ID   A9A2N6_NITMS            Unreviewed;       343 AA.
AC   A9A2N6;
DT   15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT   15-JAN-2008, sequence version 1.
DT   27-MAR-2024, entry version 83.
DE   SubName: Full=Isocitrate dehydrogenase (NAD(+)) {ECO:0000313|EMBL:ABX13275.1};
DE            EC=1.1.1.41 {ECO:0000313|EMBL:ABX13275.1};
GN   OrderedLocusNames=Nmar_1379 {ECO:0000313|EMBL:ABX13275.1};
OS   Nitrosopumilus maritimus (strain SCM1).
OC   Archaea; Nitrososphaerota; Nitrososphaeria; Nitrosopumilales;
OC   Nitrosopumilaceae; Nitrosopumilus.
OX   NCBI_TaxID=436308 {ECO:0000313|EMBL:ABX13275.1, ECO:0000313|Proteomes:UP000000792};
RN   [1] {ECO:0000313|EMBL:ABX13275.1, ECO:0000313|Proteomes:UP000000792}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SCM1 {ECO:0000313|EMBL:ABX13275.1,
RC   ECO:0000313|Proteomes:UP000000792};
RX   PubMed=20421470; DOI=10.1073/pnas.0913533107;
RA   Walker C.B., de la Torre J.R., Klotz M.G., Urakawa H., Pinel N., Arp D.J.,
RA   Brochier-Armanet C., Chain P.S., Chan P.P., Gollabgir A., Hemp J.,
RA   Hugler M., Karr E.A., Konneke M., Shin M., Lawton T.J., Lowe T.,
RA   Martens-Habbena W., Sayavedra-Soto L.A., Lang D., Sievert S.M.,
RA   Rosenzweig A.C., Manning G., Stahl D.A.;
RT   "Nitrosopumilus maritimus genome reveals unique mechanisms for
RT   nitrification and autotrophy in globally distributed marine crenarchaea.";
RL   Proc. Natl. Acad. Sci. U.S.A. 107:8818-8823(2010).
CC   -!- SIMILARITY: Belongs to the isocitrate and isopropylmalate
CC       dehydrogenases family. {ECO:0000256|ARBA:ARBA00007769}.
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DR   EMBL; CP000866; ABX13275.1; -; Genomic_DNA.
DR   AlphaFoldDB; A9A2N6; -.
DR   STRING; 436308.Nmar_1379; -.
DR   EnsemblBacteria; ABX13275; ABX13275; Nmar_1379.
DR   KEGG; nmr:Nmar_1379; -.
DR   eggNOG; arCOG01163; Archaea.
DR   HOGENOM; CLU_031953_0_1_2; -.
DR   InParanoid; A9A2N6; -.
DR   OrthoDB; 6813at2157; -.
DR   PhylomeDB; A9A2N6; -.
DR   Proteomes; UP000000792; Chromosome.
DR   GO; GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; IBA:GO_Central.
DR   GO; GO:0006102; P:isocitrate metabolic process; IBA:GO_Central.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IBA:GO_Central.
DR   Gene3D; 3.40.718.10; Isopropylmalate Dehydrogenase; 1.
DR   InterPro; IPR024084; IsoPropMal-DH-like_dom.
DR   PANTHER; PTHR11835; DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE; 1.
DR   PANTHER; PTHR11835:SF77; ISOCITRATE_ISOPROPYLMALATE DEHYDROGENASE FAMILY PROTEIN; 1.
DR   Pfam; PF00180; Iso_dh; 1.
DR   SMART; SM01329; Iso_dh; 1.
DR   SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000313|EMBL:ABX13275.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000792}.
FT   DOMAIN          4..333
FT                   /note="Isopropylmalate dehydrogenase-like"
FT                   /evidence="ECO:0000259|SMART:SM01329"
SQ   SEQUENCE   343 AA;  37744 MW;  22283814BBED8DE3 CRC64;
     MSKKAAVMKG DGIGPEVVDS MLRVLKECNF QSELILCEAG SEQWDKNGRK DASYIPDVTM
     KILEETDCCF KGPTTTIPVP GAPRSVAVTL RQKFDLYANI RPTKTYDRLT PDRKLDCVCF
     REATEGLYTG VEAKITDDAA IAIRKITRQG SRRLIDSAVD WANKFNMKKM VAVTKRNILK
     QTDGIFWDET QKAVEGTDIE LSEIYIDNMA QQMVIATEQF NGAVLVSTNL FMDIISELAS
     ALVGSIGLIY SANIGDNYAM FEAAHGSAPQ FAGQNKVNPT ATVLSGAWMA DYLGERDVRD
     AIFAATEQVI NEGKAVTWDI GGDASTTQMT DAIITYAKEK LRK
//