A9A1Z2 (A9A1Z2_NITMS) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Delta-aminolevulinic acid dehydratase RuleBase RU000515
EC=4.2.1.24 RuleBase RU000515

Gene names

Ordered Locus Names:

Nmar_0509

Organism

Nitrosopumilus maritimus (strain SCM1)

Taxonomic identifier

436308 [NCBI]

Taxonomic lineage

Archaea › Thaumarchaeota › marine archaeal group 1 › Nitrosopumilales › Nitrosopumilaceae › Nitrosopumilus

Protein attributes

Sequence length	326 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2 5-aminolevulinate = porphobilinogen + 2 H2O. RuleBase RU000515
Subunit structure	Homooctamer By similarity. PIRSR PIRSR001415-3 RuleBase RU000515
Sequence similarities	Belongs to the ALADH family. RuleBase RU004161

Ontologies

Keywords
Biological process	Porphyrin biosynthesis RuleBase RU000515
Ligand	Magnesium PIRSR PIRSR001415-5 Metal-binding PIRSR PIRSR001415-5 Zinc PIRSR PIRSR001415-3
Molecular function	Lyase RuleBase RU000515 EMBL ABX12405.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	porphyrin-containing compound biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW porphobilinogen synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	196	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Active site	249	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Metal binding	121	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	123	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	131	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	234	1	Magnesium By similarity PIRSR PIRSR001415-5
	Binding site	206	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	218	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	275	1	Substrate 2 By similarity PIRSR PIRSR001415-2
	Binding site	314	1	Substrate 2 By similarity PIRSR PIRSR001415-2

Sequences

	Sequence		Length	Mass (Da)
	A9A1Z2 [UniParc]. Last modified January 15, 2008. Version 1. Checksum: 2D44C271090F6E98	FASTA	326	35,863
	10 20 30 40 50 60 MSFPTRRLRR LRTSEKMREL VQETRLSPSD LICPIFVQED IKTRIKIESM PSIERLPLDD 70 80 90 100 110 120 VTDEVGTISD LGIPAIMLFG IPSNKDETGS SAFDDNGIVQ KAISQVRENF GDKIVIMADT 130 140 150 160 170 180 CLCQFTSTGH CGVISNNKVD NDASLELLAK TAVSQAKAGM DTSSPSAMMD GQVAAIRNAL 190 200 210 220 230 240 DDEGFSDVSI MSHAAKHRSN FYSPFRDAAA CAPEFGDRKT YQMPYTNARE AMMEVETDIN 250 260 270 280 290 300 EGVDIVMIKP ALSYLDLISE TRRRFNIPVA AYSVSGEYAL VKAASQLGYV NENEVTDEIL 310 320 SSIKRAGADM IVTYFAKSAA KFMQES

References

[1]

"Complete sequence of Nitrosopumilus maritimus SCM1." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Stahl D., Richardson P. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SCM1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000866 Genomic DNA. Translation: ABX12405.1.
RefSeq	YP_001581843.1. NC_010085.1.
3D structure databases
ProteinModelPortal	A9A1Z2.
SMR	A9A1Z2. Positions 6-324.
ModBase	Search...
Protein-protein interaction databases
STRING	A9A1Z2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5773055.
GenomeReviews	Gene locus Nmar_0509 in contig CP000866_GR.
KEGG	nmr:Nmar_0509.
Phylogenomic databases
HOGENOM	HBG285270.
OMA	NADSENA.
ProtClustDB	PRK09283.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR001731. Porphobilinogen_synth. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01698.
PANTHER	PTHR11458. AlaD_dehydratase. 1 hit.
Pfam	PF00490. ALAD. 1 hit. [Graphical view]
PIRSF	PIRSF001415. Porphbilin_synth. 1 hit.
PRINTS	PR00144. DALDHYDRTASE.
SMART	SM01004. ALAD. 1 hit. [Graphical view]
PROSITE	PS00169. D_ALA_DEHYDRATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A9A1Z2_NITMS

Accession

Primary (citable) accession number: A9A1Z2

Entry history

Integrated into UniProtKB/TrEMBL:	January 15, 2008
Last sequence update:	January 15, 2008
Last modified:	January 25, 2012
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)