A9A2E4 (ILVC_NITMS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ketol-acid reductoisomerase
EC=1.1.1.86

Alternative name(s):
Acetohydroxy-acid isomeroreductase
Alpha-keto-beta-hydroxylacil reductoisomerase

Gene names

Name:	ilvC
Ordered Locus Names:	Nmar_0959

Organism

Nitrosopumilus maritimus (strain SCM1)

Taxonomic identifier

436308 [NCBI]

Taxonomic lineage

Archaea › Thaumarchaeota › marine archaeal group 1 › Nitrosopumilales › Nitrosopumilaceae › Nitrosopumilus

Protein attributes

Sequence length	332 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH. HAMAP MF_00435 (2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH. HAMAP MF_00435
Pathway	Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4. HAMAP MF_00435 Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4. HAMAP MF_00435
Sequence similarities	Belongs to the ketol-acid reductoisomerase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Branched-chain amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	branched chain family amino acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro ketol-acid reductoisomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 332	332	Ketol-acid reductoisomerase HAMAP MF_00435		PRO_1000124313
Sites
	Active site	108	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	A9A2E4 [UniParc]. Last modified January 15, 2008. Version 1. Checksum: F39D2836C872BBD9	FASTA	332	36,962
	10 20 30 40 50 60 MAQTWKDTDI SLDPIKDQTI AVIGYGIQGD AQANNMKDSG LNVIIGLKEG GNSWKKAEAD 70 80 90 100 110 120 GHKVMSVADA TKQADIIHIL IPDMIQGQVY KDEIGPNLSE GKALSFSHAA AIYWKWIEAP 130 140 150 160 170 180 NNVDLIMIAP KGPGSKVRET YLDNFGTPAI VAVEQDFTGK AWDRTLGIAK AIGSARAGLI 190 200 210 220 230 240 KTAFKEEVET DWFGEQADLC GGAASMVTNA FETLVEAGYQ PEIAYFEVLH ELKLIVDMIQ 250 260 270 280 290 300 RYGINGMWRR VSETARYGGL TRGPMVMDSA NKENMKKVLT MIQDGTFNNE WISEYQKNGK 310 320 330 DAFDKYMKQY DEHQIEKVGK EMRKMMWPDS TE

References

[1]

"Complete sequence of Nitrosopumilus maritimus SCM1." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Stahl D., Richardson P. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SCM1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000866 Genomic DNA. Translation: ABX12855.1.
RefSeq	YP_001582293.1. NC_010085.1.
3D structure databases
ProteinModelPortal	A9A2E4.
ModBase	Search...
Protein-protein interaction databases
STRING	A9A2E4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5772995.
GenomeReviews	Gene locus Nmar_0959 in contig CP000866_GR.
KEGG	nmr:Nmar_0959.
Phylogenomic databases
HOGENOM	HBG286525.
OMA	MAYAKGI.
Family and domain databases
HAMAP	MF_00435. IlvC. [Tree]
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR013023. AcH_isomrdctse. IPR000506. AcH_isomrdctse_C. IPR013328. DH_multihelical. IPR013116. IlvN. [Graphical view]
Gene3D	G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KO	K00053.
PANTHER	PTHR21371. AcH_isomrdctse. 1 hit.
Pfam	PF01450. IlvC. 1 hit. PF07991. IlvN. 1 hit. [Graphical view]
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMs	TIGR00465. IlvC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ILVC_NITMS

Accession

Primary (citable) accession number: A9A2E4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	January 15, 2008
Last modified:	January 25, 2012
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program