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A9A1F7

- ASPD_NITMS

UniProt

A9A1F7 - ASPD_NITMS

Protein

Probable L-aspartate dehydrogenase

Gene

nadX

Organism
Nitrosopumilus maritimus (strain SCM1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (15 Jan 2008)
      Previous versions | rss
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    • Comment

    Functioni

    Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.UniRule annotation

    Catalytic activityi

    L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei125 – 1251NAD; via amide nitrogenUniRule annotation
    Binding sitei192 – 1921NADUniRule annotation
    Active sitei222 – 2221UniRule annotation

    GO - Molecular functioni

    1. aspartate dehydrogenase activity Source: UniProtKB-EC
    2. NAD binding Source: UniProtKB-HAMAP
    3. NADP binding Source: UniProtKB-HAMAP
    4. oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD biosynthetic process Source: UniProtKB-HAMAP
    2. NADP catabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Keywords - Ligandi

    NAD, NADP

    Enzyme and pathway databases

    BioCyciNMAR436308:GI3J-1273-MONOMER.
    UniPathwayiUPA00253; UER00456.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable L-aspartate dehydrogenaseUniRule annotation (EC:1.4.1.21UniRule annotation)
    Gene namesi
    Name:nadXUniRule annotation
    Ordered Locus Names:Nmar_1240
    OrganismiNitrosopumilus maritimus (strain SCM1)
    Taxonomic identifieri436308 [NCBI]
    Taxonomic lineageiArchaeaThaumarchaeotaNitrosopumilalesNitrosopumilaceaeNitrosopumilus
    ProteomesiUP000000792: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 272272Probable L-aspartate dehydrogenasePRO_1000140088Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi436308.Nmar_1240.

    Structurei

    3D structure databases

    ProteinModelPortaliA9A1F7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the L-aspartate dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1712.
    HOGENOMiHOG000206326.
    KOiK06989.
    OMAiECAGHSA.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_01265. NadX.
    InterProiIPR005106. Asp/hSer_DH_NAD-bd.
    IPR002811. Asp_DH.
    IPR022487. Asp_DH_arc.
    IPR020626. Asp_DH_prok.
    IPR011182. L-Asp_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF01958. DUF108. 1 hit.
    PF03447. NAD_binding_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005227. Asp_dh_NAD_syn. 1 hit.
    TIGRFAMsiTIGR03855. NAD_NadX. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A9A1F7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKRIALLGCG SMGTQIALAI DSENFPATLT HVYDESKDAS FSLTQKLKNK    50
    PEIVENSHLL SSQPIDIVVE AASQNAVKDV ALSVIQNKKD LMIMSVGALL 100
    DESIYDILSD ACNDFKKTIY LPSGAIAGLD GLKSVKDELE SISITTTKHP 150
    RSLKGAKFFE TSDINLDEIT SSTVVYKGTA KEAVTLFPAN INVAALLSLT 200
    GIGSEKTSVT IVADPNTDKN THHIEASGKF GTMTFTIENV PDSNNPKTSR 250
    LAILSAIETL KKYCSDDIQI GT 272
    Length:272
    Mass (Da):29,185
    Last modified:January 15, 2008 - v1
    Checksum:i66E9C99CAF4E57D9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000866 Genomic DNA. Translation: ABX13136.1.
    RefSeqiYP_001582574.1. NC_010085.1.

    Genome annotation databases

    EnsemblBacteriaiABX13136; ABX13136; Nmar_1240.
    GeneIDi5773947.
    KEGGinmr:Nmar_1240.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000866 Genomic DNA. Translation: ABX13136.1 .
    RefSeqi YP_001582574.1. NC_010085.1.

    3D structure databases

    ProteinModelPortali A9A1F7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 436308.Nmar_1240.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABX13136 ; ABX13136 ; Nmar_1240 .
    GeneIDi 5773947.
    KEGGi nmr:Nmar_1240.

    Phylogenomic databases

    eggNOGi COG1712.
    HOGENOMi HOG000206326.
    KOi K06989.
    OMAi ECAGHSA.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00456 .
    BioCyci NMAR436308:GI3J-1273-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_01265. NadX.
    InterProi IPR005106. Asp/hSer_DH_NAD-bd.
    IPR002811. Asp_DH.
    IPR022487. Asp_DH_arc.
    IPR020626. Asp_DH_prok.
    IPR011182. L-Asp_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF01958. DUF108. 1 hit.
    PF03447. NAD_binding_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005227. Asp_dh_NAD_syn. 1 hit.
    TIGRFAMsi TIGR03855. NAD_NadX. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SCM1.

    Entry informationi

    Entry nameiASPD_NITMS
    AccessioniPrimary (citable) accession number: A9A1F7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3