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A8ZZU9

- GSA_DESOH

UniProt

A8ZZU9 - GSA_DESOH

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Protein
Glutamate-1-semialdehyde 2,1-aminomutase
Gene
hemL, Dole_1545
Organism
Desulfococcus oleovorans (strain DSM 6200 / Hxd3)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: InterPro

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Porphyrin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciDOLE96561:GHF3-1568-MONOMER.
UniPathwayiUPA00251; UER00317.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase (EC:5.4.3.8)
Short name:
GSA
Alternative name(s):
Glutamate-1-semialdehyde aminotransferase
Short name:
GSA-AT
Gene namesi
Name:hemL
Ordered Locus Names:Dole_1545
OrganismiDesulfococcus oleovorans (strain DSM 6200 / Hxd3)
Taxonomic identifieri96561 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobacteraceaeDesulfococcus
ProteomesiUP000008561: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 427427Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation
PRO_1000121877Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei267 – 2671N6-(pyridoxal phosphate)lysine By similarity

Proteomic databases

PRIDEiA8ZZU9.

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi96561.Dole_1545.

Structurei

3D structure databases

ProteinModelPortaliA8ZZU9.
SMRiA8ZZU9. Positions 1-423.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0001.
HOGENOMiHOG000020210.
KOiK01845.
OMAiHGHANAF.
OrthoDBiEOG6QVRHN.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00713. hemL. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8ZZU9-1 [UniParc]FASTAAdd to Basket

« Hide

MNQTRSKALF KEAAVLIPGG VNSPVRAGKA VGTTPLFIDR AQGAEIVDAD    50
GNVYIDYIGS WGPMILGHRH SAVMAAIETV LKRGLSFGAS TDLEARLARM 100
VADAVPSIEM VRMVNSGTEA TMSAIRLARG ITGRDGLVKF DGCYHGHADM 150
LLVDAGSGVA TQAIPGSPGV PADVVRHTIS LPYNNTAALK DCLDRKGEQI 200
ACVIVEPVAG NMGMVEPDPG FLSALRKETE KHGCLLIFDE VMSGFRVAYG 250
GAQARYRITP DITCLGKVIG GGMPVGAYGG SRQIMKHIAP EGNIYQAGTL 300
SGNPVAMAAG IATLSELKKP GVYEALEART RRLADGLARA AADAGVPVQA 350
HAVGAMLGLF FADRPVTDFA SAKTSDLSRF AAYYRAMLEK GIFLAPSQFE 400
AIFVSTAHTD DHIDRTVNAA KAVFADL 427
Length:427
Mass (Da):44,905
Last modified:January 15, 2008 - v1
Checksum:i95CD5061D62D465F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000859 Genomic DNA. Translation: ABW67349.1.
RefSeqiYP_001529426.1. NC_009943.1.

Genome annotation databases

EnsemblBacteriaiABW67349; ABW67349; Dole_1545.
GeneIDi5694382.
KEGGidol:Dole_1545.
PATRICi21693179. VBIDesOle35880_1597.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000859 Genomic DNA. Translation: ABW67349.1 .
RefSeqi YP_001529426.1. NC_009943.1.

3D structure databases

ProteinModelPortali A8ZZU9.
SMRi A8ZZU9. Positions 1-423.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 96561.Dole_1545.

Proteomic databases

PRIDEi A8ZZU9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABW67349 ; ABW67349 ; Dole_1545 .
GeneIDi 5694382.
KEGGi dol:Dole_1545.
PATRICi 21693179. VBIDesOle35880_1597.

Phylogenomic databases

eggNOGi COG0001.
HOGENOMi HOG000020210.
KOi K01845.
OMAi HGHANAF.
OrthoDBi EOG6QVRHN.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00317 .
BioCyci DOLE96561:GHF3-1568-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_00375. HemL_aminotrans_3.
InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR00713. hemL. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 6200 / Hxd3.

Entry informationi

Entry nameiGSA_DESOH
AccessioniPrimary (citable) accession number: A8ZZU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: January 15, 2008
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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