A8ZY13 (A8ZY13_DESOH) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Lipid-A-disaccharide synthase HAMAP MF_00392
EC=2.4.1.182 HAMAP MF_00392

Gene names

Name:	lpxB HAMAP MF_00392
Ordered Locus Names:	Dole_2837

Organism

Desulfococcus oleovorans (strain DSM 6200 / Hxd3) [Complete proteome] [HAMAP]

Taxonomic identifier

96561 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Desulfobacterales › Desulfobacteraceae › Desulfococcus

Protein attributes

Sequence length	389 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP MF_00392 SAAS SAAS003835
Catalytic activity	UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP MF_00392 SAAS SAAS003835
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP MF_00392 SAAS SAAS003835
Sequence similarities	Belongs to the lpxB family. HAMAP MF_00392

Ontologies

Keywords
Biological process	Lipid A biosynthesis HAMAP MF_00392 SAAS SAAS003835 Lipid synthesis
Molecular function	Glycosyltransferase HAMAP MF_00392 SAAS SAAS003835 EMBL ABW68640.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	lipid-A-disaccharide synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A8ZY13 [UniParc]. Last modified January 15, 2008. Version 1. Checksum: 45D78EF1EC135C43	FASTA	389	42,402
	10 20 30 40 50 60 MDKHALPNRV PVGRCVMIIA GEASGDLHGA NLIRNMREQI KDPLFFCGIG GAAMRRAGAK 70 80 90 100 110 120 ILVEAERLSV VGITEVIARM PDILSGMKTA KRMLASRIPD LLVLIDFPDF NLRMAATAKK 130 140 150 160 170 180 HGIPVFYYIS PQVWAWRKGR VRTIRKRVDH TAVILPFEAD FFKAHDVPVT FVGHPLLDAG 190 200 210 220 230 240 YGPAPLYERT EGRTVVGLLP GSRGSEVARH LPVMMEAGAR ISRRHPHVTF MVSCAHSIPV 250 260 270 280 290 300 ESMASITEKY IGTVPFTIVP GDVTQVLKRS TCVVAVSGTV SLETALYGVP MVVIYKVSFL 310 320 330 340 350 360 SYWLAKALIR LEHISLVNLI AGKAVVPELI QKDASAEHIA ARIMSMISDP QELETVRKEL 370 380 AEVRKRLGGP GASARAAGIA ARLLNEGVT

References

[1]

"Complete sequence of Desulfococcus oleovorans Hxd3." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Kim E., Wawrik B., Richardson P. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 6200 / Hxd3.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000859 Genomic DNA. Translation: ABW68640.1.
RefSeq	YP_001530717.1. NC_009943.1.
3D structure databases
ProteinModelPortal	A8ZY13.
ModBase	Search...
Protein-protein interaction databases
STRING	A8ZY13.
Protein family/group databases
CAZy	GT19. Glycosyltransferase Family 19.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5695695.
GenomeReviews	Gene locus Dole_2837 in contig CP000859_GR.
KEGG	dol:Dole_2837.
PATRIC	21695863. VBIDesOle35880_2919.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG584837.
OMA	AEFAFIC.
ProtClustDB	CLSK2402333.
Family and domain databases
HAMAP	MF_00392. LpxB. [Tree]
InterPro	IPR003835. Glyco_trans_19. [Graphical view]
KO	K00748.
Pfam	PF02684. LpxB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00215. LpxB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A8ZY13_DESOH

Accession

Primary (citable) accession number: A8ZY13

Entry history

Integrated into UniProtKB/TrEMBL:	January 15, 2008
Last sequence update:	January 15, 2008
Last modified:	December 14, 2011
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)