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A8ZZU9

- GSA_DESOH

UniProt

A8ZZU9 - GSA_DESOH

Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Desulfococcus oleovorans (strain DSM 6200 / Hxd3)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: InterPro
    3. transaminase activity Source: InterPro

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Porphyrin biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciDOLE96561:GHF3-1568-MONOMER.
    UniPathwayiUPA00251; UER00317.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
    Short name:
    GSAUniRule annotation
    Alternative name(s):
    Glutamate-1-semialdehyde aminotransferaseUniRule annotation
    Short name:
    GSA-ATUniRule annotation
    Gene namesi
    Name:hemLUniRule annotation
    Ordered Locus Names:Dole_1545
    OrganismiDesulfococcus oleovorans (strain DSM 6200 / Hxd3)
    Taxonomic identifieri96561 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobacteraceaeDesulfococcus
    ProteomesiUP000008561: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 427427Glutamate-1-semialdehyde 2,1-aminomutasePRO_1000121877Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei267 – 2671N6-(pyridoxal phosphate)lysineUniRule annotation

    Proteomic databases

    PRIDEiA8ZZU9.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi96561.Dole_1545.

    Structurei

    3D structure databases

    ProteinModelPortaliA8ZZU9.
    SMRiA8ZZU9. Positions 1-423.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0001.
    HOGENOMiHOG000020210.
    KOiK01845.
    OMAiHGHANAF.
    OrthoDBiEOG6QVRHN.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPiMF_00375. HemL_aminotrans_3.
    InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR11986. PTHR11986. 1 hit.
    PfamiPF00202. Aminotran_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR00713. hemL. 1 hit.
    PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8ZZU9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNQTRSKALF KEAAVLIPGG VNSPVRAGKA VGTTPLFIDR AQGAEIVDAD    50
    GNVYIDYIGS WGPMILGHRH SAVMAAIETV LKRGLSFGAS TDLEARLARM 100
    VADAVPSIEM VRMVNSGTEA TMSAIRLARG ITGRDGLVKF DGCYHGHADM 150
    LLVDAGSGVA TQAIPGSPGV PADVVRHTIS LPYNNTAALK DCLDRKGEQI 200
    ACVIVEPVAG NMGMVEPDPG FLSALRKETE KHGCLLIFDE VMSGFRVAYG 250
    GAQARYRITP DITCLGKVIG GGMPVGAYGG SRQIMKHIAP EGNIYQAGTL 300
    SGNPVAMAAG IATLSELKKP GVYEALEART RRLADGLARA AADAGVPVQA 350
    HAVGAMLGLF FADRPVTDFA SAKTSDLSRF AAYYRAMLEK GIFLAPSQFE 400
    AIFVSTAHTD DHIDRTVNAA KAVFADL 427
    Length:427
    Mass (Da):44,905
    Last modified:January 15, 2008 - v1
    Checksum:i95CD5061D62D465F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000859 Genomic DNA. Translation: ABW67349.1.
    RefSeqiYP_001529426.1. NC_009943.1.

    Genome annotation databases

    EnsemblBacteriaiABW67349; ABW67349; Dole_1545.
    GeneIDi5694382.
    KEGGidol:Dole_1545.
    PATRICi21693179. VBIDesOle35880_1597.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000859 Genomic DNA. Translation: ABW67349.1 .
    RefSeqi YP_001529426.1. NC_009943.1.

    3D structure databases

    ProteinModelPortali A8ZZU9.
    SMRi A8ZZU9. Positions 1-423.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 96561.Dole_1545.

    Proteomic databases

    PRIDEi A8ZZU9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABW67349 ; ABW67349 ; Dole_1545 .
    GeneIDi 5694382.
    KEGGi dol:Dole_1545.
    PATRICi 21693179. VBIDesOle35880_1597.

    Phylogenomic databases

    eggNOGi COG0001.
    HOGENOMi HOG000020210.
    KOi K01845.
    OMAi HGHANAF.
    OrthoDBi EOG6QVRHN.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00317 .
    BioCyci DOLE96561:GHF3-1568-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPi MF_00375. HemL_aminotrans_3.
    InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR11986. PTHR11986. 1 hit.
    Pfami PF00202. Aminotran_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR00713. hemL. 1 hit.
    PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 6200 / Hxd3.

    Entry informationi

    Entry nameiGSA_DESOH
    AccessioniPrimary (citable) accession number: A8ZZU9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3