A9A331 (ARLY_NITMS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1

Alternative name(s):
Arginosuccinase

Gene names

Name:	argH
Ordered Locus Names:	Nmar_0263

Organism

Nitrosopumilus maritimus (strain SCM1)

Taxonomic identifier

436308 [NCBI]

Taxonomic lineage

Archaea › Thaumarchaeota › marine archaeal group 1 › Nitrosopumilales › Nitrosopumilaceae › Nitrosopumilus

Protein attributes

Sequence length	485 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006
Subcellular location	Cytoplasm By similarity HAMAP MF_00006.
Sequence similarities	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process via ornithine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	argininosuccinate lyase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 485	485	Argininosuccinate lyase HAMAP MF_00006		PRO_1000089098

Sequences

	Sequence		Length	Mass (Da)
	A9A331 [UniParc]. Last modified January 15, 2008. Version 1. Checksum: CA196362C310B921	FASTA	485	53,923
	10 20 30 40 50 60 MYRSRLGNDL SDITLDYVSS IDDDAAITFY DIVGSQAHVL MLYQQKIITK SDAKKILSSL 70 80 90 100 110 120 ESLKDETFDS SSGAEDIHEL IEALVIKRAG MSSGGKMHTA RSRNDQVVLD IRMKIRDDIN 130 140 150 160 170 180 IICNCLLDTI EALVSVAKNH QKTIMPLYTH LQQAQAGLFS HYLLAHADVL SRDFQRLYGT 190 200 210 220 230 240 FERINQSPLG AGPVGGTSIS IDRRSTAKML GFDDVVENSI DATSTRDFVA EYVSMVSILM 250 260 270 280 290 300 TNLSKIAEDF VIWSTSEFSF IELSDEFTSP SSVMPQKKNP DILELTRGKT SEVIGNLTAI 310 320 330 340 350 360 LTTVKGLASG YGRDLQQIKS SIWSTSKISI SALLIFKSML LTLKVNEKQM KKVTESSNLI 370 380 390 400 410 420 ALDIAEKLVQ EGIPFRVTHK IAGSLTQLAH LSKKPISKLT PSDIKKSVAD TKVDPKLVLE 430 440 450 460 470 480 IISSITVVSS LKERKSYGSS GYDEQKRMIS DRLKKINDFR TDLTHRENKI NSSLEDLKKQ IDEII

References

[1]

"Complete sequence of Nitrosopumilus maritimus SCM1." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Stahl D., Richardson P. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SCM1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000866 Genomic DNA. Translation: ABX12159.1.
RefSeq	YP_001581597.1. NC_010085.1.
3D structure databases
ProteinModelPortal	A9A331.
ModBase	Search...
Protein-protein interaction databases
STRING	A9A331.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5773991.
GenomeReviews	Gene locus Nmar_0263 in contig CP000866_GR.
KEGG	nmr:Nmar_0263.
Phylogenomic databases
HOGENOM	HBG539632.
OMA	EDIHTVI.
Family and domain databases
HAMAP	MF_00006. Arg_succ_lyase. [Tree]
InterPro	IPR009049. Argininosuccinate_lyase. IPR003031. D_crystallin. IPR000362. Fumarate_lyase. IPR008948. L-Aspartase-like. IPR022761. Lyase1_N. [Graphical view]
KO	K01755.
PANTHER	PTHR11444:SF3. argH. 1 hit.
Pfam	PF00206. Lyase_1. 1 hit. [Graphical view]
PRINTS	PR00145. ARGSUCLYASE. PR00149. FUMRATELYASE.
SUPFAM	SSF48557. L-Aspartase-like. 1 hit.
TIGRFAMs	TIGR00838. ArgH. 1 hit.
PROSITE	PS00163. FUMARATE_LYASES. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARLY_NITMS

Accession

Primary (citable) accession number: A9A331

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	January 15, 2008
Last modified:	January 25, 2012
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program