pnp

Functionⁱ

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityⁱ

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactorⁱ

Mg²⁺UniRule annotation

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Metal bindingⁱ	485	MagnesiumUniRule annotation		1
Metal bindingⁱ	491	MagnesiumUniRule annotation		1

GO - Molecular functionⁱ

metal ion binding Source: UniProtKB-KW
polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-EC
RNA binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

mRNA catabolic process Source: InterPro
RNA processing Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Nucleotidyltransferase, RNA-binding, Transferase
Ligand	Magnesium, Metal-binding

Enzyme and pathway databases

BioCycⁱ	DOLE96561:G1GAC-3141-MONOMER.

BioCycⁱ

DOLE96561:G1GAC-3141-MONOMER.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation) Alternative name(s): Polynucleotide phosphorylaseUniRule annotation Short name: PNPaseUniRule annotation
Gene namesⁱ	Name:pnpUniRule annotation Ordered Locus Names:Dole_3029
Organismⁱ	Desulfococcus oleovorans (strain DSM 6200 / Hxd3)
Taxonomic identifierⁱ	96561 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Deltaproteobacteria › Desulfobacterales › Desulfobacteraceae › Desulfococcus › Desulfococcus oleovorans
Proteomesⁱ	UP000008561 Componentⁱ: Chromosome

Subcellular locationⁱ

Cytoplasm
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_01595

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_1000147915	1 – 721	Polyribonucleotide nucleotidyltransferaseAdd BLAST		721

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	96561.Dole_3029.

STRINGⁱ

96561.Dole_3029.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	A8ZZ59.
SMRⁱ	A8ZZ59.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	552 – 611	KHUniRule annotationAdd BLAST		60
Domainⁱ	621 – 689	S1 motifUniRule annotationAdd BLAST		69

Sequence similaritiesⁱ

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	ENOG4105C62. Bacteria. COG1185. LUCA.
HOGENOMⁱ	HOG000218326.
KEGG Orthology (KO) More...KOⁱ	K00962.
OMAⁱ	RYMHNYN.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H00M0.

Family and domain databases

Gene3Dⁱ	3.30.1370.10. 1 hit. 3.30.230.70. 2 hits.
HAMAPⁱ	MF_01595. PNPase. 1 hit.
InterProⁱ	View protein in InterPro IPR001247. ExoRNase_PH_dom1. IPR015847. ExoRNase_PH_dom2. IPR036345. ExoRNase_PH_dom2_sf. IPR004087. KH_dom. IPR004088. KH_dom_type_1. IPR036612. KH_dom_type_1_sf. IPR012340. NA-bd_OB-fold. IPR012162. PNPase. IPR027408. PNPase/RNase_PH_dom_sf. IPR015848. PNPase_PH_RNA-bd_bac/org-type. IPR036456. PNPase_PH_RNA-bd_sf. IPR020568. Ribosomal_S5_D2-typ_fold. IPR022967. S1_dom. IPR003029. S1_domain.
PANTHERⁱ	PTHR11252. PTHR11252. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00013. KH_1. 1 hit. PF03726. PNPase. 1 hit. PF01138. RNase_PH. 2 hits. PF03725. RNase_PH_C. 2 hits. PF00575. S1. 1 hit.
PIRSFⁱ	PIRSF005499. PNPase. 1 hit.
SMARTⁱ	View protein in SMART SM00322. KH. 1 hit. SM00316. S1. 1 hit.
SUPFAMⁱ	SSF46915. SSF46915. 1 hit. SSF50249. SSF50249. 1 hit. SSF54211. SSF54211. 2 hits. SSF54791. SSF54791. 1 hit. SSF55666. SSF55666. 2 hits.
TIGRFAMsⁱ	TIGR03591. polynuc_phos. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50084. KH_TYPE_1. 1 hit. PS50126. S1. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

A8ZZ59-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTEHVFEATV NGKPFTIKTG RLAKQAAGAA LVQYGETIVL VTVAAATEPK 
        60         70         80         90        100
EDADFLPLSV EYQEKIYSAG RIPGNYFRRE IGRPSEKETL TCRLTDRPIR 
       110        120        130        140        150
PLFPAGYTFE TQVITTVLSM DRENDPDVLS IVGASAALTI SDLPFDGPLA 
       160        170        180        190        200
AVRVGRLNGT LVANPTNTEL DDCDINIVVA GSRSGVVMVE GGSNVVSEAE 
       210        220        230        240        250
MLEAIFFGHN ALLPLIDIQD QMRNACGKPK RVIVPPEKDT ELETRIAELV 
       260        270        280        290        300
GDAVAQAVTE PEKDARKSAL SKVRENLFQG LGEAFADRKR EIKGLFSDLV 
       310        320        330        340        350
KKVCRDIVLN QGRRIDGRAF DEVRPISCEV GVLPRTHGSA LFTRGETQVL 
       360        370        380        390        400
GVMTLGSGHD EQRVETLFGD ETRPFMLHYN FPPFCVGEVK RVMGPSRRDI 
       410        420        430        440        450
GHGNLAHRGI SYVLPDKETF DYTIRLVSEV LESNGSSSMG TVCSCILALM 
       460        470        480        490        500
DGGVPIKAPV SGIAMGLVAD GDKVAVLSDI LGDEDHFGDM DFKVTGTEKG 
       510        520        530        540        550
ITALQMDIKI KSLSREILEK ALHQAKDGRI HILGKMLEAL SHYRDDISPY 
       560        570        580        590        600
APKIYIVKIH PDKIREIIGP GGKVIRELQA MSNTRIEVDD SGTVKIAAST 
       610        620        630        640        650
EEEARIAIKA VEDIGRVPEP GEIYEGEVVR ITDFGAFIQI KNGTDGLCHI 
       660        670        680        690        700
SELEHHHVKS VTDVVKMGDK VRVKVLEVSP EGKIRLSRKA LLPAPEKGEE 
       710        720 
DEKSAPRSRR PGGNSDRRNN R

