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Protein

D-alanine--D-alanine ligase

Gene

Dole_2749

Organism
Desulfococcus oleovorans (strain DSM 6200 / Hxd3)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Cell wall formation.SAAS annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.SAAS annotation

Cofactori

Mg2+SAAS annotation, Mn2+SAAS annotationNote: Binds 2 magnesium or manganese ions per subunit.SAAS annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. D-alanine-D-alanine ligase activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. peptidoglycan biosynthetic process Source: UniProtKB-UniPathway
  3. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseSAAS annotationImported

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradationSAAS annotation, Peptidoglycan synthesisSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, MagnesiumSAAS annotation, ManganeseSAAS annotation, Metal-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciDOLE96561:GHF3-2791-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseSAAS annotation (EC:6.3.2.4SAAS annotation)
Gene namesi
Ordered Locus Names:Dole_2749Imported
OrganismiDesulfococcus oleovorans (strain DSM 6200 / Hxd3)Imported
Taxonomic identifieri96561 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobacteraceaeDesulfococcus
ProteomesiUP000008561: Chromosome

Subcellular locationi

Cytoplasm SAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi96561.Dole_2749.

Structurei

3D structure databases

ProteinModelPortaliA8ZXS5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains ATP-grasp domain.SAAS annotation

Phylogenomic databases

eggNOGiCOG1181.
KOiK01921.
OMAiPRSTKTY.
OrthoDBiEOG66MQKK.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 1 hit.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8ZXS5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLAFLYNVR HQYPDPDRPE TQVEADFDDP ETIAAMTAHL RECGFDVIPI
60 70 80 90 100
EADPDAYIKL YENRDSIDLV FNYSIGIYGQ ARYAQVPAML EMLRLPYTGS
110 120 130 140 150
GPLTQALILD KARMQQVLSA CNVPVLCSQV FETGDEPLQS GLAFPLIVKP
160 170 180 190 200
VAQGSSAGIT SDSVVRDEAA LYRQVGRVMA TFGEPALVQP FLDGREFSIP
210 220 230 240 250
MMGNPPEIFP IIEPDFSRLP EGYARIDSLE VKWIFEEQAE SHHLICPAPV
260 270 280 290 300
APGLQERLEQ TVRAAWKALG ICDWCRIDLR CDMAGTPYVI DVNSPPGMIP
310 320 330
PEGSMTSYFP MSARAAGIDY QGLLKRLIET AMDRLSAR
Length:338
Mass (Da):37,520
Last modified:January 15, 2008 - v1
Checksum:i66429646D86096C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000859 Genomic DNA. Translation: ABW68552.1.
RefSeqiYP_001530629.1. NC_009943.1.

Genome annotation databases

EnsemblBacteriaiABW68552; ABW68552; Dole_2749.
GeneIDi5695605.
KEGGidol:Dole_2749.
PATRICi21695669. VBIDesOle35880_2824.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000859 Genomic DNA. Translation: ABW68552.1.
RefSeqiYP_001530629.1. NC_009943.1.

3D structure databases

ProteinModelPortaliA8ZXS5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi96561.Dole_2749.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABW68552; ABW68552; Dole_2749.
GeneIDi5695605.
KEGGidol:Dole_2749.
PATRICi21695669. VBIDesOle35880_2824.

Phylogenomic databases

eggNOGiCOG1181.
KOiK01921.
OMAiPRSTKTY.
OrthoDBiEOG66MQKK.

Enzyme and pathway databases

UniPathwayiUPA00219.
BioCyciDOLE96561:GHF3-2791-MONOMER.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 1 hit.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 6200 / Hxd3Imported.

Entry informationi

Entry nameiA8ZXS5_DESOH
AccessioniPrimary (citable) accession number: A8ZXS5
Entry historyi
Integrated into UniProtKB/TrEMBL: January 15, 2008
Last sequence update: January 15, 2008
Last modified: February 4, 2015
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.