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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Desulfococcus oleovorans (strain DSM 6200 / Hxd3)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathway: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi73 – 808ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDOLE96561:GHF3-3105-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:Dole_3059
OrganismiDesulfococcus oleovorans (strain DSM 6200 / Hxd3)
Taxonomic identifieri96561 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobacteraceaeDesulfococcus
ProteomesiUP000008561 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 587587Formate--tetrahydrofolate ligasePRO_1000146681Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi96561.Dole_3059.

Structurei

3D structure databases

ProteinModelPortaliA8ZZJ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiCMVKTHL.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

A8ZZJ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYDATKMAD WQISEEAEKN MPMPEEWCEK LGLEKEEMLA MGRLSKLDFL
60 70 80 90 100
KIIKRLEAKP DGKYIEVTAI TPTPLGEGKS TTSLGLMEGL GARGKSVGGA
110 120 130 140 150
LRQPSGGPTM NVKGTAAGGG NSLLIPMTEF SLGLTGDIND IMNAHNLGMV
160 170 180 190 200
AMTARMQHER NYNDEQLQRL TGMRRLDIDP TRVEMGWIID FCAQALRNIV
210 220 230 240 250
IGLGGRTDGY TMQSKFGIAV GSELMAILAV ATDLADLKER INNITVAFDK
260 270 280 290 300
SGKPVTCRDL EVGNAMAAFM RNTINPTLMS TAEYQPCLVH AGPFANIAVG
310 320 330 340 350
QSSIIADRVG LKLWDYHVTE SGFAADIGFE KFWNVKCRFS GLKPHVSVLT
360 370 380 390 400
ATIRALKMHG GGPKVVAGKA LDDAYTKENL ALVEKGVENM VHMIGVIRKS
410 420 430 440 450
GINPVVCVNR FYTDTDAEVA IVKKAAEAAG ARCAESKHWE KGGEGALEFA
460 470 480 490 500
DAVIDACEEG NDFDFLYPLE MKLRDRVDKI AREVYGADGV DWSPEATAKA
510 520 530 540 550
EMLENDPKYA DFATMMVKTH LSLTHDPVKK GVPKGWRLPI RDVLIYSGAK
560 570 580
FLCPCAGTIS LMPGTGSNPA FRRIDVDPAT GKVSGLF
Length:587
Mass (Da):63,724
Last modified:January 15, 2008 - v1
Checksum:i3D1026866134F143
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000859 Genomic DNA. Translation: ABW68862.1.
RefSeqiWP_012176473.1. NC_009943.1.
YP_001530939.1. NC_009943.1.

Genome annotation databases

EnsemblBacteriaiABW68862; ABW68862; Dole_3059.
KEGGidol:Dole_3059.
PATRICi21696343. VBIDesOle35880_3167.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000859 Genomic DNA. Translation: ABW68862.1.
RefSeqiWP_012176473.1. NC_009943.1.
YP_001530939.1. NC_009943.1.

3D structure databases

ProteinModelPortaliA8ZZJ0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi96561.Dole_3059.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABW68862; ABW68862; Dole_3059.
KEGGidol:Dole_3059.
PATRICi21696343. VBIDesOle35880_3167.

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiCMVKTHL.
OrthoDBiEOG6PCPSP.

Enzyme and pathway databases

UniPathwayiUPA00193.
BioCyciDOLE96561:GHF3-3105-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 6200 / Hxd3.

Entry informationi

Entry nameiFTHS_DESOH
AccessioniPrimary (citable) accession number: A8ZZJ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: January 15, 2008
Last modified: May 27, 2015
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.