Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable L-aspartate dehydrogenase

Gene

nadX

Organism
Nitrosopumilus maritimus (strain SCM1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.UniRule annotation

Miscellaneous

The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.UniRule annotation

Catalytic activityi

L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H.UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes iminoaspartate from L-aspartate (dehydrogenase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Probable L-aspartate dehydrogenase (nadX)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes iminoaspartate from L-aspartate (dehydrogenase route), the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei125NAD; via amide nitrogenUniRule annotation1
Binding sitei192NADUniRule annotation1
Active sitei222UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processPyridine nucleotide biosynthesis
LigandNAD, NADP

Enzyme and pathway databases

UniPathwayiUPA00253; UER00456

Names & Taxonomyi

Protein namesi
Recommended name:
Probable L-aspartate dehydrogenaseUniRule annotation (EC:1.4.1.21UniRule annotation)
Gene namesi
Name:nadXUniRule annotation
Ordered Locus Names:Nmar_1240
OrganismiNitrosopumilus maritimus (strain SCM1)
Taxonomic identifieri436308 [NCBI]
Taxonomic lineageiArchaeaThaumarchaeotaNitrosopumilalesNitrosopumilaceaeNitrosopumilus
Proteomesi
  • UP000000792 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001400881 – 272Probable L-aspartate dehydrogenaseAdd BLAST272

Proteomic databases

PRIDEiA9A1F7

Interactioni

Protein-protein interaction databases

STRINGi436308.Nmar_1240

Structurei

3D structure databases

ProteinModelPortaliA9A1F7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the L-aspartate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00254 Archaea
COG1712 LUCA
HOGENOMiHOG000206326
KOiK06989
OMAiMIMSVGA

Family and domain databases

HAMAPiMF_01265 NadX, 1 hit
InterProiView protein in InterPro
IPR005106 Asp/hSer_DH_NAD-bd
IPR002811 Asp_DH
IPR022487 Asp_DH_arc
IPR020626 Asp_DH_prok
IPR011182 L-Asp_DH
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF01958 DUF108, 1 hit
PF03447 NAD_binding_3, 1 hit
PIRSFiPIRSF005227 Asp_dh_NAD_syn, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR03855 NAD_NadX, 1 hit

Sequencei

Sequence statusi: Complete.

A9A1F7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRIALLGCG SMGTQIALAI DSENFPATLT HVYDESKDAS FSLTQKLKNK
60 70 80 90 100
PEIVENSHLL SSQPIDIVVE AASQNAVKDV ALSVIQNKKD LMIMSVGALL
110 120 130 140 150
DESIYDILSD ACNDFKKTIY LPSGAIAGLD GLKSVKDELE SISITTTKHP
160 170 180 190 200
RSLKGAKFFE TSDINLDEIT SSTVVYKGTA KEAVTLFPAN INVAALLSLT
210 220 230 240 250
GIGSEKTSVT IVADPNTDKN THHIEASGKF GTMTFTIENV PDSNNPKTSR
260 270
LAILSAIETL KKYCSDDIQI GT
Length:272
Mass (Da):29,185
Last modified:January 15, 2008 - v1
Checksum:i66E9C99CAF4E57D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000866 Genomic DNA Translation: ABX13136.1

Genome annotation databases

EnsemblBacteriaiABX13136; ABX13136; Nmar_1240
KEGGinmr:Nmar_1240

Similar proteinsi

Entry informationi

Entry nameiASPD_NITMS
AccessioniPrimary (citable) accession number: A9A1F7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: January 15, 2008
Last modified: May 23, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health