Length:721

Mass (Da):78,781

Last modified:January 15, 2008 - v1

Checksum:ⁱ4287C377C4AA9D4F

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000859 Genomic DNA. Translation: ABW68832.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_012176443.1. NC_009943.1.

Genome annotation databases

EnsemblBacteriaⁱ	ABW68832; ABW68832; Dole_3029.
KEGGⁱ	dol:Dole_3029.

Similar proteinsⁱ

50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
A8ZZ59	Q12QG9 V1DDF3 A0A073KS19 H1ADJ8 A0A1S2TZ74 A3D7K1 A9KZW6 G0B0K6 UPI0004692199 A0A165JYZ0 +273	Shewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013) Shewanella decolorationis S12 Shewanella xiamenensis Shewanella livingstonensis Shewanella algae Shewanella baltica (strain OS155 / ATCC BAA-1091) Shewanella baltica (strain OS195) Shewanella baltica BA175 Shewanella Shewanella baltica And more	698	UniRef50_Q12QG9	Cluster: Polyribonucleotide nucleotidyltransferase	284

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000859 Genomic DNA. Translation: ABW68832.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_012176443.1. NC_009943.1.

3D structure databases

ProteinModelPortalⁱ	A8ZZ59.
SMRⁱ	A8ZZ59.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	96561.Dole_3029.

STRINGⁱ

96561.Dole_3029.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	ABW68832; ABW68832; Dole_3029.
KEGGⁱ	dol:Dole_3029.

Phylogenomic databases

eggNOGⁱ	ENOG4105C62. Bacteria. COG1185. LUCA.
HOGENOMⁱ	HOG000218326.
KEGG Orthology (KO) More...KOⁱ	K00962.
OMAⁱ	RYMHNYN.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H00M0.

Enzyme and pathway databases

BioCycⁱ	DOLE96561:G1GAC-3141-MONOMER.

BioCycⁱ

DOLE96561:G1GAC-3141-MONOMER.

Family and domain databases

Gene3Dⁱ	3.30.1370.10. 1 hit. 3.30.230.70. 2 hits.
HAMAPⁱ	MF_01595. PNPase. 1 hit.
InterProⁱ	View protein in InterPro IPR001247. ExoRNase_PH_dom1. IPR015847. ExoRNase_PH_dom2. IPR036345. ExoRNase_PH_dom2_sf. IPR004087. KH_dom. IPR004088. KH_dom_type_1. IPR036612. KH_dom_type_1_sf. IPR012340. NA-bd_OB-fold. IPR012162. PNPase. IPR027408. PNPase/RNase_PH_dom_sf. IPR015848. PNPase_PH_RNA-bd_bac/org-type. IPR036456. PNPase_PH_RNA-bd_sf. IPR020568. Ribosomal_S5_D2-typ_fold. IPR022967. S1_dom. IPR003029. S1_domain.
PANTHERⁱ	PTHR11252. PTHR11252. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00013. KH_1. 1 hit. PF03726. PNPase. 1 hit. PF01138. RNase_PH. 2 hits. PF03725. RNase_PH_C. 2 hits. PF00575. S1. 1 hit.
PIRSFⁱ	PIRSF005499. PNPase. 1 hit.
SMARTⁱ	View protein in SMART SM00322. KH. 1 hit. SM00316. S1. 1 hit.
SUPFAMⁱ	SSF46915. SSF46915. 1 hit. SSF50249. SSF50249. 1 hit. SSF54211. SSF54211. 2 hits. SSF54791. SSF54791. 1 hit. SSF55666. SSF55666. 2 hits.
TIGRFAMsⁱ	TIGR03591. polynuc_phos. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50084. KH_TYPE_1. 1 hit. PS50126. S1. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PNP_DESOH
Accessionⁱ	A8ZZ59Primary (citable) accession number: A8ZZ59
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
	Last sequence update:	January 15, 2008
	Last modified:	February 28, 2018
	This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A8ZZ59 (PNP_DESOH)

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Polyribonucleotide nucleotidyltransferase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