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Protein

Adenosylhomocysteinase

Gene

Nmar_0964

Organism
Nitrosopumilus maritimus (strain SCM1)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine.UniRule annotation

Cofactori

NAD+UniRule annotationNote: Binds 1 NAD+ per subunit.UniRule annotation

Pathwayi: L-homocysteine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Adenosylhomocysteinase (Nmar_0964)
This subpathway is part of the pathway L-homocysteine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine, the pathway L-homocysteine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei53SubstrateUniRule annotation1
Binding sitei124SubstrateUniRule annotation1
Binding sitei149SubstrateUniRule annotation1
Binding sitei179SubstrateUniRule annotation1
Binding sitei183SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationImported
Biological processOne-carbon metabolismUniRule annotation
LigandNADUniRule annotation

Enzyme and pathway databases

BioCyciNMAR436308:GI3J-989-MONOMER.
UniPathwayiUPA00314; UER00076.

Names & Taxonomyi

Protein namesi
Recommended name:
AdenosylhomocysteinaseUniRule annotation (EC:3.3.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Nmar_0964Imported
OrganismiNitrosopumilus maritimus (strain SCM1)Imported
Taxonomic identifieri436308 [NCBI]
Taxonomic lineageiArchaeaThaumarchaeotaNitrosopumilalesNitrosopumilaceaeNitrosopumilus
Proteomesi
  • UP000000792 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi436308.Nmar_0964.

Structurei

3D structure databases

ProteinModelPortaliA9A2E9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini184 – 345AdoHcyase_NADInterPro annotationAdd BLAST162

Sequence similaritiesi

Belongs to the adenosylhomocysteinase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04137. Archaea.
COG0499. LUCA.
HOGENOMiHOG000227987.
KOiK01251.
OMAiQPTHLCE.

Family and domain databases

CDDicd00401. SAHH. 1 hit.
InterProiView protein in InterPro
IPR000043. Adenosylhomocysteinase-like.
IPR015878. Ado_hCys_hydrolase_NAD-bd.
IPR036291. NAD(P)-bd_dom_sf.
PANTHERiPTHR23420. PTHR23420. 1 hit.
PfamiView protein in Pfam
PF05221. AdoHcyase. 2 hits.
PF00670. AdoHcyase_NAD. 1 hit.
PIRSFiPIRSF001109. Ad_hcy_hydrolase. 1 hit.
SMARTiView protein in SMART
SM00996. AdoHcyase. 1 hit.
SM00997. AdoHcyase_NAD. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00936. ahcY. 1 hit.

Sequencei

Sequence statusi: Complete.

A9A2E9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKVKSSAKL IKEGKLSYEW ARSHMQILDN TINRLKKSKP LKGVTLGFCL
60 70 80 90 100
HITKETSVLL MGAKELGATV ACCGGNPLTT QDNIAAFLAS QGIHVYAWHG
110 120 130 140 150
QSVKEYDWCI DQVLKHKPTI LTDDGADMNV KAHFDKRFKN MKILGATEET
160 170 180 190 200
TAGVTRIRAV ENQGKLRYPV ILVNEAYTKH MFDNRYGTGQ STIDGYLRAM
210 220 230 240 250
NLLMASKRVV VVGYGWVGRG VAARCHGMGS KVIVTEIDPV KALEAHMDGF
260 270 280 290 300
EVMPMAQATK LGDIFITCTG MTSVIRKEHI LKMKDGAIMG NVGHFDVEID
310 320 330 340 350
SEFLLKKSKS VKEVRPALDE CVLKNGKKVY LIGQGRLANL VAAEGHPPEV
360 370 380 390 400
MAQSFSNQIL SVMYILKNHK KMENKIINVP EEIDTQVAVD ALKAMDVKID
410
KLTPEQVKYA NSW
Length:413
Mass (Da):45,766
Last modified:January 15, 2008 - v1
Checksum:i0A5FBDBF3B15EBA5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000866 Genomic DNA. Translation: ABX12860.1.

Genome annotation databases

EnsemblBacteriaiABX12860; ABX12860; Nmar_0964.
KEGGinmr:Nmar_0964.

Similar proteinsi

Entry informationi

Entry nameiA9A2E9_NITMS
AccessioniPrimary (citable) accession number: A9A2E9
Entry historyiIntegrated into UniProtKB/TrEMBL: January 15, 2008
Last sequence update: January 15, 2008
Last modified: February 28, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported