Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A8ZZJ0 (FTHS_DESOH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:Dole_3059
OrganismDesulfococcus oleovorans (strain DSM 6200 / Hxd3) [Complete proteome] [HAMAP]
Taxonomic identifier96561 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobacteraceaeDesulfococcus

Protein attributes

Sequence length587 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 587587Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_1000146681

Regions

Nucleotide binding73 – 808ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A8ZZJ0 [UniParc].

Last modified January 15, 2008. Version 1.
Checksum: 3D1026866134F143

FASTA58763,724
        10         20         30         40         50         60 
MAYDATKMAD WQISEEAEKN MPMPEEWCEK LGLEKEEMLA MGRLSKLDFL KIIKRLEAKP 

        70         80         90        100        110        120 
DGKYIEVTAI TPTPLGEGKS TTSLGLMEGL GARGKSVGGA LRQPSGGPTM NVKGTAAGGG 

       130        140        150        160        170        180 
NSLLIPMTEF SLGLTGDIND IMNAHNLGMV AMTARMQHER NYNDEQLQRL TGMRRLDIDP 

       190        200        210        220        230        240 
TRVEMGWIID FCAQALRNIV IGLGGRTDGY TMQSKFGIAV GSELMAILAV ATDLADLKER 

       250        260        270        280        290        300 
INNITVAFDK SGKPVTCRDL EVGNAMAAFM RNTINPTLMS TAEYQPCLVH AGPFANIAVG 

       310        320        330        340        350        360 
QSSIIADRVG LKLWDYHVTE SGFAADIGFE KFWNVKCRFS GLKPHVSVLT ATIRALKMHG 

       370        380        390        400        410        420 
GGPKVVAGKA LDDAYTKENL ALVEKGVENM VHMIGVIRKS GINPVVCVNR FYTDTDAEVA 

       430        440        450        460        470        480 
IVKKAAEAAG ARCAESKHWE KGGEGALEFA DAVIDACEEG NDFDFLYPLE MKLRDRVDKI 

       490        500        510        520        530        540 
AREVYGADGV DWSPEATAKA EMLENDPKYA DFATMMVKTH LSLTHDPVKK GVPKGWRLPI 

       550        560        570        580 
RDVLIYSGAK FLCPCAGTIS LMPGTGSNPA FRRIDVDPAT GKVSGLF 

« Hide

References

[1]"Complete sequence of Desulfococcus oleovorans Hxd3."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Kim E., Wawrik B., Richardson P.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 6200 / Hxd3.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000859 Genomic DNA. Translation: ABW68862.1.
RefSeqYP_001530939.1. NC_009943.1.

3D structure databases

ProteinModelPortalA8ZZJ0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING96561.Dole_3059.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABW68862; ABW68862; Dole_3059.
GeneID5695919.
KEGGdol:Dole_3059.
PATRIC21696343. VBIDesOle35880_3167.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMALKHHGGV.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

BioCycDOLE96561:GHF3-3105-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
ProtoNetSearch...

Entry information

Entry nameFTHS_DESOH
AccessionPrimary (citable) accession number: A8ZZJ0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: January 15, 2008
Last modified: May 14, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways