UniProtKB - A8ZZ59 (PNP_DESOH)
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Protein
Polyribonucleotide nucleotidyltransferase
Gene
pnp
Organism
Desulfococcus oleovorans (strain DSM 6200 / Hxd3)
Status
Functioni
Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation
Catalytic activityi
RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation
Cofactori
Mg2+UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 485 | MagnesiumUniRule annotation | 1 | |
Metal bindingi | 491 | MagnesiumUniRule annotation | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-EC
- RNA binding Source: UniProtKB-KW
GO - Biological processi
- mRNA catabolic process Source: InterPro
- RNA processing Source: InterPro
Keywordsi
Molecular function | Nucleotidyltransferase, RNA-binding, Transferase |
Ligand | Magnesium, Metal-binding |
Enzyme and pathway databases
BioCyci | DOLE96561:G1GAC-3141-MONOMER. |
Names & Taxonomyi
Protein namesi | Recommended name: Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)Alternative name(s): Polynucleotide phosphorylaseUniRule annotation Short name: PNPaseUniRule annotation |
Gene namesi | Name:pnpUniRule annotation Ordered Locus Names:Dole_3029 |
Organismi | Desulfococcus oleovorans (strain DSM 6200 / Hxd3) |
Taxonomic identifieri | 96561 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Deltaproteobacteria › Desulfobacterales › Desulfobacteraceae › Desulfococcus › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_1000147915 | 1 – 721 | Polyribonucleotide nucleotidyltransferaseAdd BLAST | 721 |
Structurei
3D structure databases
ProteinModelPortali | A8ZZ59. |
SMRi | A8ZZ59. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 552 – 611 | KHUniRule annotationAdd BLAST | 60 | |
Domaini | 621 – 689 | S1 motifUniRule annotationAdd BLAST | 69 |
Sequence similaritiesi
Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Phylogenomic databases
eggNOGi | ENOG4105C62. Bacteria. COG1185. LUCA. |
HOGENOMi | HOG000218326. |
KOi | K00962. |
OMAi | RYMHNYN. |
OrthoDBi | POG091H00M0. |
Family and domain databases
Gene3Di | 3.30.1370.10. 1 hit. 3.30.230.70. 2 hits. |
HAMAPi | MF_01595. PNPase. 1 hit. |
InterProi | View protein in InterPro IPR001247. ExoRNase_PH_dom1. IPR015847. ExoRNase_PH_dom2. IPR036345. ExoRNase_PH_dom2_sf. IPR004087. KH_dom. IPR004088. KH_dom_type_1. IPR036612. KH_dom_type_1_sf. IPR012340. NA-bd_OB-fold. IPR012162. PNPase. IPR027408. PNPase/RNase_PH_dom_sf. IPR015848. PNPase_PH_RNA-bd_bac/org-type. IPR036456. PNPase_PH_RNA-bd_sf. IPR020568. Ribosomal_S5_D2-typ_fold. IPR022967. S1_dom. IPR003029. S1_domain. |
PANTHERi | PTHR11252. PTHR11252. 1 hit. |
Pfami | View protein in Pfam PF00013. KH_1. 1 hit. PF03726. PNPase. 1 hit. PF01138. RNase_PH. 2 hits. PF03725. RNase_PH_C. 2 hits. PF00575. S1. 1 hit. |
PIRSFi | PIRSF005499. PNPase. 1 hit. |
SMARTi | View protein in SMART SM00322. KH. 1 hit. SM00316. S1. 1 hit. |
SUPFAMi | SSF46915. SSF46915. 1 hit. SSF50249. SSF50249. 1 hit. SSF54211. SSF54211. 2 hits. SSF54791. SSF54791. 1 hit. SSF55666. SSF55666. 2 hits. |
TIGRFAMsi | TIGR03591. polynuc_phos. 1 hit. |
PROSITEi | View protein in PROSITE PS50084. KH_TYPE_1. 1 hit. PS50126. S1. 1 hit. |
i Sequence
Sequence statusi: Complete.
A8ZZ59-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTEHVFEATV NGKPFTIKTG RLAKQAAGAA LVQYGETIVL VTVAAATEPK
60 70 80 90 100
EDADFLPLSV EYQEKIYSAG RIPGNYFRRE IGRPSEKETL TCRLTDRPIR
110 120 130 140 150
PLFPAGYTFE TQVITTVLSM DRENDPDVLS IVGASAALTI SDLPFDGPLA
160 170 180 190 200
AVRVGRLNGT LVANPTNTEL DDCDINIVVA GSRSGVVMVE GGSNVVSEAE
210 220 230 240 250
MLEAIFFGHN ALLPLIDIQD QMRNACGKPK RVIVPPEKDT ELETRIAELV
260 270 280 290 300
GDAVAQAVTE PEKDARKSAL SKVRENLFQG LGEAFADRKR EIKGLFSDLV
310 320 330 340 350
KKVCRDIVLN QGRRIDGRAF DEVRPISCEV GVLPRTHGSA LFTRGETQVL
360 370 380 390 400
GVMTLGSGHD EQRVETLFGD ETRPFMLHYN FPPFCVGEVK RVMGPSRRDI
410 420 430 440 450
GHGNLAHRGI SYVLPDKETF DYTIRLVSEV LESNGSSSMG TVCSCILALM
460 470 480 490 500
DGGVPIKAPV SGIAMGLVAD GDKVAVLSDI LGDEDHFGDM DFKVTGTEKG
510 520 530 540 550
ITALQMDIKI KSLSREILEK ALHQAKDGRI HILGKMLEAL SHYRDDISPY
560 570 580 590 600
APKIYIVKIH PDKIREIIGP GGKVIRELQA MSNTRIEVDD SGTVKIAAST
610 620 630 640 650
EEEARIAIKA VEDIGRVPEP GEIYEGEVVR ITDFGAFIQI KNGTDGLCHI
660 670 680 690 700
SELEHHHVKS VTDVVKMGDK VRVKVLEVSP EGKIRLSRKA LLPAPEKGEE
710 720
DEKSAPRSRR PGGNSDRRNN R
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000859 Genomic DNA. Translation: ABW68832.1. |
RefSeqi | WP_012176443.1. NC_009943.1. |
Genome annotation databases
EnsemblBacteriai | ABW68832; ABW68832; Dole_3029. |
KEGGi | dol:Dole_3029. |
Similar proteinsi
Entry informationi
Entry namei | PNP_DESOH | |
Accessioni | A8ZZ59Primary (citable) accession number: A8ZZ59 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 14, 2009 |
Last sequence update: | January 15, 2008 | |
Last modified: | February 28, 2018 | |
This is version 65 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |