequence similarities

Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily. HAMAP MF_01571

Sequences

Sequence LengthMass (Da)Tools
A9A3C5 [UniParc].

Last modified January 15, 2008. Version 1.
Checksum: 22B965DD785657B2

FASTA48054,937
        10         20         30         40         50         60 
MSKEDVGITV SKNEDFSEWY TQVVLKAKLA DYAPVKGLIV LRPDGHSIWE SLKNTFDKKF 

        70         80         90        100        110        120 
AKNGIRNGFL PVLIPESLLG KEQKHFAGFN PEVFWVTHSG TNEIGDRLAL RPTSETLAYT 

       130        140        150        160        170        180 
LYSKWIQSWR DLPLKINFWN TALRAEIKAT KPFLRTSEFL WQEGHTVHIT QEEAEQEVMK 

       190        200        210        220        230        240 
ILDIYKNTVE EELAIPVTTG KKSEKEKFVG AVYTTTMESI MPDGKALQMG TSHFLGQNFS 

       250        260        270        280        290        300 
KPFEVKFADK DNVEHFAWQT SWGVSWRLIG AMIMAHGDDQ GLVLPPKVAP TQVVIVPIYR 

       310        320        330        340        350        360 
NDEGRDKVLP KVKEIQESLE AKDIRVQVDD RQGLSPGYKF NDWEMKGVPI RIEIGPKDIE 

       370        380        390        400        410        420 
KQSIVVAKRY NREKTNLQFS EIEKVVEVLD EIQKNMLEKA REQSKENTKY VSDYTEFKLK 

       430        440        450        460        470        480 
IEEGGFFNAP WCGKLECEEK IKEETGADIR VIPFGSEDTN SKCMYCGEQS KSIPIFARGY

« Hide

References

[1]"Complete sequence of Nitrosopumilus maritimus SCM1."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Stahl D., Richardson P.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SCM1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000866 Genomic DNA. Translation: ABX12554.1.
RefSeqYP_001581992.1. NC_010085.1.

3D structure databases

ProteinModelPortalA9A3C5.
ModBaseSearch...

Protein-protein interaction databases

STRINGA9A3C5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5773815.
GenomeReviewsGene locus Nmar_0658 in contig CP000866_GR.
KEGGnmr:Nmar_0658.

Phylogenomic databases

HOGENOMHBG334108.
OMAKFAEYEL.

Family and domain databases

HAMAPMF_01571. Pro_tRNA_synth_type3.
[Tree]
InterProIPR002314. aa-tRNA-synt_IIb_cons-dom.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR002316. Pro-tRNA-synth_IIa.
IPR004499. Pro-tRNA-synth_IIa_arc-type.
IPR017449. Pro-tRNA_synth_II.
IPR016061. Pro-tRNA_synth_II_C.
[Graphical view]
Gene3DG3DSA:3.40.50.800. Anticodon_bd. 1 hit.
G3DSA:3.30.110.30. Pro-tRNA-synth_II_C_arc/euk. 1 hit.
KOK01881.
PANTHERPTHR11451:SF6. ProS_fam_I. 1 hit.
PfamPF03129. HGTP_anticodon. 1 hit.
PF09180. ProRS-C_1. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
[Graphical view]
PRINTSPR01046. TRNASYNTHPRO.
SMARTSM00946. ProRS-C_1. 1 hit.
[Graphical view]
SUPFAMSSF52954. Anticodon_bd. 1 hit.
SSF64586. Pro-tRNA_synth_II_C. 1 hit.
TIGRFAMsTIGR00408. ProS_fam_I. 1 hit.
PROSITEPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA9A3C5_NITMS
AccessionPrimary (citable) accession number: A9A3C5
Entry history
Integrated into UniProtKB/TrEMBL: January 15, 2008
Last sequence update: January 15, 2008
Last modified: January 25, 2012
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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