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A8ZZJ0

- FTHS_DESOH

UniProt

A8ZZJ0 - FTHS_DESOH

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Desulfococcus oleovorans (strain DSM 6200 / Hxd3)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi73 – 808ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciDOLE96561:GHF3-3105-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:Dole_3059
    OrganismiDesulfococcus oleovorans (strain DSM 6200 / Hxd3)
    Taxonomic identifieri96561 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobacteraceaeDesulfococcus
    ProteomesiUP000008561: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 587587Formate--tetrahydrofolate ligasePRO_1000146681Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi96561.Dole_3059.

    Structurei

    3D structure databases

    ProteinModelPortaliA8ZZJ0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A8ZZJ0-1 [UniParc]FASTAAdd to Basket

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    MAYDATKMAD WQISEEAEKN MPMPEEWCEK LGLEKEEMLA MGRLSKLDFL    50
    KIIKRLEAKP DGKYIEVTAI TPTPLGEGKS TTSLGLMEGL GARGKSVGGA 100
    LRQPSGGPTM NVKGTAAGGG NSLLIPMTEF SLGLTGDIND IMNAHNLGMV 150
    AMTARMQHER NYNDEQLQRL TGMRRLDIDP TRVEMGWIID FCAQALRNIV 200
    IGLGGRTDGY TMQSKFGIAV GSELMAILAV ATDLADLKER INNITVAFDK 250
    SGKPVTCRDL EVGNAMAAFM RNTINPTLMS TAEYQPCLVH AGPFANIAVG 300
    QSSIIADRVG LKLWDYHVTE SGFAADIGFE KFWNVKCRFS GLKPHVSVLT 350
    ATIRALKMHG GGPKVVAGKA LDDAYTKENL ALVEKGVENM VHMIGVIRKS 400
    GINPVVCVNR FYTDTDAEVA IVKKAAEAAG ARCAESKHWE KGGEGALEFA 450
    DAVIDACEEG NDFDFLYPLE MKLRDRVDKI AREVYGADGV DWSPEATAKA 500
    EMLENDPKYA DFATMMVKTH LSLTHDPVKK GVPKGWRLPI RDVLIYSGAK 550
    FLCPCAGTIS LMPGTGSNPA FRRIDVDPAT GKVSGLF 587
    Length:587
    Mass (Da):63,724
    Last modified:January 15, 2008 - v1
    Checksum:i3D1026866134F143
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000859 Genomic DNA. Translation: ABW68862.1.
    RefSeqiYP_001530939.1. NC_009943.1.

    Genome annotation databases

    EnsemblBacteriaiABW68862; ABW68862; Dole_3059.
    GeneIDi5695919.
    KEGGidol:Dole_3059.
    PATRICi21696343. VBIDesOle35880_3167.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000859 Genomic DNA. Translation: ABW68862.1 .
    RefSeqi YP_001530939.1. NC_009943.1.

    3D structure databases

    ProteinModelPortali A8ZZJ0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 96561.Dole_3059.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABW68862 ; ABW68862 ; Dole_3059 .
    GeneIDi 5695919.
    KEGGi dol:Dole_3059.
    PATRICi 21696343. VBIDesOle35880_3167.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci DOLE96561:GHF3-3105-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 6200 / Hxd3.

    Entry informationi

    Entry nameiFTHS_DESOH
    AccessioniPrimary (citable) accession number: A8ZZJ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3