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A8ZZJ0

- FTHS_DESOH

UniProt

A8ZZJ0 - FTHS_DESOH

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Protein

Formate--tetrahydrofolate ligase

Gene
fhs, Dole_3059
Organism
Desulfococcus oleovorans (strain DSM 6200 / Hxd3)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi73 – 808ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDOLE96561:GHF3-3105-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:Dole_3059
OrganismiDesulfococcus oleovorans (strain DSM 6200 / Hxd3)
Taxonomic identifieri96561 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobacteraceaeDesulfococcus
ProteomesiUP000008561: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 587587Formate--tetrahydrofolate ligaseUniRule annotationPRO_1000146681Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi96561.Dole_3059.

Structurei

3D structure databases

ProteinModelPortaliA8ZZJ0.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

A8ZZJ0-1 [UniParc]FASTAAdd to Basket

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MAYDATKMAD WQISEEAEKN MPMPEEWCEK LGLEKEEMLA MGRLSKLDFL    50
KIIKRLEAKP DGKYIEVTAI TPTPLGEGKS TTSLGLMEGL GARGKSVGGA 100
LRQPSGGPTM NVKGTAAGGG NSLLIPMTEF SLGLTGDIND IMNAHNLGMV 150
AMTARMQHER NYNDEQLQRL TGMRRLDIDP TRVEMGWIID FCAQALRNIV 200
IGLGGRTDGY TMQSKFGIAV GSELMAILAV ATDLADLKER INNITVAFDK 250
SGKPVTCRDL EVGNAMAAFM RNTINPTLMS TAEYQPCLVH AGPFANIAVG 300
QSSIIADRVG LKLWDYHVTE SGFAADIGFE KFWNVKCRFS GLKPHVSVLT 350
ATIRALKMHG GGPKVVAGKA LDDAYTKENL ALVEKGVENM VHMIGVIRKS 400
GINPVVCVNR FYTDTDAEVA IVKKAAEAAG ARCAESKHWE KGGEGALEFA 450
DAVIDACEEG NDFDFLYPLE MKLRDRVDKI AREVYGADGV DWSPEATAKA 500
EMLENDPKYA DFATMMVKTH LSLTHDPVKK GVPKGWRLPI RDVLIYSGAK 550
FLCPCAGTIS LMPGTGSNPA FRRIDVDPAT GKVSGLF 587
Length:587
Mass (Da):63,724
Last modified:January 15, 2008 - v1
Checksum:i3D1026866134F143
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000859 Genomic DNA. Translation: ABW68862.1.
RefSeqiYP_001530939.1. NC_009943.1.

Genome annotation databases

EnsemblBacteriaiABW68862; ABW68862; Dole_3059.
GeneIDi5695919.
KEGGidol:Dole_3059.
PATRICi21696343. VBIDesOle35880_3167.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000859 Genomic DNA. Translation: ABW68862.1 .
RefSeqi YP_001530939.1. NC_009943.1.

3D structure databases

ProteinModelPortali A8ZZJ0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 96561.Dole_3059.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABW68862 ; ABW68862 ; Dole_3059 .
GeneIDi 5695919.
KEGGi dol:Dole_3059.
PATRICi 21696343. VBIDesOle35880_3167.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci DOLE96561:GHF3-3105-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 6200 / Hxd3.

Entry informationi

Entry nameiFTHS_DESOH
AccessioniPrimary (citable) accession number: A8ZZJ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: January 15, 2008
Last modified: May 14, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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