A9A231 (AROA_NITMS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable 3-phosphoshikimate 1-carboxyvinyltransferase
EC=2.5.1.19

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthase
Short name=EPSP synthase
Short name=EPSPS

Gene names

Name:	aroA
Ordered Locus Names:	Nmar_0548

Organism

Nitrosopumilus maritimus (strain SCM1)

Taxonomic identifier

436308 [NCBI]

Taxonomic lineage

Archaea › Thaumarchaeota › marine archaeal group 1 › Nitrosopumilales › Nitrosopumilaceae › Nitrosopumilus

Protein attributes

Sequence length	422 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210
Subunit structure	Monomer By similarity. HAMAP MF_00210
Subcellular location	Cytoplasm By similarity HAMAP MF_00210.
Sequence similarities	Belongs to the EPSP synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-phosphoshikimate 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 422	422	Probable 3-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210		PRO_1000099733

Sequences

	Sequence		Length	Mass (Da)
	A9A231 [UniParc]. Last modified January 15, 2008. Version 1. Checksum: 210BA605070D7586	FASTA	422	45,612
	10 20 30 40 50 60 MKCKVEKSKI SGQIVCPSNK SYTHRAIFLA SLAGNGSKVE NVLLSADTMA TVEACKKFGA 70 80 90 100 110 120 SIEIENSSII VKNPIKFDKI VPEINTENSG TTIRIASGIA SLFSEEITLT GDESLQKRPM 130 140 150 160 170 180 QPLLDALSSI GAQCQSTDGK PPIKITGKIS GGDVTIPGNF SSQFISALLI SAPLTEKGIN 190 200 210 220 230 240 LSIKDNLVSK PYLDATIATM RKFGVSVQTL IPYKRYNISP QVYNAATFTV PIDFSSLALL 250 260 270 280 290 300 LSAAVLNGDE TVIKGNIGNL PQGDEVFIDI LEQLGVTVNI GEDEIKIKSP EKLKGGRFDL 310 320 330 340 350 360 SNSPDLLPPL TILALNSENP IEIVNVKHAR LKETDRIAIT SRELVKLGIK VQENEDGLIL 370 380 390 400 410 420 ESTENLTGAE LNSENDHRLF MAFCIAGMYV GNCVVTDPES VQVSYPDFVE EMNRIGARIQ PE

References

[1]

"Complete sequence of Nitrosopumilus maritimus SCM1." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Stahl D., Richardson P. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SCM1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000866 Genomic DNA. Translation: ABX12444.1.
RefSeq	YP_001581882.1. NC_010085.1.
3D structure databases
ProteinModelPortal	A9A231.
ModBase	Search...
Protein-protein interaction databases
STRING	A9A231.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5773778.
GenomeReviews	Gene locus Nmar_0548 in contig CP000866_GR.
KEGG	nmr:Nmar_0548.
Phylogenomic databases
HOGENOM	HBG646626.
OMA	FADHRIA.
Family and domain databases
HAMAP	MF_00210. EPSP_synth. [Tree]
InterPro	IPR001986. Enolpyruvate_Tfrase_dom. IPR006264. EPSP_synthase. IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b. [Graphical view]
Gene3D	G3DSA:3.65.10.10. EPSP_synthase. 2 hits.
KO	K00800.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF000505. EPSPS. 1 hit.
SUPFAM	SSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMs	TIGR01356. AroA. 1 hit.
PROSITE	PS00104. EPSP_SYNTHASE_1. False negative. PS00885. EPSP_SYNTHASE_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROA_NITMS

Accession

Primary (citable) accession number: A9A231

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	January 15, 2008
Last modified:	January 25, 2012
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program