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A8ZWQ4

- NADK_DESOH

UniProt

A8ZWQ4 - NADK_DESOH

Protein

NAD kinase

Gene

nadK

Organism
Desulfococcus oleovorans (strain DSM 6200 / Hxd3)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei57 – 571Proton acceptorUniRule annotation
    Binding sitei142 – 1421NADUniRule annotation
    Binding sitei159 – 1591NADUniRule annotation
    Binding sitei161 – 1611NADUniRule annotation
    Binding sitei231 – 2311NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi57 – 582NADUniRule annotation
    Nucleotide bindingi131 – 1322NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciDOLE96561:GHF3-2619-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinaseUniRule annotation
    Gene namesi
    Name:nadKUniRule annotation
    Ordered Locus Names:Dole_2582
    OrganismiDesulfococcus oleovorans (strain DSM 6200 / Hxd3)
    Taxonomic identifieri96561 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobacteraceaeDesulfococcus
    ProteomesiUP000008561: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 278278NAD kinasePRO_1000133568Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi96561.Dole_2582.

    Structurei

    3D structure databases

    ProteinModelPortaliA8ZWQ4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    HOGENOMiHOG000227222.
    KOiK00858.
    OMAiTHEMLYH.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A8ZWQ4-1 [UniParc]FASTAAdd to Basket

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    MKTIGLVVKT DPEAARNADE LEKWLAGRGV GVVRTGSVSD DRKAPVDLGC    50
    VFVLGGDGTF LSAARWIGDA PIPLVGIKFG GVGFLSETVE DDLFSAAEKI 100
    LKGEFTIAKR MRLRVTIYEN GQEQARRTVL NDVVINKGAL ARLAHIHTFV 150
    DGYDLTTYHG DGLIVSTPTG STAYSLAAGG PVIHPAVPGI ILTPICPFTL 200
    TNRPLVVPDS VRIELRLAQS PSDIMVTLDG QEGFEMTEGH RLMIEKAAHP 250
    VHMIILPGQR YFDVLKTKLK WGGGPAGY 278
    Length:278
    Mass (Da):29,899
    Last modified:January 15, 2008 - v1
    Checksum:i3F4F45BF11CA8820
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000859 Genomic DNA. Translation: ABW68385.1.
    RefSeqiYP_001530462.1. NC_009943.1.

    Genome annotation databases

    EnsemblBacteriaiABW68385; ABW68385; Dole_2582.
    GeneIDi5695433.
    KEGGidol:Dole_2582.
    PATRICi21695333. VBIDesOle35880_2661.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000859 Genomic DNA. Translation: ABW68385.1 .
    RefSeqi YP_001530462.1. NC_009943.1.

    3D structure databases

    ProteinModelPortali A8ZWQ4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 96561.Dole_2582.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABW68385 ; ABW68385 ; Dole_2582 .
    GeneIDi 5695433.
    KEGGi dol:Dole_2582.
    PATRICi 21695333. VBIDesOle35880_2661.

    Phylogenomic databases

    eggNOGi COG0061.
    HOGENOMi HOG000227222.
    KOi K00858.
    OMAi THEMLYH.
    OrthoDBi EOG6PZXDR.

    Enzyme and pathway databases

    BioCyci DOLE96561:GHF3-2619-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 6200 / Hxd3.

    Entry informationi

    Entry nameiNADK_DESOH
    AccessioniPrimary (citable) accession number: A8ZWQ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3