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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Desulfococcus oleovorans (strain DSM 6200 / Hxd3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (gpmI)
  4. Enolase (eno)
  5. Pyruvate kinase (Dole_2125)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei35SubstrateUniRule annotation1
Binding sitei117SubstrateUniRule annotation1
Binding sitei150SubstrateUniRule annotation1
Binding sitei201ATPUniRule annotation1
Binding sitei323ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi349 – 352ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDOLE96561:G1GAC-707-MONOMER
UniPathwayiUPA00109; UER00185

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
Gene namesi
Name:pgkUniRule annotation
Ordered Locus Names:Dole_0677
OrganismiDesulfococcus oleovorans (strain DSM 6200 / Hxd3)
Taxonomic identifieri96561 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobacteraceaeDesulfococcus
Proteomesi
  • UP000008561 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000963381 – 396Phosphoglycerate kinaseAdd BLAST396

Proteomic databases

PRIDEiA8ZUS4

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi96561.Dole_0677

Structurei

3D structure databases

SMRiA8ZUS4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni19 – 21Substrate bindingUniRule annotation3
Regioni58 – 61Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105BZA Bacteria
COG0126 LUCA
HOGENOMiHOG000227107
KOiK00927
OMAiDMIFDIG
OrthoDBiPOG091H00YN

Family and domain databases

CDDicd00318 Phosphoglycerate_kinase, 1 hit
Gene3Di3.40.50.1260, 3 hits
HAMAPiMF_00145 Phosphoglyc_kinase, 1 hit
InterProiView protein in InterPro
IPR001576 Phosphoglycerate_kinase
IPR015911 Phosphoglycerate_kinase_CS
IPR015824 Phosphoglycerate_kinase_N
IPR036043 Phosphoglycerate_kinase_sf
PANTHERiPTHR11406 PTHR11406, 1 hit
PfamiView protein in Pfam
PF00162 PGK, 1 hit
PIRSFiPIRSF000724 Pgk, 1 hit
PRINTSiPR00477 PHGLYCKINASE
SUPFAMiSSF53748 SSF53748, 1 hit
PROSITEiView protein in PROSITE
PS00111 PGLYCERATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

A8ZUS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSLKTIDVA GKRVLVRVDF NVPLDDQQQI TDDTRIQSAV PTIEYLVGAG
60 70 80 90 100
AKVIVCSHLG RPKGKPDPVF SLAPTARRLG ELLDRPVEMA NTCVGPDVVS
110 120 130 140 150
RIARMAPGDV LMLENLRFHP GEANDDDAFA RALAALCDVY VDDAFAVSHR
160 170 180 190 200
ANASVDAVTK YAPVCAPGFL MEKELGAFGK ALENPARPFV AIVGGAKVSS
210 220 230 240 250
KLPALQHLLQ EVDRLIIGGA MANTFLAAKG VNVGKSKIEQ ELIGEARSVI
260 270 280 290 300
RQAAEKKVEL FLPVDVIVAE KIDPDADRQA VSVDRIPADA MALDIGPETS
310 320 330 340 350
RLFGDALKDA KTIVWNGPMG IFEMEAFAAG TKAVAAAVAD SKAFTVVGGG
360 370 380 390
DTVSAVHEAG VADRISYIST GGGAFLELME GKTLPGVAAL ERNQPA
Length:396
Mass (Da):41,760
Last modified:January 15, 2008 - v1
Checksum:i2A80BE051E8BFDB2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000859 Genomic DNA Translation: ABW66487.1
RefSeqiWP_012174106.1, NC_009943.1

Genome annotation databases

EnsemblBacteriaiABW66487; ABW66487; Dole_0677
KEGGidol:Dole_0677

Similar proteinsi

Entry informationi

Entry nameiPGK_DESOH
AccessioniPrimary (citable) accession number: A8ZUS4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: January 15, 2008
Last modified: May 23, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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